ID   TR107_RAT               Reviewed;         308 AA.
AC   Q9JKT9;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Taste receptor type 2 member 107;
DE            Short=T2R107;
DE   AltName: Full=Taste receptor type 2 member 4;
DE            Short=T2R4;
GN   Name=Tas2r107 {ECO:0000250|UniProtKB:Q7M725};
GN   Synonyms=Tas2r10 {ECO:0000312|RGD:620736}, Tas2r4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:AAF43915.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10761934; DOI=10.1016/s0092-8674(00)80705-9;
RA   Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P.,
RA   Zuker C.S.;
RT   "A novel family of mammalian taste receptors.";
RL   Cell 100:693-702(2000).
CC   -!- FUNCTION: Putative taste receptor which may play a role in the
CC       perception of bitterness. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Several bitter taste receptors with distinct ligand
CC       specificities are expressed in a single taste receptor cell.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF227142; AAF43915.1; -; mRNA.
DR   RefSeq; NP_076485.1; NM_023995.1.
DR   AlphaFoldDB; Q9JKT9; -.
DR   SMR; Q9JKT9; -.
DR   STRING; 10116.ENSRNOP00000007453; -.
DR   GlyGen; Q9JKT9; 4 sites.
DR   PaxDb; Q9JKT9; -.
DR   GeneID; 78981; -.
DR   KEGG; rno:78981; -.
DR   UCSC; RGD:620736; rat.
DR   CTD; 387342; -.
DR   RGD; 620736; Tas2r107.
DR   eggNOG; ENOG502T3AX; Eukaryota.
DR   InParanoid; Q9JKT9; -.
DR   OrthoDB; 1010573at2759; -.
DR   PhylomeDB; Q9JKT9; -.
DR   PRO; PR:Q9JKT9; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008527; F:taste receptor activity; TAS:UniProtKB.
DR   GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR   InterPro; IPR007960; TAS2R.
DR   Pfam; PF05296; TAS2R; 1.
PE   2: Evidence at transcript level;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..308
FT                   /note="Taste receptor type 2 member 107"
FT                   /id="PRO_0000248253"
FT   TOPO_DOM        1..7
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        8..28
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        29..43
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        65..94
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        116..127
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..148
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        149..180
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        202..232
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..253
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        254..258
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        259..279
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        280..308
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        80
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        153
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        161
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        175
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   308 AA;  35052 MW;  00BC4193204EF043 CRC64;
     MLSAAEGILL CVVTSEAVLG VLGDTFIALA NCMEYAKNKK LSKIGFILIG LAISRIGVVW
     IIILQGYMQV FFPHILTFGN ITEYITYIWV FLNHLSVWFA TNLNILYFLK IANFSNSVFL
     WLKSRVRVVF IFLSGCLLTS WLLCFPQFSK MLNNSKMYWG NTSWLQQQKN VFLINQSLTN
     LGIFFFIIVS LITCFLLIVF LWRHIRQMHS DGSGLRDLNT EAHVKAMRVL ISFAVLFILH
     FVGLSIQVLC FFLPQNNLLF ITGLIATCLY PCGHSIILIL GNKQLKQASL KALQHLTCCE
     TKRNLSVT