ID   TR112_DROME             Reviewed;         124 AA.
AC   Q9VP65;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Multifunctional methyltransferase subunit TRM112-like protein;
DE   AltName: Full=tRNA methyltransferase 112 homolog;
GN   ORFNames=CG12975;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [4]
RP   FUNCTION, AND INTERACTION WITH CG9666.
RX   PubMed=32350990; DOI=10.15252/embr.201949443;
RA   Leismann J., Spagnuolo M., Pradhan M., Wacheul L., Vu M.A., Musheev M.,
RA   Mier P., Andrade-Navarro M.A., Graille M., Niehrs C., Lafontaine D.L.,
RA   Roignant J.Y.;
RT   "The 18S ribosomal RNA m6 A methyltransferase Mettl5 is required for normal
RT   walking behavior in Drosophila.";
RL   EMBO Rep. 21:e49443-e49443(2020).
CC   -!- FUNCTION: Acts as an activator of both RNA and protein
CC       methyltransferases (By similarity). Together with methyltransferase
CC       Mettl5/CG9666, specifically methylates the 6th position of adenine in
CC       18S rRNA (PubMed:32350990). {ECO:0000250|UniProtKB:Q9UI30,
CC       ECO:0000269|PubMed:32350990}.
CC   -!- SUBUNIT: Heterodimer with Mettl5/CG9666. {ECO:0000269|PubMed:32350990}.
CC   -!- INTERACTION:
CC       Q9VP65; A1ZBT5: MED8; NbExp=3; IntAct=EBI-141782, EBI-90766;
CC   -!- SIMILARITY: Belongs to the TRM112 family. {ECO:0000305}.
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DR   EMBL; AE014296; AAF51690.1; -; Genomic_DNA.
DR   EMBL; AY071539; AAL49161.1; -; mRNA.
DR   RefSeq; NP_649293.1; NM_141036.4.
DR   AlphaFoldDB; Q9VP65; -.
DR   SMR; Q9VP65; -.
DR   BioGRID; 65592; 6.
DR   IntAct; Q9VP65; 1.
DR   STRING; 7227.FBpp0077965; -.
DR   PaxDb; Q9VP65; -.
DR   PRIDE; Q9VP65; -.
DR   DNASU; 40343; -.
DR   EnsemblMetazoa; FBtr0078309; FBpp0077965; FBgn0037061.
DR   GeneID; 40343; -.
DR   KEGG; dme:Dmel_CG12975; -.
DR   UCSC; CG12975-RA; d. melanogaster.
DR   FlyBase; FBgn0037061; CG12975.
DR   VEuPathDB; VectorBase:FBgn0037061; -.
DR   eggNOG; KOG1088; Eukaryota.
DR   GeneTree; ENSGT00940000164608; -.
DR   HOGENOM; CLU_086140_2_0_1; -.
DR   InParanoid; Q9VP65; -.
DR   OMA; NMLTSKC; -.
DR   OrthoDB; 1465773at2759; -.
DR   PhylomeDB; Q9VP65; -.
DR   Reactome; R-DME-156581; Methylation.
DR   Reactome; R-DME-72764; Eukaryotic Translation Termination.
DR   BioGRID-ORCS; 40343; 0 hits in 1 CRISPR screen.
DR   GenomeRNAi; 40343; -.
DR   PRO; PR:Q9VP65; -.
DR   Proteomes; UP000000803; Chromosome 3L.
DR   Bgee; FBgn0037061; Expressed in adult abdomen and 22 other tissues.
DR   ExpressionAtlas; Q9VP65; baseline and differential.
DR   Genevisible; Q9VP65; DM.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0018364; P:peptidyl-glutamine methylation; IBA:GO_Central.
DR   GO; GO:0070476; P:rRNA (guanine-N7)-methylation; IBA:GO_Central.
DR   GO; GO:0031167; P:rRNA methylation; IDA:UniProtKB.
DR   GO; GO:0030488; P:tRNA methylation; IBA:GO_Central.
DR   InterPro; IPR039127; Trm112.
DR   InterPro; IPR005651; Trm112-like.
DR   PANTHER; PTHR12773; PTHR12773; 1.
DR   Pfam; PF03966; Trm112p; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..124
FT                   /note="Multifunctional methyltransferase subunit TRM112-
FT                   like protein"
FT                   /id="PRO_0000215800"
FT   DOMAIN          2..120
FT                   /note="TRM112"
SQ   SEQUENCE   124 AA;  13920 MW;  3C37D84DEAF8767F CRC64;
     MKLSTYNFLT SVAIKGVKVG FPLKLTINKK EVVESEFNPT FVERILPKLD WSAVYGAAQV
     AELTEDIPAV QPENIVENEL LLQKLHHLLF EIDVLEGQLE CPETGRVFPI SDGIPNMLLN
     EDEV