ID   TR136_RAT               Reviewed;         330 AA.
AC   Q675B7;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Taste receptor type 2 member 136;
DE            Short=T2R136;
DE   AltName: Full=Taste receptor type 2 member 40;
DE            Short=T2R40;
GN   Name=Tas2r136 {ECO:0000250|UniProtKB:Q7TQA8}; Synonyms=Tas2r40;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:AAS57911.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAS57911.1};
RA   Conte C., Ebeling M., Marcuz A., Andres-Barquin P.J.;
RT   "Identification of new putative rat taste receptors belonging to the T2R
RT   family.";
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative taste receptor which may play a role in the
CC       perception of bitterness. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC       taste receptor cell. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000255}.
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DR   EMBL; AY486340; AAS57911.1; -; Genomic_DNA.
DR   RefSeq; NP_001160150.1; NM_001166678.1.
DR   AlphaFoldDB; Q675B7; -.
DR   SMR; Q675B7; -.
DR   STRING; 10116.ENSRNOP00000048980; -.
DR   GlyGen; Q675B7; 2 sites.
DR   PaxDb; Q675B7; -.
DR   PRIDE; Q675B7; -.
DR   Ensembl; ENSRNOT00000052034; ENSRNOP00000048980; ENSRNOG00000029561.
DR   GeneID; 100310876; -.
DR   KEGG; rno:100310876; -.
DR   UCSC; RGD:2314262; rat.
DR   CTD; 353165; -.
DR   RGD; 2314262; Tas2r136.
DR   eggNOG; ENOG502TE6U; Eukaryota.
DR   GeneTree; ENSGT00960000186648; -.
DR   HOGENOM; CLU_072337_2_0_1; -.
DR   InParanoid; Q675B7; -.
DR   OMA; CWAKGQN; -.
DR   OrthoDB; 1339037at2759; -.
DR   PhylomeDB; Q675B7; -.
DR   TreeFam; TF335891; -.
DR   Reactome; R-RNO-418594; G alpha (i) signalling events.
DR   Reactome; R-RNO-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR   Reactome; R-RNO-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR   PRO; PR:Q675B7; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0033038; F:bitter taste receptor activity; ISO:RGD.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:RGD.
DR   InterPro; IPR007960; TAS2R.
DR   Pfam; PF05296; TAS2R; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..330
FT                   /note="Taste receptor type 2 member 136"
FT                   /id="PRO_0000247663"
FT   TOPO_DOM        1..32
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..53
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        54..73
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        95..122
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        123..143
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        144..149
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        171..201
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        223..248
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        249..269
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        270..283
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        284..304
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        305..330
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        183
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        195
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   330 AA;  37358 MW;  A002D1AC183CDD3F CRC64;
     MKSQPVTQEL HFIFPLFKTI SSDIMSFLVS IAGIAMLAQI VLGTFANVFI VLVTCTDCIR
     RRKLFLADGI LTSLAFCRIG MLWVILISWC SIVFHQALSL QVRFSICVGW AVTNHFNMWL
     ATILSILYLL KIGNFSNLIF LGLKRKIKSV FIVVLLASLV LLFPNLITVT VCETVQANGY
     RGNLTGKTKR TYFMNLTAMI SFTLDNIISF TISMVCFLLL IYSLCKHLRT MRLYGKGPHN
     PSASAHIKAL QAVISFLLLF SMFILSLIIS GYNYMKPLNE PVHLICQLIG TLYPSSHSYV
     LLWGNRRIKL AFVLAMVQVR ARLWLKEEKP