TR124_RAT
ID TR124_RAT Reviewed; 309 AA.
AC Q67ES5;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Taste receptor type 2 member 124;
DE Short=T2R124;
DE AltName: Full=Taste receptor type 2 member 25;
DE Short=T2R25;
GN Name=Tas2r124 {ECO:0000250|UniProtKB:Q7M718}; Synonyms=T2r25;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000312|EMBL:AAR13354.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAR13354.1};
RA Conte C., Ebeling M., Marcuz A., Andres-Barquin P.J.;
RT "Identification of new putative rat taste receptors belonging to the T2R
RT family.";
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Putative taste receptor which may play a role in the
CC perception of bitterness. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000255}.
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DR EMBL; AY362745; AAR13354.1; -; Genomic_DNA.
DR RefSeq; NP_001074407.1; NM_001080938.1.
DR AlphaFoldDB; Q67ES5; -.
DR SMR; Q67ES5; -.
DR STRING; 10116.ENSRNOP00000030727; -.
DR GlyGen; Q67ES5; 3 sites.
DR PaxDb; Q67ES5; -.
DR Ensembl; ENSRNOT00000030813; ENSRNOP00000030727; ENSRNOG00000021430.
DR GeneID; 690472; -.
DR KEGG; rno:690472; -.
DR UCSC; RGD:1596038; rat.
DR CTD; 387351; -.
DR RGD; 1596038; Tas2r124.
DR eggNOG; ENOG502TE6X; Eukaryota.
DR GeneTree; ENSGT00960000186648; -.
DR HOGENOM; CLU_072337_2_0_1; -.
DR InParanoid; Q67ES5; -.
DR OMA; ELVHIIC; -.
DR OrthoDB; 1123629at2759; -.
DR PhylomeDB; Q67ES5; -.
DR TreeFam; TF335891; -.
DR PRO; PR:Q67ES5; -.
DR Proteomes; UP000002494; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0033038; F:bitter taste receptor activity; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..309
FT /note="Taste receptor type 2 member 124"
FT /id="PRO_0000248482"
FT TOPO_DOM 1..7
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..81
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..127
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..182
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..227
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 249..261
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 283..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 160
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 180
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 255
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 309 AA; 35786 MW; 23DFD306F735AF1C CRC64;
MVSVLHSIST IIIIAEFVWG NLSNGLIVLK NCLDWINIKE LSTLDQILIL LAISRISLIW
ETLLMWVKDK LISSITIEEL KMIMFSFMLS SHFSLWLATA LSTFYLFRIA NCSWQIFLYL
KWRLKHLIVQ MLLGSVMFLI ANIIQITITL EKRFYQYKGN TSVNSIQNEF ALLIEMMLFN
MTIFSVIPFL LALISFFLLI FSLWKHLQRM QLNSREDRDP STKAHRNALG IMVSFLLLYT
MYVLSLLISW IAQKNQSELV HIICMITSLL NPSVHSSILI LGNFKLKQSS LCILRHLGCR
LKSQNTPTT
