TR43B_MOUSE
ID TR43B_MOUSE Reviewed; 445 AA.
AC P86448;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 23-MAR-2010, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=Tripartite motif-containing protein 43B {ECO:0000312|MGI:MGI:3648996};
GN Name=Trim43b {ECO:0000312|MGI:MGI:3648996};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000305}
RP IDENTIFICATION, AND DEVELOPMENTAL STAGE.
RX PubMed=19703589; DOI=10.1016/j.gep.2009.08.002;
RA Stanghellini I., Falco G., Lee S.L., Monti M., Ko M.S.;
RT "Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in
RT mouse preimplantation embryos.";
RL Gene Expr. Patterns 9:595-602(2009).
CC -!- DEVELOPMENTAL STAGE: Expression is restricted to preimplantation
CC embryos and peaks at the 8-cell to morula stage.
CC {ECO:0000269|PubMed:19703589}.
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family. {ECO:0000255}.
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DR EMBL; CT030686; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS52884.1; -.
DR RefSeq; NP_001164355.1; NM_001170884.1.
DR AlphaFoldDB; P86448; -.
DR SMR; P86448; -.
DR STRING; 10090.ENSMUSP00000126594; -.
DR iPTMnet; P86448; -.
DR PhosphoSitePlus; P86448; -.
DR PaxDb; P86448; -.
DR PRIDE; P86448; -.
DR Ensembl; ENSMUST00000167113; ENSMUSP00000126594; ENSMUSG00000079162.
DR GeneID; 666747; -.
DR KEGG; mmu:666747; -.
DR UCSC; uc012gyc.1; mouse.
DR CTD; 653192; -.
DR MGI; MGI:3648996; Trim43b.
DR VEuPathDB; HostDB:ENSMUSG00000079162; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000160005; -.
DR HOGENOM; CLU_013137_0_3_1; -.
DR InParanoid; P86448; -.
DR OMA; LHIRTED; -.
DR OrthoDB; 699787at2759; -.
DR PhylomeDB; P86448; -.
DR TreeFam; TF338674; -.
DR BioGRID-ORCS; 666747; 1 hit in 40 CRISPR screens.
DR PRO; PR:P86448; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; P86448; protein.
DR Bgee; ENSMUSG00000079162; Expressed in morula and 17 other tissues.
DR ExpressionAtlas; P86448; baseline and differential.
DR Genevisible; P86448; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0019901; F:protein kinase binding; ISO:MGI.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF00097; zf-C3HC4; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..445
FT /note="Tripartite motif-containing protein 43B"
FT /id="PRO_0000392435"
FT DOMAIN 271..445
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT ZN_FING 16..57
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 88..129
FT /note="B box-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 93
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 96
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 115
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 121
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
SQ SEQUENCE 445 AA; 52238 MW; 176C259A5E396094 CRC64;
MESDNLQDPQ EETLTCSICQ GIFMNPVYLK CGHKFCEACL LLFQEDIKFP AYCPMCMQPF
NQEYINDISL KKQVSIVRKK RLMEYLNSEE HKCVTHKAKK MIFCDKSKIL LCHLCSDSQE
HSGHTHCSID VAVQEKMEEL LKHMDSLWRR LKIQQNYVEK ERRTTLWWLK SMKLREEVIK
RVYGKQCPPL SEERDQHIEC LRHQSNTTLE ELRKSEATIV HERNQLTEVY RELMTMSQRP
YQELLVQDLD DLFRRSKLAA KLDMPQGMIP RLRAHSIPGL TARLNSFRVK ISFKHSIMFG
YTSLRPFDIR LLHESTSLDS AETHRVSWGK KSFSRGKYYW EVDLKDYRRW TVGVCKDPWL
RGRSYVATPT DLFLECLRKD DHYILITRIG GEHYIEKPVG QVGVFLDCEG GYVSFVDVAK
SSLILSYSPG TFHCAVRPFF SAVYT
