TR10D_HUMAN
ID TR10D_HUMAN Reviewed; 386 AA.
AC Q9UBN6; B2R8W0; Q9Y6Q4;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 2.
DT 03-AUG-2022, entry version 187.
DE RecName: Full=Tumor necrosis factor receptor superfamily member 10D;
DE AltName: Full=Decoy receptor 2;
DE Short=DcR2;
DE AltName: Full=TNF-related apoptosis-inducing ligand receptor 4;
DE Short=TRAIL receptor 4;
DE Short=TRAIL-R4 {ECO:0000303|PubMed:9430226};
DE AltName: Full=TRAIL receptor with a truncated death domain;
DE AltName: CD_antigen=CD264;
DE Flags: Precursor;
GN Name=TNFRSF10D {ECO:0000312|HGNC:HGNC:11907};
GN Synonyms=DCR2, TRAILR4, TRUNDD {ECO:0000303|PubMed:9537512};
GN ORFNames=UNQ251/PRO288;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS, AND VARIANT
RP SER-310.
RC TISSUE=Fetal lung;
RX PubMed=9382840; DOI=10.1016/s0960-9822(06)00422-2;
RA Marsters S.A., Sheridan J.P., Pitti R.M., Huang A., Skubatch M.,
RA Baldwin D., Yuan J., Gurney A., Goddard A.D., Godowski P., Ashkenazi A.;
RT "A novel receptor for Apo2L/TRAIL contains a truncated death domain.";
RL Curr. Biol. 7:1003-1006(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, VARIANTS SER-35 AND SER-310,
RP FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Foreskin fibroblast, and Peripheral blood lymphocyte;
RX PubMed=9430226; DOI=10.1016/s1074-7613(00)80399-4;
RA Degli-Esposti M.A., Dougall W.C., Smolak P.J., Waugh J.Y., Smith C.A.,
RA Goodwin R.G.;
RT "The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-
RT mediated apoptosis, yet retains an incomplete death domain.";
RL Immunity 7:813-820(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], CHARACTERIZATION, FUNCTION, AND VARIANT
RP SER-310.
RX PubMed=9537512; DOI=10.1016/s0014-5793(98)00135-5;
RA Pan G., Ni J., Yu G.-L., Wei Y.-F., Dixit V.M.;
RT "TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL
RT signalling.";
RL FEBS Lett. 424:41-45(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-310.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-310.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT SER-310.
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PROTEIN SEQUENCE OF 56-70.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally verified
RT cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
CC -!- FUNCTION: Receptor for the cytotoxic ligand TRAIL (PubMed:9430226).
CC Contains a truncated death domain and hence is not capable of inducing
CC apoptosis but protects against TRAIL-mediated apoptosis
CC (PubMed:9537512). Reports are contradictory with regards to its ability
CC to induce the NF-kappa-B pathway. According to PubMed:9382840, it
CC cannot but according to PubMed:9430226, it can induce the NF-kappa-B
CC pathway (PubMed:9382840, PubMed:9430226). {ECO:0000269|PubMed:9382840,
CC ECO:0000269|PubMed:9430226, ECO:0000269|PubMed:9537512}.
CC -!- INTERACTION:
CC Q9UBN6; O95236-2: APOL3; NbExp=3; IntAct=EBI-1044859, EBI-11976321;
CC Q9UBN6; P53367: ARFIP1; NbExp=3; IntAct=EBI-1044859, EBI-2808808;
CC Q9UBN6; Q9H5X1: CIAO2A; NbExp=3; IntAct=EBI-1044859, EBI-752069;
CC Q9UBN6; Q5VYK3: ECPAS; NbExp=3; IntAct=EBI-1044859, EBI-521451;
CC Q9UBN6; Q8IWE2: FAM114A1; NbExp=3; IntAct=EBI-1044859, EBI-2686288;
