TR1L1_HUMAN
ID TR1L1_HUMAN Reviewed; 369 AA.
AC Q8N609; Q8N2L7;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Translocating chain-associated membrane protein 1-like 1;
GN Name=TRAM1L1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-length
RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT libraries.";
RL DNA Res. 12:117-126(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Stimulatory or required for the translocation of secretory
CC proteins across the ER membrane. {ECO:0000250}.
CC -!- INTERACTION:
CC Q8N609; P07307-3: ASGR2; NbExp=3; IntAct=EBI-11996766, EBI-12808270;
CC Q8N609; J3KQ12: BSCL2; NbExp=3; IntAct=EBI-11996766, EBI-11532900;
CC Q8N609; P19397: CD53; NbExp=3; IntAct=EBI-11996766, EBI-6657396;
CC Q8N609; P11912: CD79A; NbExp=3; IntAct=EBI-11996766, EBI-7797864;
CC Q8N609; Q8TCZ2: CD99L2; NbExp=3; IntAct=EBI-11996766, EBI-2824782;
CC Q8N609; Q8NC01: CLEC1A; NbExp=3; IntAct=EBI-11996766, EBI-11996768;
CC Q8N609; Q9BQT9: CLSTN3; NbExp=3; IntAct=EBI-11996766, EBI-11291074;
CC Q8N609; Q96BA8: CREB3L1; NbExp=3; IntAct=EBI-11996766, EBI-6942903;
CC Q8N609; Q9BQA9: CYBC1; NbExp=3; IntAct=EBI-11996766, EBI-2680384;
CC Q8N609; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-11996766, EBI-781551;
CC Q8N609; P34910-2: EVI2B; NbExp=3; IntAct=EBI-11996766, EBI-17640610;
CC Q8N609; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-11996766, EBI-18304435;
CC Q8N609; Q9Y680: FKBP7; NbExp=3; IntAct=EBI-11996766, EBI-3918971;
CC Q8N609; Q8TED1: GPX8; NbExp=3; IntAct=EBI-11996766, EBI-11721746;
CC Q8N609; Q96AG4: LRRC59; NbExp=3; IntAct=EBI-11996766, EBI-358888;
CC Q8N609; Q9GZY8-5: MFF; NbExp=3; IntAct=EBI-11996766, EBI-11956541;
CC Q8N609; P15941-11: MUC1; NbExp=3; IntAct=EBI-11996766, EBI-17263240;
CC Q8N609; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-11996766, EBI-742388;
CC Q8N609; Q53GL0: PLEKHO1; NbExp=3; IntAct=EBI-11996766, EBI-949945;
CC Q8N609; O43688: PLPP2; NbExp=3; IntAct=EBI-11996766, EBI-722017;
CC Q8N609; Q9NR31: SAR1A; NbExp=3; IntAct=EBI-11996766, EBI-3920694;
CC Q8N609; Q6PL24: TMED8; NbExp=5; IntAct=EBI-11996766, EBI-11603430;
CC Q8N609; Q4KMG9: TMEM52B; NbExp=3; IntAct=EBI-11996766, EBI-18178701;
CC Q8N609; Q9BSE2: TMEM79; NbExp=3; IntAct=EBI-11996766, EBI-8649725;
CC Q8N609; Q9Y320: TMX2; NbExp=3; IntAct=EBI-11996766, EBI-6447886;
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TRAM family. {ECO:0000305}.
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DR EMBL; AK074617; BAC11091.1; -; mRNA.
DR EMBL; BC030831; AAH30831.1; -; mRNA.
DR CCDS; CCDS3707.1; -.
DR RefSeq; NP_689615.2; NM_152402.2.
DR AlphaFoldDB; Q8N609; -.
DR BioGRID; 126347; 30.
DR IntAct; Q8N609; 27.
DR MINT; Q8N609; -.
DR STRING; 9606.ENSP00000309402; -.
DR TCDB; 9.B.311.2.3; the 6-7 tms tram-lag (tram-lag) family.
DR iPTMnet; Q8N609; -.
DR PhosphoSitePlus; Q8N609; -.
DR BioMuta; TRAM1L1; -.
DR DMDM; 166231532; -.
DR MassIVE; Q8N609; -.
DR PaxDb; Q8N609; -.
DR PeptideAtlas; Q8N609; -.
