TR123_RAT
ID TR123_RAT Reviewed; 333 AA.
AC Q9JKF0;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Taste receptor type 2 member 123;
DE Short=T2R123;
DE AltName: Full=Taste receptor type 2 member 2;
DE Short=T2R2;
DE AltName: Full=Taste receptor type 2 member 23;
DE Short=T2R23;
GN Name=Tas2r123; Synonyms=Tas2r14, Tas2r2, Tas2r23;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TOPOLOGY.
RX PubMed=10761934; DOI=10.1016/s0092-8674(00)80705-9;
RA Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P.,
RA Zuker C.S.;
RT "A novel family of mammalian taste receptors.";
RL Cell 100:693-702(2000).
RN [2]
RP CHARACTERIZATION.
RX PubMed=10761935; DOI=10.1016/s0092-8674(00)80706-0;
RA Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W.,
RA Zuker C.S., Ryba N.J.P.;
RT "T2Rs function as bitter taste receptors.";
RL Cell 100:703-711(2000).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=11854532; DOI=10.1073/pnas.042617699;
RA Wu S.V., Rozengurt N., Yang M., Young S.H., Sinnett-Smith J., Rozengurt E.;
RT "Expression of bitter taste receptors of the T2R family in the
RT gastrointestinal tract and enteroendocrine STC-1 cells.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:2392-2397(2002).
RN [4]
RP REVIEW.
RX PubMed=12139982; DOI=10.1016/s0959-4388(02)00345-8;
RA Montmayeur J.-P., Matsunami H.;
RT "Receptors for bitter and sweet taste.";
RL Curr. Opin. Neurobiol. 12:366-371(2002).
RN [5]
RP REVIEW.
RX PubMed=11696554; DOI=10.1074/jbc.r100054200;
RA Margolskee R.F.;
RT "Molecular mechanisms of bitter and sweet taste transduction.";
RL J. Biol. Chem. 277:1-4(2002).
RN [6]
RP REVIEW.
RX PubMed=12581520; DOI=10.1016/s0092-8674(03)00071-0;
RA Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D.,
RA Zuker C.S., Ryba N.J.;
RT "Coding of sweet, bitter, and umami tastes: different receptor cells
RT sharing similar signaling pathways.";
RL Cell 112:293-301(2003).
CC -!- FUNCTION: Gustducin-coupled receptor implicated in the perception of
CC bitter compounds in the oral cavity and the gastrointestinal tract.
CC Signals through PLCB2 and the calcium-regulated cation channel TRPM5.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the
CC tongue and palate epithelium and exclusively in gustducin-positive
CC cells. Expressed in the antrum and fundus (part of the stomach),
CC duodenum and in gastric endocrine cells. {ECO:0000269|PubMed:11854532}.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
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DR EMBL; AF240765; AAF45303.1; -; mRNA.
DR RefSeq; NP_775458.1; NM_173336.1.
DR AlphaFoldDB; Q9JKF0; -.
DR STRING; 10116.ENSRNOP00000041021; -.
DR GlyGen; Q9JKF0; 3 sites.
DR PaxDb; Q9JKF0; -.
DR GeneID; 287003; -.
DR KEGG; rno:287003; -.
DR UCSC; RGD:727880; rat.
DR CTD; 353167; -.
DR RGD; 727880; Tas2r123.
DR eggNOG; ENOG502SKRK; Eukaryota.
DR InParanoid; Q9JKF0; -.
DR OrthoDB; 1053374at2759; -.
DR PhylomeDB; Q9JKF0; -.
DR PRO; PR:Q9JKF0; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0033038; F:bitter taste receptor activity; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0008527; F:taste receptor activity; TAS:UniProtKB.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
PE 1: Evidence at protein level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..333
FT /note="Taste receptor type 2 member 123"
FT /id="PRO_0000082195"
FT TOPO_DOM 1..14
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 15..37
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..77
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..91
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..114
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..133
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..204
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..227
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 228..250
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 251..273
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 274..282
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..305
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 306..333
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 167
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 186
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 195
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 333 AA; 38164 MW; AD58EC247B9E610E CRC64;
MFSQKTNYSH LFTFSIIFYV EIVTGILGNG FIALVNIMDW LKRRRISTAD QILTALALTR
LIYVWSVLIC ILLLFLCPHL SMRPEMFTAI GVIWVVDNHF SIWLATCLGV FYFLKIASFS
NSLFLYLKWR VKKVVLMIIL ISLIFLMLNI SSLGMYDHFS IDVYEGNMSY NLVDSTHFPR
IFLFTNSSKV FLIANSSHVF LPINSLFMLI PFTVSLVAFF VLFLSLWKHH KKMQVNAKGP
RDASTMAHTK ALQIGFSFLL LYAIYLLFII TGILNLDLMR CIVILLFDHI SGAVFSISHS
FVLILGNSKL RQATLSVLPC LRCRSKDMDT VVF
