ID   TR109_RAT               Reviewed;         320 AA.
AC   Q675B9;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Taste receptor type 2 member 109;
DE            Short=T2R109;
DE   AltName: Full=Taste receptor type 2 member 38;
DE            Short=T2R38;
GN   Name=Tas2r109 {ECO:0000250|UniProtKB:Q7M707}; Synonyms=Tas2r38;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:AAS57909.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAS57909.1};
RA   Conte C., Ebeling M., Marcuz A., Andres-Barquin P.J.;
RT   "Identification of new putative rat taste receptors belonging to the T2R
RT   family.";
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative taste receptor which may play a role in the
CC       perception of bitterness. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC       taste receptor cell. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY486338; AAS57909.1; -; Genomic_DNA.
DR   RefSeq; NP_001074408.1; NM_001080939.1.
DR   AlphaFoldDB; Q675B9; -.
DR   SMR; Q675B9; -.
DR   STRING; 10116.ENSRNOP00000043062; -.
DR   GlyGen; Q675B9; 1 site.
DR   PaxDb; Q675B9; -.
DR   PRIDE; Q675B9; -.
DR   Ensembl; ENSRNOT00000045376; ENSRNOP00000043062; ENSRNOG00000032724.
DR   GeneID; 690572; -.
DR   KEGG; rno:690572; -.
DR   UCSC; RGD:1594689; rat.
DR   CTD; 387343; -.
DR   RGD; 1594689; Tas2r109.
DR   eggNOG; ENOG502SKRK; Eukaryota.
DR   GeneTree; ENSGT00960000186648; -.
DR   HOGENOM; CLU_072337_3_0_1; -.
DR   InParanoid; Q675B9; -.
DR   OMA; CVIRKPL; -.
DR   OrthoDB; 1010573at2759; -.
DR   PhylomeDB; Q675B9; -.
DR   TreeFam; TF335891; -.
DR   PRO; PR:Q675B9; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0033038; F:bitter taste receptor activity; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR007960; TAS2R.
DR   Pfam; PF05296; TAS2R; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..320
FT                   /note="Taste receptor type 2 member 109"
FT                   /id="PRO_0000248255"
FT   TOPO_DOM        1..14
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        15..35
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        36..62
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..83
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        84..94
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        116..135
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        157..191
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        213..240
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        262..270
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..291
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        292..320
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        170
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   320 AA;  37481 MW;  40DA43C3BA6911C7 CRC64;
     MEHFLKSIFD ISKNVLPIIL FIELIIGIIG NGFMALVHCM DWVKRKKMSL VNQILTTLAT
     SRICLLWFML LGLLITLLDP DLASARMMIQ VASNLWIIAN HMSIWLATCL TVFYFLKIAN
     FSSSLFLYLK WRVEKVISVI FLVSLVLLFL NMLLMNLEND MCIAEYHQIN ISYSFIYHYR
     ADCERRVLRL HIIILSVPFV LSLPTFLLLI FSLWTHHKKM QQHVQGRRDA STTAHFKALQ
     TVIAFLLLYC IFILSMLLQF WKYELMKKPL FILFCHIVYG AFPSFHSYVL ILGDMKLRQA
     SLSVLLWLKC RPNYIETLDL