TR16L_HUMAN
ID TR16L_HUMAN Reviewed; 348 AA.
AC Q309B1; A0PK10; B2RUW6; B4DQK2; B4DWQ8;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Tripartite motif-containing protein 16-like protein;
DE AltName: Full=Tripartite motif-containing protein 70;
GN Name=TRIM16L; Synonyms=TRIM70;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Corcoran M., Grander D., Sangfelt O., Lerner M.;
RT "Characterization of the human TRIM70 gene.";
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Esophagus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q309B1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q309B1-2; Sequence=VSP_044369, VSP_044370;
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family. {ECO:0000305}.
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DR EMBL; DQ232882; ABB18375.1; -; mRNA.
DR EMBL; AK298836; BAG60964.1; -; mRNA.
DR EMBL; AK301639; BAG63120.1; -; mRNA.
DR EMBL; AK301647; BAH13530.1; -; mRNA.
DR EMBL; AK316368; BAH14739.1; -; mRNA.
DR EMBL; AC026271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC107982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC127827; AAI27828.1; -; mRNA.
DR EMBL; BC128591; AAI28592.1; -; mRNA.
DR EMBL; BC146907; AAI46908.1; -; mRNA.
DR EMBL; BC146902; AAI46903.1; -; mRNA.
DR RefSeq; NP_001032407.1; NM_001037330.1. [Q309B1-1]
DR RefSeq; XP_005256538.1; XM_005256481.4.
DR RefSeq; XP_005256540.1; XM_005256483.4.
DR RefSeq; XP_011521992.1; XM_011523690.2. [Q309B1-1]
DR RefSeq; XP_016879734.1; XM_017024245.1. [Q309B1-1]
DR RefSeq; XP_016879735.1; XM_017024246.1. [Q309B1-1]
DR RefSeq; XP_016879736.1; XM_017024247.1. [Q309B1-1]
DR RefSeq; XP_016879737.1; XM_017024248.1. [Q309B1-1]
DR RefSeq; XP_016879738.1; XM_017024249.1. [Q309B1-1]
DR RefSeq; XP_016879739.1; XM_017024250.1. [Q309B1-1]
DR RefSeq; XP_016879740.1; XM_017024251.1.
DR RefSeq; XP_016879741.1; XM_017024252.1. [Q309B1-1]
DR PDB; 6SJH; X-ray; 1.50 A; A/B/C=147-332.
DR PDBsum; 6SJH; -.
DR AlphaFoldDB; Q309B1; -.
DR SMR; Q309B1; -.
DR BioGRID; 127041; 11.
DR IntAct; Q309B1; 11.
DR STRING; 9606.ENSP00000461386; -.
DR iPTMnet; Q309B1; -.
DR PhosphoSitePlus; Q309B1; -.
DR BioMuta; TRIM16L; -.
DR DMDM; 296453011; -.
DR EPD; Q309B1; -.
DR jPOST; Q309B1; -.
DR MassIVE; Q309B1; -.
DR MaxQB; Q309B1; -.
DR PaxDb; Q309B1; -.
DR PeptideAtlas; Q309B1; -.
DR PRIDE; Q309B1; -.
DR ProteomicsDB; 5371; -.
DR ProteomicsDB; 61570; -. [Q309B1-1]
DR DNASU; 147166; -.
DR GeneID; 147166; -.
DR UCSC; uc002gug.2; human. [Q309B1-1]
DR CTD; 147166; -.
DR DisGeNET; 147166; -.
DR GeneCards; TRIM16L; -.
DR HGNC; HGNC:32670; TRIM16L.
DR neXtProt; NX_Q309B1; -.
DR PharmGKB; PA144596249; -.
DR VEuPathDB; HostDB:ENSG00000108448; -.
DR eggNOG; KOG0274; Eukaryota.
DR HOGENOM; CLU_013137_0_2_1; -.
DR InParanoid; Q309B1; -.
DR OMA; EHRSAEM; -.
DR OrthoDB; 273204at2759; -.
DR PhylomeDB; Q309B1; -.
