TR119_MOUSE
ID TR119_MOUSE Reviewed; 335 AA.
AC Q9JKT2; Q2M2Q7;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=Taste receptor type 2 member 119;
DE Short=T2R119;
DE AltName: Full=Taste receptor type 2 member 19;
DE Short=T2R19;
GN Name=Tas2r119; Synonyms=Tas2r19;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ;
RX PubMed=10761934; DOI=10.1016/s0092-8674(00)80705-9;
RA Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P.,
RA Zuker C.S.;
RT "A novel family of mammalian taste receptors.";
RL Cell 100:693-702(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-335.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP CHARACTERIZATION.
RX PubMed=10761935; DOI=10.1016/s0092-8674(00)80706-0;
RA Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W.,
RA Zuker C.S., Ryba N.J.P.;
RT "T2Rs function as bitter taste receptors.";
RL Cell 100:703-711(2000).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=11854532; DOI=10.1073/pnas.042617699;
RA Wu S.V., Rozengurt N., Yang M., Young S.H., Sinnett-Smith J., Rozengurt E.;
RT "Expression of bitter taste receptors of the T2R family in the
RT gastrointestinal tract and enteroendocrine STC-1 cells.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:2392-2397(2002).
RN [5]
RP REVIEW.
RX PubMed=12139982; DOI=10.1016/s0959-4388(02)00345-8;
RA Montmayeur J.-P., Matsunami H.;
RT "Receptors for bitter and sweet taste.";
RL Curr. Opin. Neurobiol. 12:366-371(2002).
RN [6]
RP REVIEW.
RX PubMed=11696554; DOI=10.1074/jbc.r100054200;
RA Margolskee R.F.;
RT "Molecular mechanisms of bitter and sweet taste transduction.";
RL J. Biol. Chem. 277:1-4(2002).
RN [7]
RP REVIEW.
RX PubMed=12581520; DOI=10.1016/s0092-8674(03)00071-0;
RA Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D.,
RA Zuker C.S., Ryba N.J.;
RT "Coding of sweet, bitter, and umami tastes: different receptor cells
RT sharing similar signaling pathways.";
RL Cell 112:293-301(2003).
CC -!- FUNCTION: Gustducin-coupled receptor implicated in the perception of
CC bitter compounds in the oral cavity and the gastrointestinal tract.
CC Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the
CC tongue and palate epithelium and exclusively in gustducin-positive
CC cells. Expressed in 15% taste bud cells in circumvallate and foliate
CC papillae but only in 2% in fungiform papillae. Expressed in the gastro
CC and duodenal tissue. Not expressed in colon, liver, heart and kidney.
CC {ECO:0000269|PubMed:11854532}.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
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DR EMBL; AF227149; AAF43922.1; -; Genomic_DNA.
DR EMBL; BC111811; AAI11812.1; -; mRNA.
DR RefSeq; NP_065249.2; NM_020503.2.
DR AlphaFoldDB; Q9JKT2; -.
DR SMR; Q9JKT2; -.
DR STRING; 10090.ENSMUSP00000050277; -.
DR GlyGen; Q9JKT2; 2 sites.
DR PhosphoSitePlus; Q9JKT2; -.
DR PaxDb; Q9JKT2; -.
DR PRIDE; Q9JKT2; -.
DR DNASU; 57254; -.
DR GeneID; 57254; -.
DR KEGG; mmu:57254; -.
DR CTD; 57254; -.
DR MGI; MGI:2681253; Tas2r119.
DR eggNOG; ENOG502S2SI; Eukaryota.
DR InParanoid; Q9JKT2; -.
DR OrthoDB; 1010573at2759; -.
DR PhylomeDB; Q9JKT2; -.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR Reactome; R-MMU-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Reactome; R-MMU-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR BioGRID-ORCS; 57254; 4 hits in 71 CRISPR screens.
DR PRO; PR:Q9JKT2; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q9JKT2; protein.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0033038; F:bitter taste receptor activity; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0008527; F:taste receptor activity; TAS:UniProtKB.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
PE 1: Evidence at protein level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..335
FT /note="Taste receptor type 2 member 119"
FT /id="PRO_0000082192"
FT TOPO_DOM 1..7
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..43
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..81
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..124
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146..176
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 198..224
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 246..256
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 278..335
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 81
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 163
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 160
FT /note="F -> S (in Ref. 2; AAI11812)"
FT /evidence="ECO:0000305"
FT CONFLICT 288
FT /note="T -> M (in Ref. 2; AAI11812)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 335 AA; 37735 MW; 1399C323FC7CE645 CRC64;
MMEGHMLFFL LVVVVQFLTG VLANGLIVVV NAIDLIMWKK MAPLDLLLFC LATSRIILQL
CILFAQLGLS CLVRHTLFAD NVTFVYIINE LSLWFATWLG VFYCAKIATI PHPLFLWLKM
RISRLVPWLI LASVVYVTVT TFIHSRETSE LPKQIFISFF SKNTTRVRPA HATLLSVFVF
GLTLPFLIFT VAVLLLLSSL WNHSRQMRTM VGTREPSRHA LVSAMLSILS FLILYLSHDM
VAVLICTQGL HFGSRTFAFC LLVIGMYPSL HSIVLILGNP KLKRNAKTFI VHCKCCHCAR
AWVTSRNPRL SDLPVPATHH SANKTSCSEA CIMPS
