TR143_MOUSE
ID TR143_MOUSE Reviewed; 293 AA.
AC Q7TQB9; A7MAX5; Q2NL43;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Taste receptor type 2 member 143;
DE Short=T2R143;
DE AltName: Full=Taste receptor type 2 member 43;
DE Short=T2R43;
DE Short=mT2R36;
GN Name=Tas2r143; Synonyms=T2r36, Tas2r43;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|EMBL:AAN63042.1};
RN [1] {ECO:0000312|EMBL:AAN63042.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAN63042.1};
RX PubMed=12734386; DOI=10.1152/physiolgenomics.00060.2003;
RA Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J.;
RT "Evolutionary relationships of the Tas2r receptor gene families in mouse
RT and human.";
RL Physiol. Genomics 14:73-82(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4] {ECO:0000305}
RP IDENTIFICATION.
RX PubMed=12679530; DOI=10.1093/molbev/msg083;
RA Shi P., Zhang J., Yang H., Zhang Y.-P.;
RT "Adaptive diversification of bitter taste receptor genes in mammalian
RT evolution.";
RL Mol. Biol. Evol. 20:805-814(2003).
CC -!- FUNCTION: Putative taste receptor which may play a role in the
CC perception of bitterness. {ECO:0000303|PubMed:12734386}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
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DR EMBL; AY145467; AAN63042.1; -; Genomic_DNA.
DR EMBL; AC153022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC111103; AAI11104.1; -; mRNA.
DR EMBL; BC148239; AAI48240.1; -; mRNA.
DR EMBL; BK001096; DAA01235.1; -; Genomic_DNA.
DR CCDS; CCDS20068.1; -.
DR RefSeq; NP_001001452.1; NM_001001452.1.
DR AlphaFoldDB; Q7TQB9; -.
DR SMR; Q7TQB9; -.
DR STRING; 10090.ENSMUSP00000057910; -.
DR GlyGen; Q7TQB9; 1 site.
DR PaxDb; Q7TQB9; -.
DR PRIDE; Q7TQB9; -.
DR DNASU; 387514; -.
DR Ensembl; ENSMUST00000057398; ENSMUSP00000057910; ENSMUSG00000046652.
DR GeneID; 387514; -.
DR KEGG; mmu:387514; -.
DR UCSC; uc009brf.1; mouse.
DR CTD; 387514; -.
DR MGI; MGI:2681310; Tas2r143.
DR VEuPathDB; HostDB:ENSMUSG00000046652; -.
DR eggNOG; ENOG502S2SI; Eukaryota.
DR GeneTree; ENSGT00960000186648; -.
DR HOGENOM; CLU_072337_1_1_1; -.
DR InParanoid; Q7TQB9; -.
DR OMA; WVCQVVI; -.
DR OrthoDB; 1282504at2759; -.
DR PhylomeDB; Q7TQB9; -.
DR TreeFam; TF335891; -.
DR BioGRID-ORCS; 387514; 0 hits in 71 CRISPR screens.
DR PRO; PR:Q7TQB9; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q7TQB9; protein.
DR Bgee; ENSMUSG00000046652; Expressed in dorsal root ganglion and 24 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0033038; F:bitter taste receptor activity; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0008527; F:taste receptor activity; NAS:UniProtKB.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..293
FT /note="Taste receptor type 2 member 143"
FT /id="PRO_0000082307"
FT TOPO_DOM 1..6
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 7..27
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 28..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..79
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 101..127
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..181
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 203..227
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 249..264
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..293
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 162
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 293 AA; 34045 MW; DC9C218CBDF41973 CRC64;
MPSTPTLIFI IIFYLVSLAS MLQNGFMMIV LGREWMRNRT LPAADMIVAS LASSRFCLHG
IAILANLLAS FDFCYQANLI GILWDFTNTL IFWLTAWLAI FYCVKISSFS HPVLFWLKWR
ISQLVPRLLV VSLIIGGLSA VISATGNFMA NQMTISQGFH GNCTFGHMSL DFYRYYYLYH
SVLMWFTPFF LFLVSVIVLM FSLYQHVEKM RGHRPGPWDL HTQAHTMALK SLTFFFIFYI
FFFLALVISS TKRKSMQSYY WAREAIIYTG IFLNSIILLF SNPKLRKALK MRF
