TR112_NEUCR
ID TR112_NEUCR Reviewed; 127 AA.
AC Q8X0S4;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Multifunctional methyltransferase subunit trm112;
DE AltName: Full=RNA methyltransferase 1;
DE AltName: Full=eRF1 methyltransferase subunit trm112;
DE Short=eRF1 MTase subunit trm112;
DE AltName: Full=tRNA methyltransferase 112 homolog;
GN Name=rmt-1; Synonyms=trm112; ORFNames=18F11.160, NCU01201;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12655011; DOI=10.1093/nar/gkg293;
RA Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT genome sequence.";
RL Nucleic Acids Res. 31:1944-1954(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Acts as an activator of both rRNA/tRNA and protein
CC methyltransferases. Together with methyltransferase mtq2, required for
CC the methylation of eRF1 on 'Gln-182'. Together with methyltransferase
CC trm11, required for the formation of 2-methylguanosine at position 10
CC (m2G10) in tRNA. Together with methyltransferase bud23, required for
CC the formation of a 7-methylguanine in 18S rRNA. Involved in biogenesis
CC of both 40S and 60S ribosomal subunits (By similarity).
CC {ECO:0000250|UniProtKB:P53738}.
CC -!- SUBUNIT: Heterodimer of mtq2-rmt-1/trm112, forming the eRF1
CC methyltransferase. Rmt-1/trm112 is necessary for the solubility and
CC activity of the catalytic subunit mtq2. Interacts with trm11; required
CC for full tRNA methyltransferase activity. Interacts with bud23;
CC required for full rRNA methyltransferase activity (By similarity).
CC {ECO:0000250|UniProtKB:P53738}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P53738}. Nucleus
CC {ECO:0000250|UniProtKB:P53738}.
CC -!- SIMILARITY: Belongs to the TRM112 family. {ECO:0000305}.
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DR EMBL; AL670011; CAD21420.1; -; Genomic_DNA.
DR EMBL; CM002240; EAA32331.1; -; Genomic_DNA.
DR RefSeq; XP_961567.1; XM_956474.2.
DR AlphaFoldDB; Q8X0S4; -.
DR SMR; Q8X0S4; -.
DR STRING; 5141.EFNCRP00000004358; -.
DR EnsemblFungi; EAA32331; EAA32331; NCU01201.
DR GeneID; 3877690; -.
DR KEGG; ncr:NCU01201; -.
DR VEuPathDB; FungiDB:NCU01201; -.
DR HOGENOM; CLU_086140_0_0_1; -.
DR InParanoid; Q8X0S4; -.
DR OMA; NMLTSKC; -.
DR Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0035657; C:eRF1 methyltransferase complex; IEA:EnsemblFungi.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043528; C:tRNA (m2G10) methyltransferase complex; IEA:EnsemblFungi.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0008276; F:protein methyltransferase activity; IEA:EnsemblFungi.
DR GO; GO:0016435; F:rRNA (guanine) methyltransferase activity; IEA:EnsemblFungi.
DR GO; GO:0004809; F:tRNA (guanine-N2-)-methyltransferase activity; IEA:EnsemblFungi.
DR GO; GO:0000470; P:maturation of LSU-rRNA; IEA:EnsemblFungi.
DR GO; GO:0030490; P:maturation of SSU-rRNA; IEA:EnsemblFungi.
DR GO; GO:0018364; P:peptidyl-glutamine methylation; IBA:GO_Central.
DR GO; GO:0070476; P:rRNA (guanine-N7)-methylation; IBA:GO_Central.
DR GO; GO:0030488; P:tRNA methylation; IBA:GO_Central.
DR GO; GO:0002098; P:tRNA wobble uridine modification; IEA:EnsemblFungi.
DR InterPro; IPR039127; Trm112.
DR InterPro; IPR005651; Trm112-like.
DR PANTHER; PTHR12773; PTHR12773; 1.
DR Pfam; PF03966; Trm112p; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..127
FT /note="Multifunctional methyltransferase subunit trm112"
FT /id="PRO_0000215803"
FT DOMAIN 2..123
FT /note="TRM112"
SQ SEQUENCE 127 AA; 14151 MW; 4B3A855E67CA115B CRC64;
MKVMTLNFLT CAVKNCKSSN DSFPLHPKEA ELAKDDIEIN PQLLINVLPR IDWAALRTTS
TELGFPTLPE QPPSPEDLQS DEALLKELHE LLMETQMMEG KLVCGHCGHE YAVKNGVANF
LLPSHLV
