ID   TR1L1_XENLA             Reviewed;         373 AA.
AC   Q6DED0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Translocating chain-associated membrane protein 1-like 1;
GN   Name=tram1l1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stimulatory or required for the translocation of secretory
CC       proteins across the ER membrane. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAM family. {ECO:0000305}.
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DR   EMBL; BC077197; AAH77197.1; -; mRNA.
DR   RefSeq; NP_001086625.1; NM_001093156.1.
DR   AlphaFoldDB; Q6DED0; -.
DR   BioGRID; 103320; 1.
DR   GeneID; 446460; -.
DR   KEGG; xla:446460; -.
DR   CTD; 446460; -.
DR   Xenbase; XB-GENE-944949; tram1.L.
DR   OrthoDB; 831082at2759; -.
DR   Proteomes; UP000186698; Chromosome 6L.
DR   Bgee; 446460; Expressed in liver and 19 other tissues.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006616; P:SRP-dependent cotranslational protein targeting to membrane, translocation; IEA:InterPro.
DR   InterPro; IPR006634; TLC-dom.
DR   InterPro; IPR013599; TRAM1.
DR   InterPro; IPR016447; Translocation_assoc_membrane.
DR   PANTHER; PTHR12371; PTHR12371; 1.
DR   Pfam; PF08390; TRAM1; 1.
DR   Pfam; PF03798; TRAM_LAG1_CLN8; 1.
DR   PIRSF; PIRSF005449; Translocation_assoc_membrane; 1.
DR   SMART; SM00724; TLC; 1.
DR   PROSITE; PS50922; TLC; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Protein transport; Reference proteome;
KW   Translocation; Transmembrane; Transmembrane helix; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..373
FT                   /note="Translocating chain-associated membrane protein 1-
FT                   like 1"
FT                   /id="PRO_0000313708"
FT   TOPO_DOM        2..30
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        52..80
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        102..120
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        142..158
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        180..194
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        216..217
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        239..248
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        249..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        270..291
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        292..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        313..373
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          116..325
FT                   /note="TLC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00205"
FT   REGION          325..373
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   373 AA;  43100 MW;  6DA78EC542F8FBAF CRC64;
     MGIRKKSSKT PPVLSHEFII QNHADIVSCL AMVFLLGLMF EITAKAAVMF VTLQYNVTIP
     VEGVLGEQAS LYHYGIKDMA TVFFYMLVAI ILHAVIQEYI LDKINRRMHF SKTKHSKFNE
     SGQLSAFYLF SCIWGASIIV SENYFSDPIS LWKGYPHTYF PFQMKFFYIS QLAYWFHAFP
     ELYFQKTKKE DIPRQLVYIG LYLFHILGAY VLNLNRLGLV LLVLHYFVEF LFHMSRLFYF
     SNEKYQKGFT VWALLFVLGR LLTLILCVLT VGFGLARAEN QELDLSNGNF NILAIRISVL
     ASICITQAFM MWKFINFQLR RWREHSSPQP SSQRKKTTSA KGKASRKEKE NGVNGTVTSN
     GADSPRSRKE KHS