TR123_MOUSE
ID TR123_MOUSE Reviewed; 333 AA.
AC P59528; Q7M714;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Taste receptor type 2 member 123;
DE Short=T2R123;
DE AltName: Full=STC9-2;
DE AltName: Full=Taste receptor type 2 member 23;
DE Short=T2R23;
DE Short=mT2R55;
GN Name=Tas2r123; Synonyms=T2r55, Tas2r23;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX PubMed=11854532; DOI=10.1073/pnas.042617699;
RA Wu S.V., Rozengurt N., Yang M., Young S.H., Sinnett-Smith J., Rozengurt E.;
RT "Expression of bitter taste receptors of the T2R family in the
RT gastrointestinal tract and enteroendocrine STC-1 cells.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:2392-2397(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Zuker C.S., Adler J.E., Ryba N., Mueller K., Hoon M.;
RT "T2r taste receptor family.";
RL Patent number WO0118050, 15-MAR-2001.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP IDENTIFICATION.
RX PubMed=12679530; DOI=10.1093/molbev/msg083;
RA Shi P., Zhang J., Yang H., Zhang Y.-P.;
RT "Adaptive diversification of bitter taste receptor genes in mammalian
RT evolution.";
RL Mol. Biol. Evol. 20:805-814(2003).
RN [5]
RP REVIEW.
RX PubMed=12139982; DOI=10.1016/s0959-4388(02)00345-8;
RA Montmayeur J.-P., Matsunami H.;
RT "Receptors for bitter and sweet taste.";
RL Curr. Opin. Neurobiol. 12:366-371(2002).
RN [6]
RP REVIEW.
RX PubMed=11696554; DOI=10.1074/jbc.r100054200;
RA Margolskee R.F.;
RT "Molecular mechanisms of bitter and sweet taste transduction.";
RL J. Biol. Chem. 277:1-4(2002).
RN [7]
RP REVIEW.
RX PubMed=12581520; DOI=10.1016/s0092-8674(03)00071-0;
RA Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D.,
RA Zuker C.S., Ryba N.J.;
RT "Coding of sweet, bitter, and umami tastes: different receptor cells
RT sharing similar signaling pathways.";
RL Cell 112:293-301(2003).
CC -!- FUNCTION: Gustducin-coupled receptor implicated in the perception of
CC bitter compounds in the oral cavity and the gastrointestinal tract.
CC Signals through PLCB2 and the calcium-regulated cation channel TRPM5
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the
CC tongue and palate epithelium and exclusively in gustducin-positive
CC cells. Expressed in the duodenum, antrum and fundus (part of the
CC stomach). {ECO:0000269|PubMed:11854532}.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
CC -!- CAUTION: This protein was previously referred to as T2R2 but is now
CC considered to be an ortholog of rat TAS2R23. {ECO:0000305}.
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DR EMBL; AF412305; AAL85202.1; -; Genomic_DNA.
DR EMBL; AX097844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC129318; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK001083; DAA01222.1; -; Genomic_DNA.
DR CCDS; CCDS20624.1; -.
DR RefSeq; NP_996908.1; NM_207025.1.
DR AlphaFoldDB; P59528; -.
DR SMR; P59528; -.
DR GlyGen; P59528; 4 sites.
DR iPTMnet; P59528; -.
DR PaxDb; P59528; -.
DR PRIDE; P59528; -.
DR DNASU; 353167; -.
DR Ensembl; ENSMUST00000071696; ENSMUSP00000071615; ENSMUSG00000057381.
DR GeneID; 353167; -.
DR KEGG; mmu:353167; -.
DR UCSC; uc009ejq.1; mouse.
DR CTD; 353167; -.
DR MGI; MGI:2681264; Tas2r123.
DR VEuPathDB; HostDB:ENSMUSG00000057381; -.
DR eggNOG; ENOG502SKRK; Eukaryota.
DR GeneTree; ENSGT00960000186648; -.
DR HOGENOM; CLU_072337_3_0_1; -.
DR InParanoid; P59528; -.
DR OMA; NTRIDAW; -.
DR OrthoDB; 1053374at2759; -.
DR PhylomeDB; P59528; -.
DR TreeFam; TF335891; -.
DR BioGRID-ORCS; 353167; 0 hits in 71 CRISPR screens.
DR PRO; PR:P59528; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P59528; protein.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0033038; F:bitter taste receptor activity; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0008527; F:taste receptor activity; ISO:MGI.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..333
FT /note="Taste receptor type 2 member 123"
FT /id="PRO_0000082194"
FT TOPO_DOM 1..13
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 14..34
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 35..60
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..90
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..134
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..205
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..253
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 275..281
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..302
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 303..333
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 167
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 186
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 195
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 5
FT /note="K -> E (in Ref. 1; AAL85202)"
FT /evidence="ECO:0000305"
FT CONFLICT 8
FT /note="Y -> C (in Ref. 1; AAL85202)"
FT /evidence="ECO:0000305"
FT CONFLICT 42
FT /note="K -> G (in Ref. 1; AAL85202)"
FT /evidence="ECO:0000305"
FT CONFLICT 65..66
FT /note="LS -> WA (in Ref. 1; AAL85202)"
FT /evidence="ECO:0000305"
FT CONFLICT 77
FT /note="C -> S (in Ref. 1; AAL85202)"
FT /evidence="ECO:0000305"
FT CONFLICT 207
FT /note="F -> V (in Ref. 1; AAL85202)"
FT /evidence="ECO:0000305"
FT CONFLICT 238
FT /note="K -> S (in Ref. 1; AAL85202)"
FT /evidence="ECO:0000305"
FT CONFLICT 242
FT /note="D -> N (in Ref. 1; AAL85202)"
FT /evidence="ECO:0000305"
FT CONFLICT 265
FT /note="Y -> N (in Ref. 1; AAL85202)"
FT /evidence="ECO:0000305"
FT CONFLICT 292
FT /note="G -> A (in Ref. 1; AAL85202)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 333 AA; 38032 MW; C6184E9D5F153198 CRC64;
MFSQKINYSH LFTFSITLYV EIVTGILGHG FIALVNIMDW VKRRRISSVD QILTALALTR
FIYVLSMLIC ILLFMLCPHL PRRSEMLSAM GIFWVVNSHF SIWLTTCLGV FYFLKIANFS
NSFFLYLKWR VKKVILIIIL ASLIFLTLHI LSLGIYDQFS IAAYVGNMSY SLTDLTQFSS
TFLFSNSSNV FLITNSSHVF LPINSLFMLI PFTVSLVAFL MLIFSLWKHH KKMQVNAKQP
RDVSTMAHIK ALQTVFSFLL LYAIYLLFLI IGILNLGLME KIVILIFDHI SGAVFPISHS
FVLILGNSKL RQASLSVLPC LRCQSKDMDT MGL
