TR110_RAT
ID TR110_RAT Reviewed; 333 AA.
AC Q9JKE8; Q67ET8;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 2.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Taste receptor type 2 member 110;
DE Short=T2R110;
DE AltName: Full=Taste receptor type 2 member 10;
DE Short=T2R10;
GN Name=Tas2r110; Synonyms=Tas2r10;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Sprague-Dawley;
RA Conte C., Ebeling M., Marcuz A., Andres-Barquin P.J.;
RT "Identification of new putative rat taste receptors belonging to the T2R
RT family.";
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-131, AND TOPOLOGY.
RX PubMed=10761934; DOI=10.1016/s0092-8674(00)80705-9;
RA Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P.,
RA Zuker C.S.;
RT "A novel family of mammalian taste receptors.";
RL Cell 100:693-702(2000).
RN [3]
RP CHARACTERIZATION.
RX PubMed=10761935; DOI=10.1016/s0092-8674(00)80706-0;
RA Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W.,
RA Zuker C.S., Ryba N.J.P.;
RT "T2Rs function as bitter taste receptors.";
RL Cell 100:703-711(2000).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=11854532; DOI=10.1073/pnas.042617699;
RA Wu S.V., Rozengurt N., Yang M., Young S.H., Sinnett-Smith J., Rozengurt E.;
RT "Expression of bitter taste receptors of the T2R family in the
RT gastrointestinal tract and enteroendocrine STC-1 cells.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:2392-2397(2002).
RN [5]
RP REVIEW.
RX PubMed=12139982; DOI=10.1016/s0959-4388(02)00345-8;
RA Montmayeur J.-P., Matsunami H.;
RT "Receptors for bitter and sweet taste.";
RL Curr. Opin. Neurobiol. 12:366-371(2002).
RN [6]
RP REVIEW.
RX PubMed=11696554; DOI=10.1074/jbc.r100054200;
RA Margolskee R.F.;
RT "Molecular mechanisms of bitter and sweet taste transduction.";
RL J. Biol. Chem. 277:1-4(2002).
RN [7]
RP REVIEW.
RX PubMed=12581520; DOI=10.1016/s0092-8674(03)00071-0;
RA Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D.,
RA Zuker C.S., Ryba N.J.;
RT "Coding of sweet, bitter, and umami tastes: different receptor cells
RT sharing similar signaling pathways.";
RL Cell 112:293-301(2003).
CC -!- FUNCTION: Gustducin-coupled receptor implicated in the perception of
CC bitter compounds in the oral cavity and the gastrointestinal tract.
CC Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the
CC tongue and palate epithelium and exclusively in gustducin-positive
CC cells. Expressed in 15% taste bud cells in circumvallate and foliate
CC papillae but only in 2% in fungiform papillae.
CC {ECO:0000269|PubMed:11854532}.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
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DR EMBL; AY362732; AAR13341.1; -; Genomic_DNA.
DR EMBL; AF240767; AAF45305.1; -; mRNA.
DR RefSeq; NP_001160149.1; NM_001166677.1.
DR AlphaFoldDB; Q9JKE8; -.
DR STRING; 10116.ENSRNOP00000047747; -.
DR GlyGen; Q9JKE8; 3 sites.
DR PaxDb; Q9JKE8; -.
DR GeneID; 100310875; -.
DR KEGG; rno:100310875; -.
DR UCSC; RGD:2314263; rat.
DR CTD; 387344; -.
DR RGD; 2314263; Tas2r110.
DR eggNOG; ENOG502SKRK; Eukaryota.
DR InParanoid; Q9JKE8; -.
DR OrthoDB; 1053374at2759; -.
DR PhylomeDB; Q9JKE8; -.
DR PRO; PR:Q9JKE8; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0033038; F:bitter taste receptor activity; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0008527; F:taste receptor activity; TAS:UniProtKB.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
PE 1: Evidence at protein level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..333
FT /note="Taste receptor type 2 member 110"
FT /id="PRO_0000082244"
FT TOPO_DOM 1..14
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 15..35
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 36..60
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..90
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..134
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..205
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..253
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 275..283
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 305..333
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 167
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 186
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 195
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 333 AA; 38406 MW; 6D5A6F5DC110214C CRC64;
MFLHTIKQRD IFTLIIIFFV EITMGILGNG FIALVNIVDW IKRRRISSVD KILTTLALTR
LIYAWSMLIF ILLFILGPHL IMRSEILTSM GVIWVVNNHF SIWLATCLGV FYFLKIANFS
NSLFLYLKWR VKKVVLMIIV VSLIFLILNI FSLEIYDHFS IDVYEGNMSY SLGDSTHFPR
IFLFANSSKV FLITNSSQVF LPINSLFMLI PFTVSLVAFF MLIFSLWKHH KKMEVNAKGP
RDASTTAHIK ALQTGLSFLL LYAIYLLFIV IGILSHKFMG GKLILIFDHI CAIVFPISHS
FVLILGNSKL RRSTLSVLRF LRCRSKHIHI MDP
