TR134_RAT
ID TR134_RAT Reviewed; 329 AA.
AC Q67ES7; Q4VHE8;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Taste receptor type 2 member 134;
DE Short=T2R134;
DE Short=T2R34;
DE AltName: Full=Taste receptor type 2 member 23;
DE Short=T2R23;
GN Name=Tas2r134 {ECO:0000312|RGD:1359393}; Synonyms=Tas2r23, Tas2r34;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000312|EMBL:AAR13352.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAR13352.1};
RA Conte C., Ebeling M., Marcuz A., Andres-Barquin P.J.;
RT "Identification of new putative rat taste receptors belonging to the T2R
RT family.";
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAX99134.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 28-329, AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley {ECO:0000269|PubMed:15886333};
RC TISSUE=Gastrointestinal tract {ECO:0000269|PubMed:15886333};
RX PubMed=15886333; DOI=10.1152/physiolgenomics.00030.2005;
RA Wu S.V., Chen M.C., Rozengurt E.;
RT "Genomic organization, expression, and function of bitter taste receptors
RT (T2R) in mouse and rat.";
RL Physiol. Genomics 22:139-149(2005).
CC -!- FUNCTION: Putative taste receptor which may play a role in the
CC perception of bitterness. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in tongue and gastrointestinal tract.
CC {ECO:0000269|PubMed:15886333}.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAX99134.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY362743; AAR13352.1; -; Genomic_DNA.
DR EMBL; AY916511; AAX99134.1; ALT_INIT; mRNA.
DR RefSeq; NP_001013937.1; NM_001013915.1.
DR AlphaFoldDB; Q67ES7; -.
DR SMR; Q67ES7; -.
DR STRING; 10116.ENSRNOP00000038705; -.
DR GlyGen; Q67ES7; 1 site.
DR PaxDb; Q67ES7; -.
DR Ensembl; ENSRNOT00000030442; ENSRNOP00000038705; ENSRNOG00000027510.
DR GeneID; 295589; -.
DR KEGG; rno:295589; -.
DR UCSC; RGD:1359393; rat.
DR CTD; 387511; -.
DR RGD; 1359393; Tas2r134.
DR eggNOG; ENOG502S2SI; Eukaryota.
DR GeneTree; ENSGT00960000186648; -.
DR HOGENOM; CLU_072337_1_1_1; -.
DR InParanoid; Q67ES7; -.
DR OMA; WAWEVLI; -.
DR OrthoDB; 1282504at2759; -.
DR PhylomeDB; Q67ES7; -.
DR TreeFam; TF335891; -.
DR PRO; PR:Q67ES7; -.
DR Proteomes; UP000002494; Chromosome 3.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0033038; F:bitter taste receptor activity; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IDA:MGI.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..329
FT /note="Taste receptor type 2 member 134"
FT /id="PRO_0000247661"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..68
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 69..89
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 90..121
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 143..153
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 175..201
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 223..251
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..282
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 283..303
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 304..329
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 183
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 329 AA; 38062 MW; 90CAEB5330BDA7F4 CRC64;
MRCSLRGCVQ GRGGKSGVSL SKFSPKKMSF FFIFMVIFCI QSLVALLQNG FLATVLGREW
VRSQGLPAGD MIVACLAASR FCLHGVAIVN NFLTFVKLWS QKIYFSVLWD FVNTVNFWCT
TWLAIFYCVK ISSFSHPIFF WIKWRISRSV PRLLLGSLVI GGLSAVSSAT GNTIAFQMTA
CENYTLAYRT RAFYAYYFRC HAMLMWIIPF FLFLLSVILL MFSLYRHLEH MRYRRPWSHD
YSTQAHTMAL KSLAFFLVFY TSYVLFLVIS VTRVVNVHSS WHWAWEVITY MGILLHSTIL
TLSNPKMRKA LKIKFPDLCV ARSQDKRRG
