TR129_MOUSE
ID TR129_MOUSE Reviewed; 320 AA.
AC Q7M709;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Taste receptor type 2 member 129;
DE Short=T2R129;
DE Short=mT2R60;
GN Name=Tas2r129 {ECO:0000312|MGI:MGI:2681276};
GN Synonyms=T2r60 {ECO:0000303|PubMed:12679530};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000305, ECO:0000312|EMBL:DAA01227.1}
RP IDENTIFICATION.
RX PubMed=12679530; DOI=10.1093/molbev/msg083;
RA Shi P., Zhang J., Yang H., Zhang Y.-P.;
RT "Adaptive diversification of bitter taste receptor genes in mammalian
RT evolution.";
RL Mol. Biol. Evol. 20:805-814(2003).
CC -!- FUNCTION: Putative taste receptor which may play a role in the
CC perception of bitterness. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000255}.
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DR EMBL; AC129318; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK001088; DAA01227.1; -; Genomic_DNA.
DR CCDS; CCDS20629.1; -.
DR RefSeq; NP_996912.1; NM_207029.1.
DR AlphaFoldDB; Q7M709; -.
DR SMR; Q7M709; -.
DR STRING; 10090.ENSMUSP00000067640; -.
DR GlyGen; Q7M709; 1 site.
DR PaxDb; Q7M709; -.
DR PRIDE; Q7M709; -.
DR DNASU; 387354; -.
DR Ensembl; ENSMUST00000070991; ENSMUSP00000067640; ENSMUSG00000063762.
DR GeneID; 387354; -.
DR KEGG; mmu:387354; -.
DR UCSC; uc009ejv.1; mouse.
DR CTD; 387354; -.
DR MGI; MGI:2681276; Tas2r129.
DR VEuPathDB; HostDB:ENSMUSG00000063762; -.
DR eggNOG; ENOG502SKRK; Eukaryota.
DR GeneTree; ENSGT00960000186648; -.
DR HOGENOM; CLU_072337_3_0_1; -.
DR InParanoid; Q7M709; -.
DR OMA; MWLAACL; -.
DR OrthoDB; 1010573at2759; -.
DR PhylomeDB; Q7M709; -.
DR TreeFam; TF335891; -.
DR BioGRID-ORCS; 387354; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Tas2r129; mouse.
DR PRO; PR:Q7M709; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q7M709; protein.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0033038; F:bitter taste receptor activity; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0008527; F:taste receptor activity; ISO:MGI.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..320
FT /note="Taste receptor type 2 member 129"
FT /id="PRO_0000248485"
FT TOPO_DOM 1..8
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 9..29
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 30..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..88
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 110..128
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..185
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 207..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..264
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..320
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 170
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 320 AA; 37178 MW; F8DD1BCA7517300F CRC64;
MDGIVQNMFT FIVIVEIIIG WIGNGFIALV NCIHWYKRRK ISALNQILTA LAFSRIYLLL
TVFTVIAVST LYTHVLVTRR VVKLINFHLL FSNHFSMWLA ACLGLYYFLK IAHFPNSIFV
YLKMRINQVV SGTLLMSLGL LFLNTLLINS YIDTKIDDYR EHLLYDFTSN NTASFYRVIL
VINNCIFTSI PFTLSQSTFL LLIFSLWRHY KKMQQHAQRC RDVLADAHIR VLQTMVTYVL
LCAIFFLSLS MQILRSELLK NILYVRFCEI VAAVFPSGHS CVLICRDTNL RGTFLSVLSW
LKQRFTSWIP NINCRSSCIF
