ID   TR120_RAT               Reviewed;         295 AA.
AC   Q67ET3;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Taste receptor type 2 member 120;
DE            Short=T2R120;
DE   AltName: Full=Taste receptor type 2 member 17;
DE            Short=T2R17;
GN   Name=Tas2r120 {ECO:0000250|UniProtKB:Q7M721}; Synonyms=T2r17;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:AAR13346.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAR13346.1};
RA   Conte C., Ebeling M., Marcuz A., Andres-Barquin P.J.;
RT   "Identification of new putative rat taste receptors belonging to the T2R
RT   family.";
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative taste receptor which may play a role in the
CC       perception of bitterness. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC       taste receptor cell. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000255}.
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DR   EMBL; AY362737; AAR13346.1; -; Genomic_DNA.
DR   RefSeq; NP_001074406.1; NM_001080937.1.
DR   AlphaFoldDB; Q67ET3; -.
DR   SMR; Q67ET3; -.
DR   STRING; 10116.ENSRNOP00000032084; -.
DR   GlyGen; Q67ET3; 1 site.
DR   PaxDb; Q67ET3; -.
DR   Ensembl; ENSRNOT00000031438; ENSRNOP00000032084; ENSRNOG00000021445.
DR   GeneID; 690448; -.
DR   KEGG; rno:690448; -.
DR   UCSC; RGD:1596060; rat.
DR   CTD; 387348; -.
DR   RGD; 1596060; Tas2r120.
DR   eggNOG; ENOG502TE6U; Eukaryota.
DR   GeneTree; ENSGT00960000186648; -.
DR   HOGENOM; CLU_072337_2_0_1; -.
DR   InParanoid; Q67ET3; -.
DR   OMA; FCQAIIF; -.
DR   OrthoDB; 1339037at2759; -.
DR   PhylomeDB; Q67ET3; -.
DR   TreeFam; TF335891; -.
DR   Reactome; R-RNO-418594; G alpha (i) signalling events.
DR   Reactome; R-RNO-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR   Reactome; R-RNO-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR   PRO; PR:Q67ET3; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000021445; Expressed in heart.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0033038; F:bitter taste receptor activity; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR   InterPro; IPR007960; TAS2R.
DR   Pfam; PF05296; TAS2R; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..295
FT                   /note="Taste receptor type 2 member 120"
FT                   /id="PRO_0000248480"
FT   TOPO_DOM        1..5
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        6..26
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        27..45
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        67..83
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        105..125
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        147..177
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        199..230
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        231..251
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        252..255
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..276
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        277..295
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        160
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   295 AA;  33578 MW;  3E69B4F6A88141C4 CRC64;
     MDLTEWIVTI IMMIEFLLGN CANFFIMVVN AIDCMKRRKI SSADRIITAL AISRIGLLWA
     MLMNWHSRVY TTDTYSFQVT AFSGIIWAIT NHFTTWLGTI LSMFYLFKIA NFSNCLFLHL
     KRKLDSVLLV IFLVSSLLVF AYLGVVNIKK IAWLSVHEGN VTVKSKLMNI ASIRDTLLFS
     LINIAPFGIS LTCVLLLIYS LGKHLKNMKF YGKGCQDQST MVHIRALQTV VSFLLLYATY
     SSCVIISGWS IQNVPIFLFC VTIGAFYPAG HSCILIWGNQ KLKQFLLLFL RQMKC