TR43A_MOUSE
ID TR43A_MOUSE Reviewed; 445 AA.
AC Q3TL54; B9EIY7;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Tripartite motif-containing protein 43A {ECO:0000312|MGI:MGI:3645218};
GN Name=Trim43a {ECO:0000312|MGI:MGI:3645218};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:BAE26563.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAE26563.1};
RC TISSUE=Blastocyst {ECO:0000312|EMBL:BAE26563.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000312|EMBL:AAI41237.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4] {ECO:0000305}
RP IDENTIFICATION, AND DEVELOPMENTAL STAGE.
RX PubMed=19703589; DOI=10.1016/j.gep.2009.08.002;
RA Stanghellini I., Falco G., Lee S.L., Monti M., Ko M.S.;
RT "Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in
RT mouse preimplantation embryos.";
RL Gene Expr. Patterns 9:595-602(2009).
CC -!- DEVELOPMENTAL STAGE: Expression is restricted to preimplantation
CC embryos and peaks at the 8-cell to morula stage.
CC {ECO:0000269|PubMed:19703589}.
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family. {ECO:0000255}.
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DR EMBL; AK145647; BAE26563.1; -; mRNA.
DR EMBL; AK166678; BAE38938.1; -; mRNA.
DR EMBL; AC163666; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC141236; AAI41237.1; -; mRNA.
DR CCDS; CCDS23389.1; -.
DR RefSeq; NP_001030078.1; NM_001034906.2.
DR RefSeq; XP_017168975.1; XM_017313486.1.
DR AlphaFoldDB; Q3TL54; -.
DR SMR; Q3TL54; -.
DR STRING; 10090.ENSMUSP00000127527; -.
DR iPTMnet; Q3TL54; -.
DR PhosphoSitePlus; Q3TL54; -.
DR PaxDb; Q3TL54; -.
DR PRIDE; Q3TL54; -.
DR Ensembl; ENSMUST00000164661; ENSMUSP00000127527; ENSMUSG00000090693.
DR GeneID; 547109; -.
DR KEGG; mmu:547109; -.
DR UCSC; uc009qyv.1; mouse.
DR CTD; 547109; -.
DR MGI; MGI:3645218; Trim43a.
DR VEuPathDB; HostDB:ENSMUSG00000090693; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000160005; -.
DR HOGENOM; CLU_013137_0_3_1; -.
DR InParanoid; Q3TL54; -.
DR OMA; PLCEERD; -.
DR OrthoDB; 699787at2759; -.
DR PhylomeDB; Q3TL54; -.
DR TreeFam; TF338674; -.
DR BioGRID-ORCS; 547109; 2 hits in 53 CRISPR screens.
DR PRO; PR:Q3TL54; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q3TL54; protein.
DR Bgee; ENSMUSG00000090693; Expressed in morula and 29 other tissues.
DR ExpressionAtlas; Q3TL54; baseline and differential.
DR Genevisible; Q3TL54; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF00097; zf-C3HC4; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..445
FT /note="Tripartite motif-containing protein 43A"
FT /id="PRO_0000392434"
FT DOMAIN 270..445
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT ZN_FING 16..57
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 88..129
FT /note="B box-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 93
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 96
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 115
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 121
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT CONFLICT 169
FT /note="L -> LK (in Ref. 3; AAI41237)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 445 AA; 52125 MW; 808EB09ABD7DF8FA CRC64;
MESDNLQDPQ EETLTCSICQ SIFMNPVYLR CGHKFCEACL LLSQEDIKFP AYCPMCMQPF
NQEYINDISL KKQVSIVRKK RLMKYLNSKE HKCVTHKAKK MIFCDKSKIL LCHLCSDSQE
HSGHTHCSID VAVQEKMEEL LKHMDSLWRR LKIQQNYVEI ERRTTLWWLS VKLREEVIKR
VYGKQCPPLC EERDQHIECL RHQSNTTLEE LRKSEATIVH ERNQLIEVYR ELMTMSQRPY
QELLVQDLDD LFRRSKLAAK LDMPQGMIPR LHAHSIPGLT ARLNSFRVKI SFKHSIMFGY
TSVRPFDIRL LHESTSLDSA ETHRVSWGKK SFSRGKYYWE VDLKDHEQWT VGVRKDPWLR
GRSYAATPTD LFLLECLRKE DHYILITRIG GEHYIEKPVG QVGVFLDCEG GYVSFVDVAK
SSLILSYSPG TFHCAVRPFF SAVYT
