TR43C_MOUSE
ID TR43C_MOUSE Reviewed; 446 AA.
AC P86449;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 23-MAR-2010, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Tripartite motif-containing protein 43C {ECO:0000312|MGI:MGI:3647365};
GN Name=Trim43c {ECO:0000312|MGI:MGI:3647365};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000305}
RP IDENTIFICATION, AND DEVELOPMENTAL STAGE.
RX PubMed=19703589; DOI=10.1016/j.gep.2009.08.002;
RA Stanghellini I., Falco G., Lee S.L., Monti M., Ko M.S.;
RT "Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in
RT mouse preimplantation embryos.";
RL Gene Expr. Patterns 9:595-602(2009).
CC -!- DEVELOPMENTAL STAGE: Expression is restricted to preimplantation
CC embryos and peaks at the 8-cell to morula stage.
CC {ECO:0000269|PubMed:19703589}.
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family. {ECO:0000255}.
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DR EMBL; CT030259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CT030651; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS52883.1; -.
DR RefSeq; NP_001171329.1; NM_001177858.1.
DR RefSeq; XP_006511421.1; XM_006511358.3.
DR AlphaFoldDB; P86449; -.
DR SMR; P86449; -.
DR STRING; 10090.ENSMUSP00000129255; -.
DR iPTMnet; P86449; -.
DR PhosphoSitePlus; P86449; -.
DR PaxDb; P86449; -.
DR PRIDE; P86449; -.
DR Ensembl; ENSMUST00000163255; ENSMUSP00000129255; ENSMUSG00000067399.
DR GeneID; 666731; -.
DR KEGG; mmu:666731; -.
DR UCSC; uc012gyb.1; mouse.
DR CTD; 666731; -.
DR MGI; MGI:3647365; Trim43c.
DR VEuPathDB; HostDB:ENSMUSG00000067399; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000160005; -.
DR HOGENOM; CLU_013137_0_3_1; -.
DR InParanoid; P86449; -.
DR OMA; ISLRAMY; -.
DR OrthoDB; 565446at2759; -.
DR PhylomeDB; P86449; -.
DR TreeFam; TF338674; -.
DR BioGRID-ORCS; 666731; 2 hits in 72 CRISPR screens.
DR PRO; PR:P86449; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; P86449; protein.
DR Bgee; ENSMUSG00000067399; Expressed in morula and 27 other tissues.
DR ExpressionAtlas; P86449; baseline and differential.
DR Genevisible; P86449; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0019901; F:protein kinase binding; ISO:MGI.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF00097; zf-C3HC4; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..446
FT /note="Tripartite motif-containing protein 43C"
FT /id="PRO_0000392436"
FT DOMAIN 271..446
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT ZN_FING 16..57
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 88..129
FT /note="B box-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 93
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 96
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 115
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 121
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
SQ SEQUENCE 446 AA; 52533 MW; B1B650222AF485C7 CRC64;
MESDNLQDPQ EETLTCSICQ GIFMDPVYLR CGHKFCETCL LLFQEDIKFP AYCPTCRQPC
NQRYINDISL KKQVFIVRKK RLMEYLNSEE HKCVTHKAKK MIFCDKSKIL LCHLCSDSQE
HSGHTHCSID VAVQEKMEEL LKHMDSLWQR LKIQQNYVEK ERRMTLWWLK SVKLREEVIK
RVYGKQCPPL SEERDQHIEC LRHQSNTTLE ELRKSEATIV HERNQLTEVY QELMTMSQRP
YQELLVQDLD DLFRRSKLAA KVDMPQGMIP RLRAHSIPGL TARLNSFRVK ISFKHSIMFG
YNSVRPFDIR LLHESTSLDS AKTHRVSWGK KSFSRGKYYW EVDLKDYRRW TVGVCKDPWL
RGRSYVVTPT DIFLLECLRN KDHYILITRI GREHYIEKPV GQVGVFLDCE GGYVSFVDVA
KSSLILSYSP GTFHCAVRPF FFAAYT
