ID   TR114_RAT               Reviewed;         309 AA.
AC   Q9JKT8;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Taste receptor type 2 member 114;
DE            Short=T2R114;
DE   AltName: Full=Taste receptor type 2 member 5;
DE            Short=T2R5;
GN   Name=Tas2r114 {ECO:0000250|UniProtKB:Q7M722};
GN   Synonyms=Tas2r5 {ECO:0000312|RGD:620737};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:AAF43916.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10761934; DOI=10.1016/s0092-8674(00)80705-9;
RA   Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P.,
RA   Zuker C.S.;
RT   "A novel family of mammalian taste receptors.";
RL   Cell 100:693-702(2000).
CC   -!- FUNCTION: Putative taste receptor which may play a role in the
CC       perception of bitterness. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC       taste receptor cell. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000255}.
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DR   EMBL; AF227143; AAF43916.1; -; mRNA.
DR   RefSeq; NP_076486.1; NM_023996.1.
DR   AlphaFoldDB; Q9JKT8; -.
DR   SMR; Q9JKT8; -.
DR   STRING; 10116.ENSRNOP00000007497; -.
DR   GlyGen; Q9JKT8; 1 site.
DR   PaxDb; Q9JKT8; -.
DR   GeneID; 78982; -.
DR   KEGG; rno:78982; -.
DR   UCSC; RGD:620737; rat.
DR   CTD; 387346; -.
DR   RGD; 620737; Tas2r114.
DR   eggNOG; ENOG502T3AX; Eukaryota.
DR   InParanoid; Q9JKT8; -.
DR   OrthoDB; 1010573at2759; -.
DR   PhylomeDB; Q9JKT8; -.
DR   PRO; PR:Q9JKT8; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008527; F:taste receptor activity; TAS:UniProtKB.
DR   GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR   InterPro; IPR007960; TAS2R.
DR   Pfam; PF05296; TAS2R; 1.
PE   2: Evidence at transcript level;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..309
FT                   /note="Taste receptor type 2 member 114"
FT                   /id="PRO_0000248474"
FT   TOPO_DOM        1..7
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        8..28
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        29..43
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        65..87
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        109..127
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..148
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        149..182
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        204..233
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        255..259
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        281..309
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        161
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   309 AA;  35604 MW;  E22D073D19B687F4 CRC64;
     MLGAMEGVLL SVATSEALLG IVGNTFIALV NCMDCTRNKN LYNIGFILTG LAISRICLVW
     ILITEAYIKI FSPQLLSPIN IIELISYLWI ITSQLNVWFA TSLSIFYFLK IANFSHHIFL
     WLKRRINIVF AFLIGCLLMS WLFSFPVVVK MVKDKKMLYI NSSWQIHMKK SELIINYVFT
     NGGVFLLFII MLIVCFLLII SLWRHSKWMQ SNESGFRDLN TEVHVKTIKV LLSFIILFIL
     HLIGITINVI CLLVPENNLL FVFGLTIAFL YPCCHSLILI LANSRLKRCF VRILQQLMCS
     EEGKEFRNT