TR136_MOUSE
ID TR136_MOUSE Reviewed; 305 AA.
AC Q7TQA8; Q7M716;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-JAN-2004, sequence version 2.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=Taste receptor type 2 member 136;
DE Short=T2R136;
DE AltName: Full=Taste receptor type 2 member 36;
DE Short=T2R36;
DE Short=mT2r52;
GN Name=Tas2r136; Synonyms=T2r52, Tas2r36;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|EMBL:AAP40337.1};
RN [1] {ECO:0000312|EMBL:AAP40337.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAP40337.1};
RX PubMed=12734386; DOI=10.1152/physiolgenomics.00060.2003;
RA Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.;
RT "Evolutionary relationships of the Tas2r receptor gene families in mouse
RT and human.";
RL Physiol. Genomics 14:73-82(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=12679530; DOI=10.1093/molbev/msg083;
RA Shi P., Zhang J., Yang H., Zhang Y.-P.;
RT "Adaptive diversification of bitter taste receptor genes in mammalian
RT evolution.";
RL Mol. Biol. Evol. 20:805-814(2003).
CC -!- FUNCTION: Putative taste receptor which may play a role in the
CC perception of bitterness. {ECO:0000303|PubMed:12734386}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAP40337.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF532787; AAP40337.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC153022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK001081; DAA01220.1; -; Genomic_DNA.
DR RefSeq; NP_851793.1; NM_181276.1.
DR AlphaFoldDB; Q7TQA8; -.
DR SMR; Q7TQA8; -.
DR STRING; 10090.ENSMUSP00000070791; -.
DR iPTMnet; Q7TQA8; -.
DR PhosphoSitePlus; Q7TQA8; -.
DR PaxDb; Q7TQA8; -.
DR PRIDE; Q7TQA8; -.
DR DNASU; 353165; -.
DR GeneID; 353165; -.
DR KEGG; mmu:353165; -.
DR UCSC; uc009ejo.1; mouse.
DR CTD; 353165; -.
DR MGI; MGI:2681304; Tas2r136.
DR eggNOG; ENOG502TE6U; Eukaryota.
DR InParanoid; Q7TQA8; -.
DR OrthoDB; 1339037at2759; -.
DR PhylomeDB; Q7TQA8; -.
DR TreeFam; TF335891; -.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR Reactome; R-MMU-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Reactome; R-MMU-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR BioGRID-ORCS; 353165; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q7TQA8; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q7TQA8; protein.
DR GO; GO:0016021; C:integral component of membrane; ISO:MGI.
DR GO; GO:0031514; C:motile cilium; ISO:MGI.
DR GO; GO:0033038; F:bitter taste receptor activity; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0008527; F:taste receptor activity; ISO:MGI.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor; Membrane; Receptor; Reference proteome;
KW Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..305
FT /note="Taste receptor type 2 member 136"
FT /id="PRO_0000082271"
FT TOPO_DOM 1..9
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 10..30
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 31..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..69
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..99
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..127
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..176
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 177..197
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 198..223
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 245..305
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 305 AA; 35019 MW; B777E1F5E3B79563 CRC64;
MMSFLVSIAS IAMLVKIVLG TFANVFIVLV NFTDCIKKRK FLLADRILTV LAIFRFDLLW
IILMNWSSSV FHVGLYFQVR FCICVVWIVT NHFNTWLANI LSILYLLKID NFSNLIFLGL
KGKIKCPYIV LLPCFVLLFP NLIMVTICET TQANGHQGNL TGKTKLTYFT NLIAMTFTLG
SLVPFTTFMI CFLLLICSLC KHLRTMRLYG KGSQGPSAST HIKVLQVLIS FLLLFSMFIL
LLIISDYNYT KSLEEPIHLI CQVIGTLYPS RHSYILLWGN KRIKQAFVLA MVQVRARFWL
KEKKP