CC Q9UBN6; Q05329: GAD2; NbExp=3; IntAct=EBI-1044859, EBI-9304251;
CC Q9UBN6; C9JCN9: HSBP1L1; NbExp=3; IntAct=EBI-1044859, EBI-2685549;
CC Q9UBN6; Q9BT40: INPP5K; NbExp=3; IntAct=EBI-1044859, EBI-749162;
CC Q9UBN6; O43561-2: LAT; NbExp=3; IntAct=EBI-1044859, EBI-8070286;
CC Q9UBN6; Q9NQG6: MIEF1; NbExp=3; IntAct=EBI-1044859, EBI-740987;
CC Q9UBN6; Q7Z6M4: MTERF4; NbExp=3; IntAct=EBI-1044859, EBI-948435;
CC Q9UBN6; P49585: PCYT1A; NbExp=3; IntAct=EBI-1044859, EBI-2563309;
CC Q9UBN6; Q9UKF7-2: PITPNC1; NbExp=3; IntAct=EBI-1044859, EBI-14223623;
CC Q9UBN6; Q8IY26: PLPP6; NbExp=3; IntAct=EBI-1044859, EBI-11721828;
CC Q9UBN6; Q9UGP5-2: POLL; NbExp=3; IntAct=EBI-1044859, EBI-10320765;
CC Q9UBN6; P09455: RBP1; NbExp=3; IntAct=EBI-1044859, EBI-2623483;
CC Q9UBN6; Q96LZ7: RMDN2; NbExp=3; IntAct=EBI-1044859, EBI-2806908;
CC Q9UBN6; Q9NTN9-2: SEMA4G; NbExp=3; IntAct=EBI-1044859, EBI-12913124;
CC Q9UBN6; Q9HC62: SENP2; NbExp=3; IntAct=EBI-1044859, EBI-714881;
CC Q9UBN6; Q92504: SLC39A7; NbExp=3; IntAct=EBI-1044859, EBI-1051105;
CC Q9UBN6; Q9P2R7: SUCLA2; NbExp=3; IntAct=EBI-1044859, EBI-2269898;
CC Q9UBN6; Q9BW92: TARS2; NbExp=3; IntAct=EBI-1044859, EBI-1045099;
CC Q9UBN6; Q969Z0: TBRG4; NbExp=3; IntAct=EBI-1044859, EBI-702328;
CC Q9UBN6; Q8WY91: THAP4; NbExp=3; IntAct=EBI-1044859, EBI-726691;
CC Q9UBN6; A0A384ME17: TUFM; NbExp=3; IntAct=EBI-1044859, EBI-12261790;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I
CC membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Widely expressed, in particular in fetal kidney,
CC lung and liver, and in adult testis and liver. Also expressed in
CC peripheral blood leukocytes, colon and small intestine, ovary,
CC prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.
CC {ECO:0000269|PubMed:9430226}.
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DR EMBL; AF029761; AAD03477.1; -; mRNA.
DR EMBL; AF021232; AAC32765.1; -; mRNA.
DR EMBL; AF021233; AAC32766.1; -; mRNA.
DR EMBL; AF023849; AAC52053.1; -; mRNA.
DR EMBL; AY358285; AAQ88652.1; -; mRNA.
DR EMBL; AK313528; BAG36307.1; -; mRNA.
DR EMBL; BC052270; AAH52270.1; -; mRNA.
DR CCDS; CCDS6038.1; -.
DR RefSeq; NP_003831.2; NM_003840.4.
DR AlphaFoldDB; Q9UBN6; -.
DR BioGRID; 114321; 45.
DR DIP; DIP-6231N; -.
DR IntAct; Q9UBN6; 31.
DR MINT; Q9UBN6; -.
DR STRING; 9606.ENSP00000310263; -.
DR GlyGen; Q9UBN6; 2 sites.
DR iPTMnet; Q9UBN6; -.
DR PhosphoSitePlus; Q9UBN6; -.
DR SwissPalm; Q9UBN6; -.
DR BioMuta; TNFRSF10D; -.
DR DMDM; 18203495; -.
DR EPD; Q9UBN6; -.
DR jPOST; Q9UBN6; -.
DR MassIVE; Q9UBN6; -.
DR MaxQB; Q9UBN6; -.
DR PaxDb; Q9UBN6; -.
DR PeptideAtlas; Q9UBN6; -.
DR PRIDE; Q9UBN6; -.
DR ProteomicsDB; 84018; -.
DR Antibodypedia; 9716; 778 antibodies from 43 providers.
DR DNASU; 8793; -.
DR Ensembl; ENST00000312584.4; ENSP00000310263.3; ENSG00000173530.6.
DR GeneID; 8793; -.
DR KEGG; hsa:8793; -.
DR MANE-Select; ENST00000312584.4; ENSP00000310263.3; NM_003840.5; NP_003831.2.
DR UCSC; uc003xcz.4; human.
DR CTD; 8793; -.
DR DisGeNET; 8793; -.
DR GeneCards; TNFRSF10D; -.
DR HGNC; HGNC:11907; TNFRSF10D.
DR HPA; ENSG00000173530; Low tissue specificity.
DR MIM; 603614; gene.
DR neXtProt; NX_Q9UBN6; -.
DR OpenTargets; ENSG00000173530; -.
