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TR43B_HUMAN
ID   TR43B_HUMAN             Reviewed;         446 AA.
AC   A6NCK2;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-OCT-2009, sequence version 3.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Tripartite motif-containing protein 43B;
GN   Name=TRIM43B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
CC   -!- SIMILARITY: Belongs to the TRIM/RBCC family. {ECO:0000305}.
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DR   EMBL; AC009237; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001157936.1; NM_001164464.1.
DR   AlphaFoldDB; A6NCK2; -.
DR   SMR; A6NCK2; -.
DR   BioGRID; 575596; 1.
DR   PhosphoSitePlus; A6NCK2; -.
DR   BioMuta; TRIM43B; -.
DR   MassIVE; A6NCK2; -.
DR   PeptideAtlas; A6NCK2; -.
DR   PRIDE; A6NCK2; -.
DR   Antibodypedia; 78260; 8 antibodies from 4 providers.
DR   DNASU; 653192; -.
DR   Ensembl; ENST00000639673.2; ENSP00000492719.1; ENSG00000144010.10.
DR   GeneID; 653192; -.
DR   KEGG; hsa:653192; -.
DR   MANE-Select; ENST00000639673.3; ENSP00000492719.1; NM_001164464.2; NP_001157936.1.
DR   CTD; 653192; -.
DR   GeneCards; TRIM43B; -.
DR   HGNC; HGNC:37146; TRIM43B.
DR   HPA; ENSG00000144010; Not detected.
DR   neXtProt; NX_A6NCK2; -.
DR   OpenTargets; ENSG00000144010; -.
DR   PharmGKB; PA165697592; -.
DR   VEuPathDB; HostDB:ENSG00000144010; -.
DR   GeneTree; ENSGT00940000160005; -.
DR   InParanoid; A6NCK2; -.
DR   OMA; ISLRAMY; -.
DR   OrthoDB; 565446at2759; -.
DR   PhylomeDB; A6NCK2; -.
DR   PathwayCommons; A6NCK2; -.
DR   SignaLink; A6NCK2; -.
DR   BioGRID-ORCS; 653192; 5 hits in 188 CRISPR screens.
DR   GenomeRNAi; 653192; -.
DR   Pharos; A6NCK2; Tdark.
DR   PRO; PR:A6NCK2; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; A6NCK2; protein.
DR   Bgee; ENSG00000144010; Expressed in ganglionic eminence and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR   GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR   Gene3D; 2.60.120.920; -; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR003879; Butyrophylin_SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR000315; Znf_B-box.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF00622; SPRY; 1.
DR   PRINTS; PR01407; BUTYPHLNCDUF.
DR   SMART; SM00336; BBOX; 1.
DR   SMART; SM00184; RING; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50119; ZF_BBOX; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..446
FT                   /note="Tripartite motif-containing protein 43B"
FT                   /id="PRO_0000318857"
FT   DOMAIN          269..446
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT   ZN_FING         15..56
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   ZN_FING         88..129
FT                   /note="B box-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   COILED          129..158
FT                   /evidence="ECO:0000255"
FT   COILED          190..220
FT                   /evidence="ECO:0000255"
FT   BINDING         93
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   BINDING         96
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   BINDING         115
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   BINDING         121
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
SQ   SEQUENCE   446 AA;  52310 MW;  FACBEB71FD9F76F4 CRC64;
     MDSDFSHAFQ KELTCVICLN YLVDPVTICC GHSFCRPCLC LSWEEAQSPA NCPACREPSP
     KMDFKTNILL KNLVTIARKA SLWQFLSSEK QICGTHRQTK KMFCDMDKSL LCLLCSNSQE
     HGAHKHYPIE EAAEEDREKL LKQMRILWKK IQENQRNLYE ERRTAFLLRG DVVLRAQMIR
     NEYRKLHPVL HKEEKQHLER LNKEYQEIFQ QLQRSWVKMD QKSKHLKEMY QELMEMCHKP
     EVELLQDLGD IVARSESVLL HMPQPVNPEL TAGPITGLVY RLNRFRVEIS FHFEVTNHNI
     RLFEDVRSWM FRRGPLNSDR SDYFAAWGAR VFSFGKHYWE LDVDNSCDWA LGVCNNSWIR
     KNSTMVNSED IFLLLCLKVD NHFNLLTTSP VFPHYIEKPL GRVGVFLDFE SGSVSFLNVT
     KSSLIWSYPA GSLTFPVRPF FYTGHR
 
 
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