TR134_MOUSE
ID TR134_MOUSE Reviewed; 298 AA.
AC Q7TQB0; Q4VHF1;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Taste receptor type 2 member 134;
DE Short=T2R134;
DE AltName: Full=Taste receptor type 2 member 34;
DE Short=T2R34;
GN Name=Tas2r134; Synonyms=Tas2r34;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|EMBL:AAP40335.1};
RN [1] {ECO:0000312|EMBL:AAP40335.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAP40335.1};
RX PubMed=12734386; DOI=10.1152/physiolgenomics.00060.2003;
RA Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.;
RT "Evolutionary relationships of the Tas2r receptor gene families in mouse
RT and human.";
RL Physiol. Genomics 14:73-82(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=15886333; DOI=10.1152/physiolgenomics.00030.2005;
RA Wu S.V., Chen M.C., Rozengurt E.;
RT "Genomic organization, expression, and function of bitter taste receptors
RT (T2R) in mouse and rat.";
RL Physiol. Genomics 22:139-149(2005).
CC -!- FUNCTION: Putative taste receptor which may play a role in the
CC perception of bitterness. {ECO:0000303|PubMed:12734386}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
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DR EMBL; AF532785; AAP40335.1; -; Genomic_DNA.
DR EMBL; AY916508; AAX99131.1; -; mRNA.
DR CCDS; CCDS16029.1; -.
DR RefSeq; NP_954609.1; NM_199158.1.
DR AlphaFoldDB; Q7TQB0; -.
DR SMR; Q7TQB0; -.
DR STRING; 10090.ENSMUSP00000064657; -.
DR GlyGen; Q7TQB0; 1 site.
DR PaxDb; Q7TQB0; -.
DR PRIDE; Q7TQB0; -.
DR DNASU; 387511; -.
DR Ensembl; ENSMUST00000070028; ENSMUSP00000064657; ENSMUSG00000056115.
DR GeneID; 387511; -.
DR KEGG; mmu:387511; -.
DR UCSC; uc008jqj.1; mouse.
DR CTD; 387511; -.
DR MGI; MGI:2681300; Tas2r134.
DR VEuPathDB; HostDB:ENSMUSG00000056115; -.
DR eggNOG; ENOG502S2SI; Eukaryota.
DR GeneTree; ENSGT00960000186648; -.
DR HOGENOM; CLU_072337_1_1_1; -.
DR InParanoid; Q7TQB0; -.
DR OMA; WAWEVLI; -.
DR OrthoDB; 1282504at2759; -.
DR PhylomeDB; Q7TQB0; -.
DR TreeFam; TF335891; -.
DR BioGRID-ORCS; 387511; 5 hits in 71 CRISPR screens.
DR PRO; PR:Q7TQB0; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q7TQB0; protein.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0033038; F:bitter taste receptor activity; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0008527; F:taste receptor activity; NAS:UniProtKB.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..298
FT /note="Taste receptor type 2 member 134"
FT /id="PRO_0000082269"
FT TOPO_DOM 1..6
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 7..27
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 28..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..96
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..128
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..176
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 198..229
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 251..257
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..298
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 158
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 97
FT /note="W -> C (in Ref. 2; AAX99131)"
FT /evidence="ECO:0000305"
FT CONFLICT 165
FT /note="M -> T (in Ref. 2; AAX99131)"
FT /evidence="ECO:0000305"
FT CONFLICT 239
FT /note="T -> A (in Ref. 2; AAX99131)"
FT /evidence="ECO:0000305"
FT CONFLICT 243
FT /note="T -> M (in Ref. 2; AAX99131)"
FT /evidence="ECO:0000305"
FT CONFLICT 287
FT /note="K -> M (in Ref. 2; AAX99131)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 298 AA; 34628 MW; 0F0701A66EC379C3 CRC64;
MSFSHSFIFI VIFCMQSLAA LLQNGFMATV LGREWVRSQG LPAGDMIMAC LAASRFCLHG
IAVLNNFLAS AMFWTIKNYF SILWDFTNTV NFWFTTWLAI FYCVKISSFS HPIFFWIKWR
ISRSVPRLLL GSLIIGGLSA ISSATGNTIA LQMAACENYT IYYKMMAFYL YYFRCHAMLM
WVIPFFLFLL SIILLMFSLY RHLEQMRYHR PRTHDYSTQA HIMALKSLAF FLIFYTSYTL
LLTVSVAHVI NVHGSWHWAW EVVTYMGISL HSTILILSNT KMRKALKIKF PDLCIPRS