DR PharmGKB; PA36600; -.
DR VEuPathDB; HostDB:ENSG00000173530; -.
DR eggNOG; ENOG502RBEC; Eukaryota.
DR GeneTree; ENSGT00940000164831; -.
DR HOGENOM; CLU_038161_0_0_1; -.
DR InParanoid; Q9UBN6; -.
DR OrthoDB; 1448442at2759; -.
DR PhylomeDB; Q9UBN6; -.
DR TreeFam; TF333916; -.
DR PathwayCommons; Q9UBN6; -.
DR Reactome; R-HSA-202733; Cell surface interactions at the vascular wall.
DR Reactome; R-HSA-6803211; TP53 Regulates Transcription of Death Receptors and Ligands.
DR Reactome; R-HSA-75158; TRAIL signaling.
DR SignaLink; Q9UBN6; -.
DR SIGNOR; Q9UBN6; -.
DR BioGRID-ORCS; 8793; 8 hits in 1073 CRISPR screens.
DR ChiTaRS; TNFRSF10D; human.
DR GeneWiki; TNFRSF10D; -.
DR GenomeRNAi; 8793; -.
DR Pharos; Q9UBN6; Tbio.
DR PRO; PR:Q9UBN6; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q9UBN6; protein.
DR Bgee; ENSG00000173530; Expressed in cartilage tissue and 145 other tissues.
DR Genevisible; Q9UBN6; HS.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0045569; F:TRAIL binding; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0043066; P:negative regulation of apoptotic process; TAS:ProtInc.
DR GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR CDD; cd10580; TNFRSF10; 1.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR020465; TNFR_10.
DR InterPro; IPR034024; TNFRSF10_N.
DR Pfam; PF00020; TNFR_c6; 2.
DR PRINTS; PR01956; TNFACTORR10.
DR SMART; SM00208; TNFR; 2.
DR PROSITE; PS00652; TNFR_NGFR_1; 2.
DR PROSITE; PS50050; TNFR_NGFR_2; 2.
PE 1: Evidence at protein level;
KW Apoptosis; Direct protein sequencing; Disulfide bond; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..55
FT /evidence="ECO:0000269|PubMed:15340161,
FT ECO:0000269|PubMed:9382840"
FT CHAIN 56..386
FT /note="Tumor necrosis factor receptor superfamily member
FT 10D"
FT /id="PRO_0000034584"
FT TOPO_DOM 56..211
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 233..386
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 58..97
FT /note="TNFR-Cys 1"
FT REPEAT 98..139
FT /note="TNFR-Cys 2"
FT REPEAT 140..180
FT /note="TNFR-Cys 3"
FT DOMAIN 340..366
FT /note="Death; truncated"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 62..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 127
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 182
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 83..96
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 99..115
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 118..131
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 121..139
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 141..155
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 158..172
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT DISULFID 162..180
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00206"
FT VARIANT 35
FT /note="P -> S (in dbSNP:rs11135703)"
FT /evidence="ECO:0000269|PubMed:9430226"
FT /id="VAR_011417"
FT VARIANT 276
FT /note="R -> H (in dbSNP:rs55636833)"
FT /id="VAR_061854"
FT VARIANT 310
FT /note="L -> S (in dbSNP:rs1133782)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:9382840, ECO:0000269|PubMed:9430226,
FT ECO:0000269|PubMed:9537512"
FT /id="VAR_011418"
FT VARIANT 345
FT /note="T -> P (in dbSNP:rs34622674)"
FT /id="VAR_057288"
SQ SEQUENCE 386 AA; 41849 MW; 8D15E577D214852A CRC64;
MGLWGQSVPT ASSARAGRYP GARTASGTRP WLLDPKILKF VVFIVAVLLP VRVDSATIPR
QDEVPQQTVA PQQQRRSLKE EECPAGSHRS EYTGACNPCT EGVDYTIASN NLPSCLLCTV
CKSGQTNKSS CTTTRDTVCQ CEKGSFQDKN SPEMCRTCRT GCPRGMVKVS NCTPRSDIKC
KNESAASSTG KTPAAEETVT TILGMLASPY HYLIIIVVLV IILAVVVVGF SCRKKFISYL
KGICSGGGGG PERVHRVLFR RRSCPSRVPG AEDNARNETL SNRYLQPTQV SEQEIQGQEL
AELTGVTVEL PEEPQRLLEQ AEAEGCQRRR LLVPVNDADS ADISTLLDAS ATLEEGHAKE
TIQDQLVGSE KLFYEEDEAG SATSCL
