TR117_MOUSE
ID TR117_MOUSE Reviewed; 330 AA.
AC Q7M715; A2RSQ6;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Taste receptor type 2 member 117;
DE Short=T2R117;
DE Short=mT2R54;
GN Name=Tas2r117 {ECO:0000312|MGI:MGI:2681242};
GN Synonyms=T2r54 {ECO:0000303|PubMed:12679530};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3] {ECO:0000305, ECO:0000312|EMBL:DAA01221.1}
RP IDENTIFICATION.
RX PubMed=12679530; DOI=10.1093/molbev/msg083;
RA Shi P., Zhang J., Yang H., Zhang Y.-P.;
RT "Adaptive diversification of bitter taste receptor genes in mammalian
RT evolution.";
RL Mol. Biol. Evol. 20:805-814(2003).
CC -!- FUNCTION: Putative taste receptor which may play a role in the
CC perception of bitterness. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000255}.
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DR EMBL; AC129318; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC132206; AAI32207.1; -; mRNA.
DR EMBL; BC132208; AAI32209.1; -; mRNA.
DR EMBL; BK001082; DAA01221.1; -; Genomic_DNA.
DR CCDS; CCDS20623.1; -.
DR RefSeq; NP_996904.1; NM_207021.1.
DR AlphaFoldDB; Q7M715; -.
DR SMR; Q7M715; -.
DR GlyGen; Q7M715; 2 sites.
DR PaxDb; Q7M715; -.
DR PRIDE; Q7M715; -.
DR Ensembl; ENSMUST00000068302; ENSMUSP00000069768; ENSMUSG00000058349.
DR GeneID; 353166; -.
DR KEGG; mmu:353166; -.
DR UCSC; uc009ejp.1; mouse.
DR CTD; 353166; -.
DR MGI; MGI:2681242; Tas2r117.
DR VEuPathDB; HostDB:ENSMUSG00000058349; -.
DR eggNOG; ENOG502SKRK; Eukaryota.
DR GeneTree; ENSGT00960000186648; -.
DR HOGENOM; CLU_072337_3_0_1; -.
DR InParanoid; Q7M715; -.
DR OMA; INICINE; -.
DR OrthoDB; 1010573at2759; -.
DR PhylomeDB; Q7M715; -.
DR TreeFam; TF335891; -.
DR BioGRID-ORCS; 353166; 3 hits in 70 CRISPR screens.
DR PRO; PR:Q7M715; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q7M715; protein.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0033038; F:bitter taste receptor activity; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0008527; F:taste receptor activity; ISO:MGI.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..330
FT /note="Taste receptor type 2 member 117"
FT /id="PRO_0000248477"
FT TOPO_DOM 1..16
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..37
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..53
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 54..74
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 75..95
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..116
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 117..135
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..190
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..330
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 76
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 169
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 330 AA; 38528 MW; FEE10C0E572D4C87 CRC64;
MKHFWKILSV ISQSTLSVIL IVELVIGIIG NGFMVLVHCM DWVKKKKMSL VNQILTALSI
SRIFQLCLLF ISLVINFSYT DLTTSSRMIQ VMYNAWILAN HFSIWIATCL TVLYFLKIAN
FSNSFFLYLK WRVEKVVSVT LLVSLLLLIL NILLTNLETD MWTNEYQRNI SCSFSSHYYA
KCHRQVLRLH IIFLSVPVVL SLSTFLLLIF SLWTHHKRMQ QHVQGGRDAR TTAHFKALQT
VIAFFLLYSI FILSVLIQIW KYELLKKNLF VVFCEVVYIA FPTFHSYILI VGDMKLRQAC
LPLCIIAAEI QTTLCRNFRS LKYFRLCCIF
