ID   TR19L_MACFA             Reviewed;         430 AA.
AC   Q9N092;
DT   27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Tumor necrosis factor receptor superfamily member 19L;
DE   AltName: Full=Receptor expressed in lymphoid tissues;
DE   Flags: Precursor;
GN   Name=RELT; Synonyms=TNFRSF19L; ORFNames=QccE-10051;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RX   PubMed=11574149; DOI=10.1016/s0378-1119(01)00665-5;
RA   Osada N., Hida M., Kususda J., Tanuma R., Iseki K., Hirata M., Suto Y.,
RA   Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K.;
RT   "Assignment of 118 novel cDNAs of cynomolgus monkey brain to human
RT   chromosomes.";
RL   Gene 275:31-37(2001).
RN   [2]
RP   ERRATUM OF PUBMED:11574149.
RA   Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirata M., Suto Y.,
RA   Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K., Kususda J.;
RL   Gene 278:267-267(2001).
CC   -!- FUNCTION: May play a role in apoptosis. Induces activation of
CC       MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed. Involved in
CC       dental enamel formation. {ECO:0000250|UniProtKB:Q969Z4}.
CC   -!- SUBUNIT: Interacts with RELL1, RELL2, OXSR1, PLSCR1 and STK39.
CC       {ECO:0000250|UniProtKB:Q969Z4}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q969Z4};
CC       Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q969Z4}.
CC       Cytoplasm {ECO:0000250|UniProtKB:Q969Z4}. Cytoplasm, perinuclear region
CC       {ECO:0000250|UniProtKB:Q969Z4}.
CC   -!- PTM: Phosphorylated in vitro by OXSR1. Phosphorylated by STK39.
CC       {ECO:0000250|UniProtKB:Q969Z4}.
CC   -!- SIMILARITY: Belongs to the RELT family. {ECO:0000305}.
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DR   EMBL; AB046039; BAB01621.1; -; mRNA.
DR   RefSeq; NP_001270105.1; NM_001283176.1.
DR   AlphaFoldDB; Q9N092; -.
DR   STRING; 9541.XP_005579092.1; -.
DR   GeneID; 101865743; -.
DR   CTD; 84957; -.
DR   eggNOG; ENOG502QVCC; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0097186; P:amelogenesis; ISS:UniProtKB.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   CDD; cd13419; TNFRSF19L; 1.
DR   InterPro; IPR022248; TNF_rcpt_RELT.
DR   InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR   InterPro; IPR022333; TNFR_19-like.
DR   InterPro; IPR034048; TNFRSF19L_N.
DR   PANTHER; PTHR47397; PTHR47397; 1.
DR   Pfam; PF12606; RELT; 1.
DR   PRINTS; PR01970; TNFACTORR19L.
DR   SMART; SM00208; TNFR; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cell membrane; Cytoplasm; Disulfide bond; Glycoprotein;
KW   Membrane; Phosphoprotein; Receptor; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000250"
FT   CHAIN           27..430
FT                   /note="Tumor necrosis factor receptor superfamily member
FT                   19L"
FT                   /id="PRO_0000034600"
FT   TOPO_DOM        27..162
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        184..430
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REPEAT          50..90
FT                   /note="TNFR-Cys"
FT   REGION          134..156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          373..411
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           349..352
FT                   /note="RFRV motif; mediates interaction with STK39"
FT                   /evidence="ECO:0000250|UniProtKB:Q969Z4"
FT   MOD_RES         223
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q969Z4"
FT   CARBOHYD        149
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        51..65
FT                   /evidence="ECO:0000250"
FT   DISULFID        71..90
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   430 AA;  45851 MW;  BA8DE92593E1E859 CRC64;
     MKPSLLCRPL SCFLMLLPWP LATLTSTTLW QCPPGEEPDL NPGQGTLCRP CPPGTFSAAW
     GSSPCQPHAR CSLQRRLEAQ VGTATQDTLC GDCWPGWFGP WGVPRVPCQP CSWAPLGIHG
     CDEWGRRARR GVEVAAGASS GGETRQPGNG TRAGGPEETA AQYAVIAIVP VFCLMGLLGI
     LVCNLLKRKG YHCTAHKEVG PGPGGGGSGI NPAYRTEDVN EDTIGVLVRL ITEKKENAAA
     LEELLKEYHS KQLVQTSHRP VSKLPPAPPN VPHICPHRHH LHTVQGLASL SGPCCSRCSQ
     KKWPEVLLSP EAVAATTSAP SFLPNPTRVP KAGAKAGRQG EITILSVGRF RVARIPEQRT
     GSMVSEVKTI TEAGPSAGDL PDSPQPGLPA EQQALLGSGG SHTKWLKPPA ENKTEENRYV
     VRLSESNLVI