TR13B_MOUSE
ID TR13B_MOUSE Reviewed; 249 AA.
AC Q9ET35; Q9DBZ3;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Tumor necrosis factor receptor superfamily member 13B;
DE AltName: Full=Transmembrane activator and CAML interactor;
DE AltName: CD_antigen=CD267;
GN Name=Tnfrsf13b; Synonyms=Taci;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Spleen;
RX PubMed=10881172; DOI=10.1038/76889;
RA Yan M., Marsters S.A., Grewal I.S., Wang H., Ashkenazi A., Dixit V.M.;
RT "Identification of a receptor for BLyS demonstrates a crucial role in
RT humoral immunity.";
RL Nat. Immunol. 1:37-41(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP FUNCTION.
RX PubMed=10880535; DOI=10.1084/jem.192.1.137;
RA Xia X.-Z., Treanor J., Senaldi G., Khare S.D., Boone T., Kelley M.,
RA Theill L.E., Colombero A., Solovyev I., Lee F., McCabe S., Elliott R.,
RA Miner K., Hawkins N., Guo J., Stolina M., Yu G., Wang J., Delaney J.,
RA Meng S.-Y., Boyle W.J., Hsu H.;
RT "TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor
RT family member involved in B cell regulation.";
RL J. Exp. Med. 192:137-143(2000).
RN [4]
RP FUNCTION.
RX PubMed=11429548; DOI=10.1038/89782;
RA Wang H., Marsters S.A., Baker T., Chan B., Lee W.P., Fu L., Tumas D.,
RA Yan M., Dixit V.M., Ashkenazi A., Grewal I.S.;
RT "TACI-ligand interactions are required for T cell activation and collagen-
RT induced arthritis in mice.";
RL Nat. Immunol. 2:632-637(2001).
CC -!- FUNCTION: Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that
CC binds both ligands with similar high affinity. Mediates calcineurin-
CC dependent activation of NF-AT, as well as activation of NF-kappa-B and
CC AP-1. Involved in the stimulation of B- and T-cell function and the
CC regulation of humoral immunity (By similarity). {ECO:0000250,
CC ECO:0000269|PubMed:10880535, ECO:0000269|PubMed:11429548}.
CC -!- SUBUNIT: Binds TRAF2, TRAF5 and TRAF6. Binds the NH2-terminal domain of
CC CAMLG with its C-terminus (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III
CC membrane protein {ECO:0000305}.
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DR EMBL; AF257673; AAG00081.1; -; mRNA.
DR EMBL; AK004668; BAB23457.1; -; mRNA.
DR CCDS; CCDS24806.1; -.
DR RefSeq; NP_067324.1; NM_021349.1.
DR RefSeq; XP_006533914.1; XM_006533851.3.
DR RefSeq; XP_006533915.1; XM_006533852.3.
DR AlphaFoldDB; Q9ET35; -.
DR SMR; Q9ET35; -.
DR IntAct; Q9ET35; 6.
DR STRING; 10090.ENSMUSP00000010286; -.
DR iPTMnet; Q9ET35; -.
DR PhosphoSitePlus; Q9ET35; -.
DR PaxDb; Q9ET35; -.
DR PRIDE; Q9ET35; -.
DR ProteomicsDB; 259178; -.
DR Antibodypedia; 35076; 657 antibodies from 44 providers.
DR DNASU; 57916; -.
DR Ensembl; ENSMUST00000010286; ENSMUSP00000010286; ENSMUSG00000010142.
DR Ensembl; ENSMUST00000101103; ENSMUSP00000098662; ENSMUSG00000010142.
DR GeneID; 57916; -.
DR KEGG; mmu:57916; -.
DR UCSC; uc007jha.1; mouse.
DR CTD; 23495; -.
DR MGI; MGI:1889411; Tnfrsf13b.
DR VEuPathDB; HostDB:ENSMUSG00000010142; -.
DR eggNOG; ENOG502SANG; Eukaryota.
DR GeneTree; ENSGT00390000013910; -.
DR HOGENOM; CLU_086237_0_0_1; -.
DR InParanoid; Q9ET35; -.
DR OMA; CHCREDP; -.
DR OrthoDB; 1441661at2759; -.
DR PhylomeDB; Q9ET35; -.
DR TreeFam; TF337993; -.
DR Reactome; R-MMU-5669034; TNFs bind their physiological receptors.
DR BioGRID-ORCS; 57916; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q9ET35; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9ET35; protein.
DR Bgee; ENSMUSG00000010142; Expressed in spleen and 73 other tissues.
DR ExpressionAtlas; Q9ET35; baseline and differential.
DR Genevisible; Q9ET35; MM.
DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:MGI.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0001782; P:B cell homeostasis; IDA:MGI.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IMP:MGI.
DR GO; GO:0030889; P:negative regulation of B cell proliferation; IMP:MGI.
DR CDD; cd13415; TNFRSF13B; 1.
DR InterPro; IPR015384; TACI_Cys-rich-dom.
DR InterPro; IPR022317; TNFR_13B.
DR PANTHER; PTHR15511; PTHR15511; 1.
DR Pfam; PF09305; TACI-CRD2; 1.
DR PRINTS; PR01963; TNFACTORR13B.
PE 2: Evidence at transcript level;
KW Adaptive immunity; Disulfide bond; Immunity; Membrane; Receptor;
KW Reference proteome; Repeat; Signal-anchor; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..249
FT /note="Tumor necrosis factor receptor superfamily member
FT 13B"
FT /id="PRO_0000058932"
FT TOPO_DOM 1..128
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical; Signal-anchor for type III membrane
FT protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..249
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 5..38
FT /note="TNFR-Cys 1"
FT REPEAT 42..76
FT /note="TNFR-Cys 2"
FT REGION 86..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 156..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 6..19
FT /evidence="ECO:0000250"
FT DISULFID 22..34
FT /evidence="ECO:0000250"
FT DISULFID 26..38
FT /evidence="ECO:0000250"
FT DISULFID 43..58
FT /evidence="ECO:0000250"
FT DISULFID 61..72
FT /evidence="ECO:0000250"
FT DISULFID 65..76
FT /evidence="ECO:0000250"
FT CONFLICT 137
FT /note="I -> F (in Ref. 2; BAB23457)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 249 AA; 26947 MW; CB2F2D61C2931D81 CRC64;
MAMAFCPKDQ YWDSSRKSCV SCALTCSQRS QRTCTDFCKF INCRKEQGRY YDHLLGACVS
CDSTCTQHPQ QCAHFCEKRP RSQANLQPEL GRPQAGEVEV RSDNSGRHQG SEHGPGLRLS
SDQLTLYCTL GVCLCAIFCC FLVALASFLR RRGEPLPSQP AGPRGSQANS PHAHRPVTEA
CDEVTASPQP VETCSFCFPE RSSPTQESAP RSLGIHGFAG TAAPQPCMRA TVGGLGVLRA
STGDARPAT