DR PRIDE; Q8N609; -.
DR ProteomicsDB; 72121; -.
DR Antibodypedia; 26589; 80 antibodies from 16 providers.
DR DNASU; 133022; -.
DR Ensembl; ENST00000310754.5; ENSP00000309402.4; ENSG00000174599.5.
DR GeneID; 133022; -.
DR KEGG; hsa:133022; -.
DR MANE-Select; ENST00000310754.5; ENSP00000309402.4; NM_152402.3; NP_689615.2.
DR UCSC; uc003ibv.5; human.
DR CTD; 133022; -.
DR DisGeNET; 133022; -.
DR GeneCards; TRAM1L1; -.
DR HGNC; HGNC:28371; TRAM1L1.
DR HPA; ENSG00000174599; Low tissue specificity.
DR MIM; 617505; gene.
DR neXtProt; NX_Q8N609; -.
DR OpenTargets; ENSG00000174599; -.
DR PharmGKB; PA134911361; -.
DR VEuPathDB; HostDB:ENSG00000174599; -.
DR eggNOG; KOG1608; Eukaryota.
DR GeneTree; ENSGT00510000046470; -.
DR HOGENOM; CLU_062830_0_0_1; -.
DR InParanoid; Q8N609; -.
DR OMA; SENCLAD; -.
DR OrthoDB; 831082at2759; -.
DR PhylomeDB; Q8N609; -.
DR TreeFam; TF314319; -.
DR PathwayCommons; Q8N609; -.
DR SignaLink; Q8N609; -.
DR BioGRID-ORCS; 133022; 46 hits in 1069 CRISPR screens.
DR GenomeRNAi; 133022; -.
DR Pharos; Q8N609; Tdark.
DR PRO; PR:Q8N609; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q8N609; protein.
DR Bgee; ENSG00000174599; Expressed in endothelial cell and 162 other tissues.
DR Genevisible; Q8N609; HS.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0045048; P:protein insertion into ER membrane; IBA:GO_Central.
DR GO; GO:0006616; P:SRP-dependent cotranslational protein targeting to membrane, translocation; IEA:InterPro.
DR InterPro; IPR006634; TLC-dom.
DR InterPro; IPR013599; TRAM1.
DR InterPro; IPR016447; Translocation_assoc_membrane.
DR PANTHER; PTHR12371; PTHR12371; 1.
DR Pfam; PF08390; TRAM1; 1.
DR Pfam; PF03798; TRAM_LAG1_CLN8; 1.
DR PIRSF; PIRSF005449; Translocation_assoc_membrane; 1.
DR SMART; SM00724; TLC; 1.
DR PROSITE; PS50922; TLC; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Membrane; Protein transport; Reference proteome;
KW Translocation; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..369
FT /note="Translocating chain-associated membrane protein 1-
FT like 1"
FT /id="PRO_0000313706"
FT TOPO_DOM 1..29
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 51..81
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 103..121
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 122..142
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 143..164
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 186..196
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..215
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 216..219
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..242
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 243..249
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 250..270
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 271..297
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 319..369
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 117..326
FT /note="TLC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00205"
FT REGION 335..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 59
FT /note="V -> A (in Ref. 2; AAH30831)"
FT /evidence="ECO:0000305"
FT CONFLICT 170
FT /note="I -> V (in Ref. 1; BAC11091)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 369 AA; 42162 MW; 95E2A5D82BEECF72 CRC64;
MGLRKKSTKN PPVLSQEFIL QNHADIVSCV GMFFLLGLVF EGTAEASIVF LTLQHSVAVP
AAEEQATGSK SLYYYGVKDL ATVFFYMLVA IIIHATIQEY VLDKINKRMQ FTKAKQNKFN
ESGQFSVFYF FSCIWGTFIL ISENCLSDPT LIWKARPHSM MTFQMKFFYI SQLAYWFHAF
PELYFQKTKK QDIPRQLVYI GLHLFHITGA YLLYLNHLGL LLLVLHYFVE LLSHMCGLFY
FSDEKYQKGI SLWAIVFILG RLVTLIVSVL TVGFHLAGSQ NRNPDALTGN VNVLAAKIAV
LSSSCTIQAY VTWNLITLWL QRWVEDSNIQ ASCMKKKRSR SSKKRTENGV GVETSNRVDC
PPKRKEKSS
