TR113_MOUSE
ID TR113_MOUSE Reviewed; 309 AA.
AC Q7M711;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Taste receptor type 2 member 113;
DE Short=T2R113;
DE Short=mT2R58;
GN Name=Tas2r113 {ECO:0000312|MGI:MGI:2681217};
GN Synonyms=T2r58 {ECO:0000303|PubMed:12679530};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000312|EMBL:DAA01225.1}
RP IDENTIFICATION.
RX PubMed=12679530; DOI=10.1093/molbev/msg083;
RA Shi P., Zhang J., Yang H., Zhang Y.-P.;
RT "Adaptive diversification of bitter taste receptor genes in mammalian
RT evolution.";
RL Mol. Biol. Evol. 20:805-814(2003).
CC -!- FUNCTION: Putative taste receptor which may play a role in the
CC perception of bitterness. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000255}.
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DR EMBL; AC129318; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK001086; DAA01225.1; -; Genomic_DNA.
DR CCDS; CCDS20627.1; -.
DR RefSeq; NP_996901.1; NM_207018.1.
DR AlphaFoldDB; Q7M711; -.
DR SMR; Q7M711; -.
DR STRING; 10090.ENSMUSP00000078044; -.
DR GlyGen; Q7M711; 1 site.
DR PaxDb; Q7M711; -.
DR PRIDE; Q7M711; -.
DR DNASU; 387345; -.
DR Ensembl; ENSMUST00000079035; ENSMUSP00000078044; ENSMUSG00000056926.
DR GeneID; 387345; -.
DR KEGG; mmu:387345; -.
DR UCSC; uc009ejt.1; mouse.
DR CTD; 387345; -.
DR MGI; MGI:2681217; Tas2r113.
DR VEuPathDB; HostDB:ENSMUSG00000056926; -.
DR eggNOG; ENOG502SKRK; Eukaryota.
DR GeneTree; ENSGT00960000186648; -.
DR HOGENOM; CLU_072337_3_0_1; -.
DR InParanoid; Q7M711; -.
DR OMA; PERYLIF; -.
DR OrthoDB; 1053374at2759; -.
DR PhylomeDB; Q7M711; -.
DR TreeFam; TF335891; -.
DR BioGRID-ORCS; 387345; 3 hits in 73 CRISPR screens.
DR PRO; PR:Q7M711; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q7M711; protein.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0033038; F:bitter taste receptor activity; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0008527; F:taste receptor activity; ISO:MGI.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..309
FT /note="Taste receptor type 2 member 113"
FT /id="PRO_0000248256"
FT TOPO_DOM 1..10
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 32..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..80
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..127
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..185
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 207..229
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 251..262
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 162
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 309 AA; 36376 MW; 54BB402412C46199 CRC64;
MVAVLQSTLP IIFSMEFIMG TLGNGFIFLI VCIDWVQRRK ISLVDQIRTA LAISRIALIW
LIFLDWWVSV HYPALHETGK MLSTYLISWT VINHCNFWLT ANLSILYFLK IANFSNIIFL
YLKFRSKNVV LVTLLVSLFF LFLNTVIIKI FSDVCFDSVQ RNVSQIFIMY NHEQICKFLS
FTNPMFTFIP FVMSTVMFSL LIFSLWRHLK NMQHTAKGCR DISTTVHIRA LQTIIVSVVL
YTIFFLSFFV KVWSFVSPER YLIFLFVWAL GNAVFSAHPF VMILVNRRLR LASLSLIFWL
WYRFKNIEV
