ID   TR112_BOVIN             Reviewed;         125 AA.
AC   Q2KIA2;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Multifunctional methyltransferase subunit TRM112-like protein;
DE   AltName: Full=tRNA methyltransferase 112 homolog;
GN   Name=TRMT112;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as an activator of both rRNA/tRNA and protein
CC       methyltransferases. Together with methyltransferase BUD23, methylates
CC       the N(7) position of a guanine in 18S rRNA. The heterodimer with
CC       HEMK2/N6AMT1 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-
CC       adenosyl L-methionine as methyl donor. The heterodimer with ALKBH8
CC       catalyzes the methylation of 5-carboxymethyl uridine to 5-
CC       methylcarboxymethyl uridine at the wobble position of the anticodon
CC       loop in target tRNA species. Together with methyltransferase THUMPD3,
CC       catalyzes the formation of N(2)-methylguanosine at position 6 in a
CC       broad range of tRNA substrates and at position 7 of tRNA(Trp) (By
CC       similarity). Involved in the pre-rRNA processing steps leading to
CC       small-subunit rRNA production. Together with methyltransferase METTL5,
CC       specifically methylates the 6th position of adenine in position 1832 of
CC       18S rRNA. {ECO:0000250|UniProtKB:Q9UI30}.
CC   -!- SUBUNIT: Heterodimer with BUD23/WBSCR22; this heterodimerization is
CC       necessary for the metabolic stability and activity of the catalytic
CC       subunit BUD23 (By similarity). Heterodimer with N6AMT1/HEMK2; this
CC       heterodimerization is necessary for S-adenosyl-L-methionine-binding to
CC       N6AMT1/HEMK2 (By similarity). Heterodimer with ALKBH8 (By similarity).
CC       Heterodimer with METTL5; this heterodimerization is necessary for the
CC       stability of the catalytic subunit METTL5 (By similarity). Interacts
CC       with THUMPD3; the interaction is direct and is required for THUMPD3
CC       methyltransferase activity (By similarity). Interacts with THUMPD2 (By
CC       similarity). {ECO:0000250|UniProtKB:Q9UI30}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC       {ECO:0000250|UniProtKB:Q9UI30}. Cytoplasm, perinuclear region
CC       {ECO:0000250|UniProtKB:Q9UI30}. Note=Localizes to a polarized
CC       perinuclear structure, overlapping partially with the Golgi and
CC       lysosomes. {ECO:0000250|UniProtKB:Q9UI30}.
CC   -!- SIMILARITY: Belongs to the TRM112 family. {ECO:0000305}.
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DR   EMBL; BC112713; AAI12714.1; -; mRNA.
DR   RefSeq; NP_001039446.1; NM_001045981.2.
DR   AlphaFoldDB; Q2KIA2; -.
DR   SMR; Q2KIA2; -.
DR   STRING; 9913.ENSBTAP00000011401; -.
DR   PaxDb; Q2KIA2; -.
DR   PRIDE; Q2KIA2; -.
DR   Ensembl; ENSBTAT00000011401; ENSBTAP00000011401; ENSBTAG00000008646.
DR   GeneID; 507833; -.
DR   KEGG; bta:507833; -.
DR   CTD; 51504; -.
DR   VEuPathDB; HostDB:ENSBTAG00000008646; -.
DR   eggNOG; KOG1088; Eukaryota.
DR   GeneTree; ENSGT00390000009268; -.
DR   HOGENOM; CLU_086140_2_0_1; -.
DR   InParanoid; Q2KIA2; -.
DR   OMA; NMLTSKC; -.
DR   OrthoDB; 1465773at2759; -.
DR   TreeFam; TF313256; -.
DR   Proteomes; UP000009136; Chromosome 29.
DR   Bgee; ENSBTAG00000008646; Expressed in oocyte and 106 other tissues.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR   GO; GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
DR   GO; GO:0034968; P:histone lysine methylation; ISS:UniProtKB.
DR   GO; GO:0018364; P:peptidyl-glutamine methylation; ISS:UniProtKB.
DR   GO; GO:2000234; P:positive regulation of rRNA processing; ISS:UniProtKB.
DR   GO; GO:0070476; P:rRNA (guanine-N7)-methylation; ISS:UniProtKB.
DR   GO; GO:0031167; P:rRNA methylation; ISS:UniProtKB.
DR   GO; GO:0030488; P:tRNA methylation; IBA:GO_Central.
DR   GO; GO:0002940; P:tRNA N2-guanine methylation; ISS:UniProtKB.
DR   InterPro; IPR039127; Trm112.
DR   InterPro; IPR005651; Trm112-like.
DR   PANTHER; PTHR12773; PTHR12773; 1.
DR   Pfam; PF03966; Trm112p; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..125
FT                   /note="Multifunctional methyltransferase subunit TRM112-
FT                   like protein"
FT                   /id="PRO_0000247891"
FT   DOMAIN          2..119
FT                   /note="TRM112"
FT   MOD_RES         119
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9UI30"
SQ   SEQUENCE   125 AA;  14320 MW;  6AD0EC9E7A15B71B CRC64;
     MRLLTHNLLS SHVRGVGPRG FPLRLQATEV RINPVEFNPD FIVRMIPKVE WAALLEAADH
     LHLIQVPKEP IQGYEHNEEF LRKMHHVLLE VEVLEGTLQC PESGRVFPIS RGIPNMLLSD
     EETET