ID   TR129_RAT               Reviewed;         315 AA.
AC   Q67ES6;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Taste receptor type 2 member 129;
DE            Short=T2R129;
DE   AltName: Full=Taste receptor type 2 member 24;
DE            Short=T2R24;
GN   Name=Tas2r129 {ECO:0000250|UniProtKB:Q7M709}; Synonyms=T2r24;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:AAR13353.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAR13353.1};
RA   Conte C., Ebeling M., Marcuz A., Andres-Barquin P.J.;
RT   "Identification of new putative rat taste receptors belonging to the T2R
RT   family.";
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative taste receptor which may play a role in the
CC       perception of bitterness. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC       taste receptor cell. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000255}.
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DR   EMBL; AY362744; AAR13353.1; -; Genomic_DNA.
DR   RefSeq; NP_001160155.1; NM_001166683.1.
DR   AlphaFoldDB; Q67ES6; -.
DR   SMR; Q67ES6; -.
DR   GlyGen; Q67ES6; 1 site.
DR   PaxDb; Q67ES6; -.
DR   Ensembl; ENSRNOT00000051110; ENSRNOP00000048668; ENSRNOG00000031107.
DR   GeneID; 100310881; -.
DR   KEGG; rno:100310881; -.
DR   UCSC; RGD:2314257; rat.
DR   CTD; 387354; -.
DR   RGD; 2314257; Tas2r129.
DR   GeneTree; ENSGT00960000186648; -.
DR   HOGENOM; CLU_072337_3_0_1; -.
DR   InParanoid; Q67ES6; -.
DR   OMA; MWLAACL; -.
DR   OrthoDB; 1010573at2759; -.
DR   PhylomeDB; Q67ES6; -.
DR   TreeFam; TF335891; -.
DR   PRO; PR:Q67ES6; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0033038; F:bitter taste receptor activity; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR   InterPro; IPR007960; TAS2R.
DR   Pfam; PF05296; TAS2R; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..315
FT                   /note="Taste receptor type 2 member 129"
FT                   /id="PRO_0000248486"
FT   TOPO_DOM        1..9
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        10..30
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        31..46
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        47..67
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        68..101
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        123..128
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        150..185
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        207..233
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        255..266
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..287
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        288..315
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        170
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   315 AA;  37033 MW;  7C3C6B802B5E2ED3 CRC64;
     MDGIIQIISA FIVIIEIIIG WFGNGFIVLV NCMHWIKRRR ISTVNQILTA LAFSRIYLLL
     TVFTVILASV QYSNILVTRR EVKVIIFHLI TSNHFSMWLA ACLGLFYFLK IANFSNFIFV
     FLKKRVNKVV SGTLLMSLVF LFLNTLLINS YIDAQIDDYR GYLLYDFTSN ITVSFYRVIL
     VINNCIFTSI PFALSQSTFL MLIFSLWRHY KKMQQHAQRC RDTLTNAHIK VLQTMIMYVL
     LSAIFFLFLS MQIWRNKLME NILFIRFCET VAAVFPSGHS CVLIWGDTNL RQTFLSVLWW
     LKHRFTLWVP KLYCR