TR120_MOUSE
ID TR120_MOUSE Reviewed; 295 AA.
AC Q7M721;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Taste receptor type 2 member 120;
DE Short=T2R120;
DE Short=mT2R47;
GN Name=Tas2r120 {ECO:0000312|MGI:MGI:2681256};
GN Synonyms=T2r47 {ECO:0000303|PubMed:12679530};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000305}
RP PROTEIN SEQUENCE OF 282-294, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
RN [3] {ECO:0000305, ECO:0000312|EMBL:DAA01215.1}
RP IDENTIFICATION.
RX PubMed=12679530; DOI=10.1093/molbev/msg083;
RA Shi P., Zhang J., Yang H., Zhang Y.-P.;
RT "Adaptive diversification of bitter taste receptor genes in mammalian
RT evolution.";
RL Mol. Biol. Evol. 20:805-814(2003).
CC -!- FUNCTION: Putative taste receptor which may play a role in the
CC perception of bitterness. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000255}.
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DR EMBL; AC129318; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK001076; DAA01215.1; -; Genomic_DNA.
DR CCDS; CCDS20617.1; -.
DR RefSeq; NP_996906.1; NM_207023.1.
DR AlphaFoldDB; Q7M721; -.
DR SMR; Q7M721; -.
DR STRING; 10090.ENSMUSP00000071626; -.
DR GlyGen; Q7M721; 1 site.
DR iPTMnet; Q7M721; -.
DR PhosphoSitePlus; Q7M721; -.
DR PaxDb; Q7M721; -.
DR PRIDE; Q7M721; -.
DR DNASU; 387348; -.
DR Ensembl; ENSMUST00000071707; ENSMUSP00000071626; ENSMUSG00000059382.
DR GeneID; 387348; -.
DR KEGG; mmu:387348; -.
DR UCSC; uc009eji.1; mouse.
DR CTD; 387348; -.
DR MGI; MGI:2681256; Tas2r120.
DR VEuPathDB; HostDB:ENSMUSG00000059382; -.
DR eggNOG; ENOG502TE6U; Eukaryota.
DR GeneTree; ENSGT00960000186648; -.
DR HOGENOM; CLU_072337_2_0_1; -.
DR InParanoid; Q7M721; -.
DR OMA; FCQAIIF; -.
DR OrthoDB; 1339037at2759; -.
DR PhylomeDB; Q7M721; -.
DR TreeFam; TF335891; -.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR Reactome; R-MMU-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Reactome; R-MMU-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR BioGRID-ORCS; 387348; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q7M721; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q7M721; protein.
DR GO; GO:0016021; C:integral component of membrane; ISO:MGI.
DR GO; GO:0031514; C:motile cilium; ISO:MGI.
DR GO; GO:0033038; F:bitter taste receptor activity; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0008527; F:taste receptor activity; ISO:MGI.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Sensory transduction; Taste;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..295
FT /note="Taste receptor type 2 member 120"
FT /id="PRO_0000248479"
FT TOPO_DOM 1..5
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 6..26
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 27..45
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..80
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..127
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..177
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 199..228
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..249
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 250..255
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 256..276
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 277..295
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 160
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 295 AA; 33594 MW; 8E2D6847B7AA4431 CRC64;
MNLVEWIVTI IMMTEFLLGN CANVFITIVN FIDCVKRRKI SSADRIITAI AIFRIGLLWA
MLTNWHSHVF TPDTDNLQMR VFGGITWAIT NHFTTWLGTI LSMFYLFKIA NFSNSLFLHL
KRKLDNVLLV IFLGSSLFLV AYLGMVNIKK IAWMSIHEGN VTTKSKLKHV TSITNMLLFS
LINIVPFGIS LNCVLLLIYS LSKHLKNMKF YGKGCQDQST MVHIKALQTV VSFLLLYATY
SSCVIISGWS LQNAPVFLFC VTIGSFYPAG HSCILIWGNQ KLKQVFLLLL RQMRC