DR TreeFam; TF332213; -.
DR PathwayCommons; Q309B1; -.
DR SignaLink; Q309B1; -.
DR BioGRID-ORCS; 147166; 7 hits in 996 CRISPR screens.
DR ChiTaRS; TRIM16L; human.
DR GenomeRNAi; 147166; -.
DR Pharos; Q309B1; Tdark.
DR PRO; PR:Q309B1; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q309B1; protein.
DR Genevisible; Q309B1; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.120.920; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Cytoplasm; Reference proteome.
FT CHAIN 1..348
FT /note="Tripartite motif-containing protein 16-like protein"
FT /id="PRO_0000279515"
FT DOMAIN 139..337
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT VAR_SEQ 68..140
FT /note="EYCKFKNTEDITFPSVYIGLKDKLSGIRKVITESTVHLIQLLENYKKKLQEF
FT SKEEEYDIRTQVSAIVQRKYW -> MCMTSRSTRTQHTSISGCRRRTARSPTPRPGSIP
FT TRTSPAGSCTGGRCCPSRVCTCTGTILRWRSSGQAPMLA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044369"
FT VAR_SEQ 141..348
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044370"
FT CONFLICT 42
FT /note="R -> K (in Ref. 2; BAG60964 and 4; AAI27828/
FT AAI28592)"
FT /evidence="ECO:0000305"
FT HELIX 148..153
FT /evidence="ECO:0007829|PDB:6SJH"
FT TURN 163..165
FT /evidence="ECO:0007829|PDB:6SJH"
FT STRAND 170..173
FT /evidence="ECO:0007829|PDB:6SJH"
FT TURN 174..177
FT /evidence="ECO:0007829|PDB:6SJH"
FT STRAND 178..181
FT /evidence="ECO:0007829|PDB:6SJH"
FT STRAND 197..199
FT /evidence="ECO:0007829|PDB:6SJH"
FT STRAND 201..208
FT /evidence="ECO:0007829|PDB:6SJH"
FT STRAND 210..221
FT /evidence="ECO:0007829|PDB:6SJH"
FT STRAND 224..230
FT /evidence="ECO:0007829|PDB:6SJH"
FT HELIX 240..242
FT /evidence="ECO:0007829|PDB:6SJH"
FT STRAND 251..255
FT /evidence="ECO:0007829|PDB:6SJH"
FT STRAND 260..264
FT /evidence="ECO:0007829|PDB:6SJH"
FT STRAND 267..270
FT /evidence="ECO:0007829|PDB:6SJH"
FT STRAND 277..284
FT /evidence="ECO:0007829|PDB:6SJH"
FT TURN 285..288
FT /evidence="ECO:0007829|PDB:6SJH"
FT STRAND 289..296
FT /evidence="ECO:0007829|PDB:6SJH"
FT STRAND 299..307
FT /evidence="ECO:0007829|PDB:6SJH"
FT STRAND 314..320
FT /evidence="ECO:0007829|PDB:6SJH"
FT STRAND 326..329
FT /evidence="ECO:0007829|PDB:6SJH"
SQ SEQUENCE 348 AA; 40306 MW; 5F2D2B85A34448EB CRC64;
MQFGELLAAV RKAQANVMLF LEEKEQAALS QANGIKAHLE YRSAEMEKSK QELETMAAIS
NTVQFLEEYC KFKNTEDITF PSVYIGLKDK LSGIRKVITE STVHLIQLLE NYKKKLQEFS
KEEEYDIRTQ VSAIVQRKYW TSKPEPSTRE QFLQYVHDIT FDPDTAHKYL RLQEENRKVT
NTTPWEHPYP DLPSRFLHWR QVLSQQSLYL HRYYFEVEIF GAGTYVGLTC KGIDQKGEER
SSCISGNNFS WSLQWNGKEF TAWYSDMETP LKAGPFWRLG VYIDFPGGIL SFYGVEYDSM
TLVHKFACKF SEPVYAAFWL SKKENAIRIV DLGEEPEKPA PSLVGTAP
