TR114_MOUSE
ID TR114_MOUSE Reviewed; 309 AA.
AC Q7M722;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=Taste receptor type 2 member 114;
DE Short=T2R114;
DE Short=mT2R46;
GN Name=Tas2r114 {ECO:0000312|MGI:MGI:2681218};
GN Synonyms=T2r46 {ECO:0000303|PubMed:12679530};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000305, ECO:0000312|EMBL:DAA01214.1}
RP IDENTIFICATION.
RX PubMed=12679530; DOI=10.1093/molbev/msg083;
RA Shi P., Zhang J., Yang H., Zhang Y.-P.;
RT "Adaptive diversification of bitter taste receptor genes in mammalian
RT evolution.";
RL Mol. Biol. Evol. 20:805-814(2003).
CC -!- FUNCTION: Putative taste receptor which may play a role in the
CC perception of bitterness. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000255}.
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DR EMBL; AC129318; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK001075; DAA01214.1; -; Genomic_DNA.
DR CCDS; CCDS20613.1; -.
DR RefSeq; NP_996902.1; NM_207019.1.
DR AlphaFoldDB; Q7M722; -.
DR SMR; Q7M722; -.
DR STRING; 10090.ENSMUSP00000079453; -.
DR GlyGen; Q7M722; 1 site.
DR iPTMnet; Q7M722; -.
DR PhosphoSitePlus; Q7M722; -.
DR PaxDb; Q7M722; -.
DR PRIDE; Q7M722; -.
DR DNASU; 387346; -.
DR Ensembl; ENSMUST00000080619; ENSMUSP00000079453; ENSMUSG00000063478.
DR GeneID; 387346; -.
DR KEGG; mmu:387346; -.
DR UCSC; uc009eja.1; mouse.
DR CTD; 387346; -.
DR MGI; MGI:2681218; Tas2r114.
DR VEuPathDB; HostDB:ENSMUSG00000063478; -.
DR eggNOG; ENOG502T3AX; Eukaryota.
DR GeneTree; ENSGT00960000186648; -.
DR HOGENOM; CLU_072337_3_0_1; -.
DR InParanoid; Q7M722; -.
DR OMA; WLFTFPQ; -.
DR OrthoDB; 1010573at2759; -.
DR PhylomeDB; Q7M722; -.
DR TreeFam; TF335891; -.
DR BioGRID-ORCS; 387346; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q7M722; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q7M722; protein.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0033038; F:bitter taste receptor activity; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..309
FT /note="Taste receptor type 2 member 114"
FT /id="PRO_0000248473"
FT TOPO_DOM 1..7
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..43
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..87
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..127
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..182
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..259
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 161
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 309 AA; 35732 MW; D6456A379D5EEE64 CRC64;
MLSTMEGVLL SVSTSEAVLG IVGNTFIALV NCMDYNRNKK LSNIGFILTG LAISRICLVL
ILITEAYIKI FYPQLLSPVN IIELISYLWI IICQLNVWFA TSLSIFYFLK IANFSHYIFV
WLKRRIDLVF FFLIGCLLIS WLFSFPVVAK MVKDNKMLYI NTSWQIHMKK SELIINYVFT
NGGVFLFFMI MLIVCFLLII SLWRHRRQME SNKLGFRDLN TEVHVRTIKV LLSFIILFIL
HFMGITINVI CLLIPESNLL FMFGLTTAFI YPGCHSLILI LANSRLKQCS VMILQLLKCC
ENGKELRDT
