TR109_MOUSE
ID TR109_MOUSE Reviewed; 316 AA.
AC Q7M707;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Taste receptor type 2 member 109;
DE Short=T2R109;
DE Short=mT2R62;
GN Name=Tas2r109 {ECO:0000312|MGI:MGI:2681214};
GN Synonyms=T2r62 {ECO:0000303|PubMed:12679530};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000305, ECO:0000312|EMBL:DAA01229.1}
RP IDENTIFICATION.
RX PubMed=12679530; DOI=10.1093/molbev/msg083;
RA Shi P., Zhang J., Yang H., Zhang Y.-P.;
RT "Adaptive diversification of bitter taste receptor genes in mammalian
RT evolution.";
RL Mol. Biol. Evol. 20:805-814(2003).
CC -!- FUNCTION: Putative taste receptor which may play a role in the
CC perception of bitterness. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000255}.
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DR EMBL; AC151055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK001090; DAA01229.1; -; Genomic_DNA.
DR CCDS; CCDS20631.1; -.
DR RefSeq; NP_996900.1; NM_207017.1.
DR AlphaFoldDB; Q7M707; -.
DR SMR; Q7M707; -.
DR STRING; 10090.ENSMUSP00000069300; -.
DR GlyGen; Q7M707; 1 site.
DR PaxDb; Q7M707; -.
DR PRIDE; Q7M707; -.
DR DNASU; 387343; -.
DR Ensembl; ENSMUST00000067539; ENSMUSP00000069300; ENSMUSG00000062528.
DR GeneID; 387343; -.
DR KEGG; mmu:387343; -.
DR UCSC; uc009ejx.1; mouse.
DR CTD; 387343; -.
DR MGI; MGI:2681214; Tas2r109.
DR VEuPathDB; HostDB:ENSMUSG00000062528; -.
DR eggNOG; ENOG502SKRK; Eukaryota.
DR GeneTree; ENSGT00960000186648; -.
DR HOGENOM; CLU_072337_3_0_1; -.
DR InParanoid; Q7M707; -.
DR OMA; CVIRKPL; -.
DR OrthoDB; 1010573at2759; -.
DR PhylomeDB; Q7M707; -.
DR TreeFam; TF335891; -.
DR BioGRID-ORCS; 387343; 0 hits in 71 CRISPR screens.
DR PRO; PR:Q7M707; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q7M707; protein.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0033038; F:bitter taste receptor activity; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0008527; F:taste receptor activity; ISO:MGI.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..316
FT /note="Taste receptor type 2 member 109"
FT /id="PRO_0000248254"
FT TOPO_DOM 1..14
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 15..35
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 36..62
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 84..94
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 95..115
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 116..135
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..191
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 213..241
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 263..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..316
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 170
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 316 AA; 36750 MW; 4DCC3244FA827A28 CRC64;
MEHLLKRTFD ITENILLIIL FIELIIGLIG NGFTALVHCM DWVKRKKMSL VNKILTALAT
SRIFLLWFML VGFPISSLYP YLVTTRLMIQ FTSTLWTIAN HISVWFATCL SVFYFLKIAN
FSNSPFLYLK RRVEKVVSVT LLVSLVLLFL NILLLNLEIN MCINEYHQIN ISYIFISYYH
LSCQIQVLGS HIIFLSVPVV LSLSTFLLLI FSLWTLHKRM QQHVQGGRDA RTTAHFKALQ
AVIAFLLLYS IFILSLLLQF WIHGLRKKPP FIAFCQVVDT AFPSFHSYVL ILRDRKLRHA
SLSVLSWLKC RPNYVK
