ID   TR112_DICDI             Reviewed;         128 AA.
AC   Q54N57;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Multifunctional methyltransferase subunit TRM112-like protein;
DE   AltName: Full=tRNA methyltransferase 112 homolog;
GN   ORFNames=DDB_G0285489;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Acts as an activator of both RNA and protein
CC       methyltransferases. {ECO:0000250|UniProtKB:Q9UI30}.
CC   -!- SIMILARITY: Belongs to the TRM112 family. {ECO:0000305}.
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DR   EMBL; AAFI02000079; EAL64582.1; -; Genomic_DNA.
DR   RefSeq; XP_638086.1; XM_632994.1.
DR   AlphaFoldDB; Q54N57; -.
DR   SMR; Q54N57; -.
DR   STRING; 44689.DDB0186528; -.
DR   PaxDb; Q54N57; -.
DR   EnsemblProtists; EAL64582; EAL64582; DDB_G0285489.
DR   GeneID; 8625132; -.
DR   KEGG; ddi:DDB_G0285489; -.
DR   dictyBase; DDB_G0285489; -.
DR   eggNOG; KOG1088; Eukaryota.
DR   HOGENOM; CLU_086140_2_1_1; -.
DR   InParanoid; Q54N57; -.
DR   OMA; NMLTSKC; -.
DR   PhylomeDB; Q54N57; -.
DR   Reactome; R-DDI-156581; Methylation.
DR   Reactome; R-DDI-72764; Eukaryotic Translation Termination.
DR   PRO; PR:Q54N57; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0018364; P:peptidyl-glutamine methylation; IBA:GO_Central.
DR   GO; GO:0070476; P:rRNA (guanine-N7)-methylation; IBA:GO_Central.
DR   GO; GO:0030488; P:tRNA methylation; IBA:GO_Central.
DR   InterPro; IPR039127; Trm112.
DR   InterPro; IPR005651; Trm112-like.
DR   PANTHER; PTHR12773; PTHR12773; 1.
DR   Pfam; PF03966; Trm112p; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..128
FT                   /note="Multifunctional methyltransferase subunit TRM112-
FT                   like protein"
FT                   /id="PRO_0000331129"
FT   DOMAIN          2..111
FT                   /note="TRM112"
SQ   SEQUENCE   128 AA;  14923 MW;  6AE602EFA45899DC CRC64;
     MKILTHNMMA CTKKQCMGKG FPLKVESTEQ IVLEQEFNYE FTKNIYPKLD WLGIAEISIK
     FNIPIQLDTT KHSLEDEEFL KTLHNLLCNL KVITGSLTCP NCQRVYPIDK GIPNMLLRED
     EIYQEIKE