TR110_MOUSE
ID TR110_MOUSE Reviewed; 333 AA.
AC Q7M712; Q71QD1;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Taste receptor type 2 member 110;
DE Short=T2R110;
DE Short=mT2r57;
DE AltName: Full=STC 9-1;
GN Name=Tas2r110 {ECO:0000312|MGI:MGI:2681216};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAL85201.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11854532; DOI=10.1073/pnas.042617699;
RA Wu S.V., Rozengurt N., Yang M., Young S.H., Sinnett-Smith J., Rozengurt E.;
RT "Expression of bitter taste receptors of the T2R family in the
RT gastrointestinal tract and enteroendocrine STC-1 cells.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:2392-2397(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000305, ECO:0000312|EMBL:DAA01224.1}
RP IDENTIFICATION.
RX PubMed=12679530; DOI=10.1093/molbev/msg083;
RA Shi P., Zhang J., Yang H., Zhang Y.-P.;
RT "Adaptive diversification of bitter taste receptor genes in mammalian
RT evolution.";
RL Mol. Biol. Evol. 20:805-814(2003).
CC -!- FUNCTION: Gustducin-coupled receptor implicated in the perception of
CC bitter compounds in the oral cavity and the gastrointestinal tract.
CC Signals through PLCB2 and the calcium-regulated cation channel TRPM5
CC (By similarity). {ECO:0000250|UniProtKB:Q9JKE8}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Several bitter taste receptors with distinct ligand
CC specificities are expressed in a single taste receptor cell.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000255}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF412304; AAL85201.1; -; Genomic_DNA.
DR EMBL; AC129318; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK001085; DAA01224.1; -; Genomic_DNA.
DR CCDS; CCDS20626.1; -.
DR RefSeq; NP_954606.2; NM_199155.2.
DR AlphaFoldDB; Q7M712; -.
DR STRING; 10090.ENSMUSP00000080674; -.
DR GlyGen; Q7M712; 2 sites.
DR PaxDb; Q7M712; -.
DR PRIDE; Q7M712; -.
DR DNASU; 387344; -.
DR Ensembl; ENSMUST00000082014; ENSMUSP00000080674; ENSMUSG00000062952.
DR GeneID; 387344; -.
DR KEGG; mmu:387344; -.
DR UCSC; uc009ejs.1; mouse.
DR CTD; 387344; -.
DR MGI; MGI:2681216; Tas2r110.
DR VEuPathDB; HostDB:ENSMUSG00000062952; -.
DR eggNOG; ENOG502SKRK; Eukaryota.
DR GeneTree; ENSGT00960000186648; -.
DR HOGENOM; CLU_072337_3_0_1; -.
DR InParanoid; Q7M712; -.
DR OMA; ANLMEFR; -.
DR OrthoDB; 1053374at2759; -.
DR PhylomeDB; Q7M712; -.
DR TreeFam; TF335891; -.
DR BioGRID-ORCS; 387344; 3 hits in 70 CRISPR screens.
DR PRO; PR:Q7M712; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q7M712; protein.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0033038; F:bitter taste receptor activity; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0008527; F:taste receptor activity; ISO:MGI.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..333
FT /note="Taste receptor type 2 member 110"
FT /id="PRO_0000247660"
FT TOPO_DOM 1..13
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 14..34
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 35..60
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..89
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 90..110
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 111..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..205
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..255
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 256..276
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 277..283
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 305..333
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 186
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 195
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 151
FT /note="L -> V (in Ref. 1; AAL85201)"
FT /evidence="ECO:0000305"
FT CONFLICT 169
FT /note="S -> F (in Ref. 1; AAL85201)"
FT /evidence="ECO:0000305"
FT CONFLICT 230
FT /note="H -> R (in Ref. 1; AAL85201)"
FT /evidence="ECO:0000305"
FT CONFLICT 256
FT /note="F -> L (in Ref. 1; AAL85201)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 333 AA; 37837 MW; EF9F34637BAD54EC CRC64;
MFSQIISTSD IFTFTIILFV ELVIGILGNG FIALVNIMDW TKRRSISSAD QILTALAITR
FLYVWFMIIC ILLFMLCPHL LTRSEIVTSI GIIWIVNNHF SVWLATCLGV FYFLKIANFS
NSLFLYLKWR VKKVVLMIIQ VSMIFLILNL LSLSMYDQFS IDVYEGNTSY NLGDSTPFPT
ISLFINSSKV FVITNSSHIF LPINSLFMLI PFTVSLVAFL MLIFSLWKHH KKMQVNAKPP
RDASTMAHIK ALQTGFSFLL LYAVYLLFIV IGMLSLRLIG GKLILLFDHI SGIGFPISHS
FVLILGNNKL RQASLSVLHC LRCRSKDMDT MGP
