ID   TR116_RAT               Reviewed;         324 AA.
AC   Q67ER8;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Taste receptor type 2 member 116;
DE            Short=T2R116;
DE   AltName: Full=Taste receptor type 2 member 33;
DE            Short=T2R33;
GN   Name=Tas2r116 {ECO:0000250|UniProtKB:Q7M713}; Synonyms=T2r33;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:AAR13361.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAR13361.1};
RA   Conte C., Ebeling M., Marcuz A., Andres-Barquin P.J.;
RT   "Identification of new putative rat taste receptors belonging to the T2R
RT   family.";
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative taste receptor which may play a role in the
CC       perception of bitterness. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC       taste receptor cell. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000255}.
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DR   EMBL; AY362752; AAR13361.1; -; Genomic_DNA.
DR   RefSeq; NP_001160151.1; NM_001166679.1.
DR   AlphaFoldDB; Q67ER8; -.
DR   SMR; Q67ER8; -.
DR   STRING; 10116.ENSRNOP00000036964; -.
DR   GlyGen; Q67ER8; 1 site.
DR   PaxDb; Q67ER8; -.
DR   Ensembl; ENSRNOT00000028970; ENSRNOP00000036964; ENSRNOG00000021366.
DR   GeneID; 100310877; -.
DR   KEGG; rno:100310877; -.
DR   UCSC; RGD:2314261; rat.
DR   CTD; 112408; -.
DR   RGD; 2314261; Tas2r116.
DR   eggNOG; ENOG502SKRK; Eukaryota.
DR   GeneTree; ENSGT00960000186648; -.
DR   HOGENOM; CLU_072337_3_0_1; -.
DR   InParanoid; Q67ER8; -.
DR   OMA; WLRCRHK; -.
DR   OrthoDB; 1010573at2759; -.
DR   PhylomeDB; Q67ER8; -.
DR   TreeFam; TF335891; -.
DR   PRO; PR:Q67ER8; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0033038; F:bitter taste receptor activity; ISO:RGD.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008527; F:taste receptor activity; ISO:RGD.
DR   GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:RGD.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR007960; TAS2R.
DR   Pfam; PF05296; TAS2R; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..324
FT                   /note="Taste receptor type 2 member 116"
FT                   /id="PRO_0000248476"
FT   TOPO_DOM        1..2
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        3..23
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        24..55
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        77..94
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        116..128
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        150..183
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        184..204
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        205..236
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        258..261
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..282
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        283..324
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        162
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   324 AA;  37020 MW;  3A80C0FDDCF18CEA CRC64;
     MNGVLYITFT VILSVEVIIG NFGNGIIALV NIMDLAKRRK ISSVDQILTA LAISRIVLLW
     LVLVSWWLSM FYPGQWMTEG IDVIVHNVWT TLNQISLWLA TSFSVFCFLK VANFSNTIFF
     YLKIRVKKVM TGTLIMFLLL LGLNIIVINA SKTILIPEYK VNMSNSLNLK NTQISMLFPF
     ANTLFGFIPF AVSLVTFLLL FFSLWKHQRK MHHGAQGCRD SSTKAHIRVL QTLIASILLY
     FVFFLSLVVK VWISLFLERM LLLLITQAAK IAFPSLHPWV LILGNAKLRK ASLSALQWLR
     CRHKDEHRRV QRPEVHSCGS SCMP