TR124_MOUSE
ID TR124_MOUSE Reviewed; 309 AA.
AC Q7M718;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Taste receptor type 2 member 124;
DE Short=T2R124;
DE Short=mT2R50;
GN Name=Tas2r124 {ECO:0000312|MGI:MGI:2681267};
GN Synonyms=T2r50 {ECO:0000303|PubMed:12679530};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000305, ECO:0000312|EMBL:DAA01218.1}
RP IDENTIFICATION.
RX PubMed=12679530; DOI=10.1093/molbev/msg083;
RA Shi P., Zhang J., Yang H., Zhang Y.-P.;
RT "Adaptive diversification of bitter taste receptor genes in mammalian
RT evolution.";
RL Mol. Biol. Evol. 20:805-814(2003).
CC -!- FUNCTION: Putative taste receptor which may play a role in the
CC perception of bitterness. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000255}.
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DR EMBL; AC152822; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK001079; DAA01218.1; -; Genomic_DNA.
DR CCDS; CCDS20620.1; -.
DR RefSeq; NP_996909.1; NM_207026.1.
DR AlphaFoldDB; Q7M718; -.
DR SMR; Q7M718; -.
DR STRING; 10090.ENSMUSP00000075509; -.
DR GlyGen; Q7M718; 3 sites.
DR iPTMnet; Q7M718; -.
DR PhosphoSitePlus; Q7M718; -.
DR PaxDb; Q7M718; -.
DR PeptideAtlas; Q7M718; -.
DR PRIDE; Q7M718; -.
DR DNASU; 387351; -.
DR Ensembl; ENSMUST00000076150; ENSMUSP00000075509; ENSMUSG00000060412.
DR GeneID; 387351; -.
DR KEGG; mmu:387351; -.
DR UCSC; uc009ejm.1; mouse.
DR CTD; 387351; -.
DR MGI; MGI:2681267; Tas2r124.
DR VEuPathDB; HostDB:ENSMUSG00000060412; -.
DR eggNOG; ENOG502TE6X; Eukaryota.
DR GeneTree; ENSGT00960000186648; -.
DR HOGENOM; CLU_072337_2_0_1; -.
DR InParanoid; Q7M718; -.
DR OMA; ELVHIIC; -.
DR OrthoDB; 1123629at2759; -.
DR PhylomeDB; Q7M718; -.
DR TreeFam; TF335891; -.
DR BioGRID-ORCS; 387351; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q7M718; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q7M718; protein.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0033038; F:bitter taste receptor activity; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI.
DR GO; GO:0032467; P:positive regulation of cytokinesis; ISO:MGI.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..309
FT /note="Taste receptor type 2 member 124"
FT /id="PRO_0000248481"
FT TOPO_DOM 1..7
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..86
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 108..127
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..183
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 205..230
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 231..251
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 252..261
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 283..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 160
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 180
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 255
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 309 AA; 35966 MW; 85020A439FC41AC2 CRC64;
MVPVLHSLST IILIAEFVWG NLSNGLIVLK NCIDWINKKE LSTVDQILIV LAISRISLIW
ETLIIWVKDQ LISSITIEEL KIIVFSFILS SHFSLWLATA LSIFYLFRIP NCYWQIFLYL
KWRIKQLIVH MLLGSLVFLV ANMIQITITL EERFYQYGGN TSVNSMETEF SILIELMLFN
MTMFSIIPFS LALISFLLLI FSLWKHLQKM PLNSRGDRDP SATAHRNALR ILVSFLLLYT
IYFLSLLISW VAQKNQSELV HIICMITSLV YPSFHSYILI LGNYKLKQTS LWVMRQLGCR
MKRQNTPTT
