ID   TR113_RAT               Reviewed;         309 AA.
AC   Q67ES1;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Taste receptor type 2 member 113;
DE            Short=T2R113;
DE   AltName: Full=Taste receptor type 2 member 30;
DE            Short=T2R30;
GN   Name=Tas2r113 {ECO:0000250|UniProtKB:Q7M711}; Synonyms=Tas2r30;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:AAR13358.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAR13358.1};
RA   Conte C., Ebeling M., Marcuz A., Andres-Barquin P.J.;
RT   "Identification of new putative rat taste receptors belonging to the T2R
RT   family.";
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative taste receptor which may play a role in the
CC       perception of bitterness. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC       taste receptor cell. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000255}.
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DR   EMBL; AY362749; AAR13358.1; -; Genomic_DNA.
DR   RefSeq; NP_001160161.1; NM_001166689.1.
DR   AlphaFoldDB; Q67ES1; -.
DR   SMR; Q67ES1; -.
DR   STRING; 10116.ENSRNOP00000051522; -.
DR   GlyGen; Q67ES1; 1 site.
DR   PaxDb; Q67ES1; -.
DR   Ensembl; ENSRNOT00000050409; ENSRNOP00000051522; ENSRNOG00000030752.
DR   GeneID; 100310885; -.
DR   KEGG; rno:100310885; -.
DR   UCSC; RGD:2314255; rat.
DR   CTD; 387345; -.
DR   RGD; 2314255; Tas2r113.
DR   eggNOG; ENOG502SKRK; Eukaryota.
DR   GeneTree; ENSGT00960000186648; -.
DR   HOGENOM; CLU_072337_3_0_1; -.
DR   InParanoid; Q67ES1; -.
DR   OMA; PERYLIF; -.
DR   OrthoDB; 1053374at2759; -.
DR   PhylomeDB; Q67ES1; -.
DR   TreeFam; TF335891; -.
DR   PRO; PR:Q67ES1; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0033038; F:bitter taste receptor activity; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR   InterPro; IPR007960; TAS2R.
DR   Pfam; PF05296; TAS2R; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..309
FT                   /note="Taste receptor type 2 member 113"
FT                   /id="PRO_0000248257"
FT   TOPO_DOM        1..8
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        9..29
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        30..55
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        77..101
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        123..127
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..148
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        149..185
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        207..229
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..250
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        251..262
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        284..309
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        162
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   309 AA;  36021 MW;  D0871850D757CC17 CRC64;
     MVAVLQSTFA IIFSMEFIVG TLGNGFIILM TCIDWVRRRK ISLVDQILTA LAITRITLIL
     LVFIDWWVSV LFPALHETGK ILRMYFISWT VINHCNLWLT ASLSIIYFLK IASFSSIIFL
     YLKFRVKNVV FVTLLVSLFF LFINTAIVNV YFDVCFDGVQ RNVSQVSRLY NHEQICKFLS
     FTNPMFAFIP FVTSMATFFL LIFSLWRHLK NMKHNAEGCR DVSTIVHIRA LQTIIVSVVL
     YSTFFLSFFV KVWSSGSPER YLIFLFVWAL GNAVLPAHTF VLIWGNCRLR WASLSLMLWL
     RYRFKNIDV