ID   TR443_MIMIV             Reviewed;         164 AA.
AC   Q5UQN5;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   29-SEP-2021, entry version 80.
DE   RecName: Full=Thioredoxin domain-containing protein R443;
GN   OrderedLocusNames=MIMI_R443;
OS   Acanthamoeba polyphaga mimivirus (APMV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Imitervirales; Mimiviridae; Mimivirus.
OX   NCBI_TaxID=212035;
OH   NCBI_TaxID=5757; Acanthamoeba polyphaga (Amoeba).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rowbotham-Bradford;
RX   PubMed=15486256; DOI=10.1126/science.1101485;
RA   Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H.,
RA   La Scola B., Susan M., Claverie J.-M.;
RT   "The 1.2-megabase genome sequence of Mimivirus.";
RL   Science 306:1344-1350(2004).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], AND SUBCELLULAR
RP   LOCATION.
RX   PubMed=16971431; DOI=10.1128/jvi.00940-06;
RA   Renesto P., Abergel C., Decloquement P., Moinier D., Azza S., Ogata H.,
RA   Fourquet P., Gorvel J.-P., Claverie J.-M., Raoult D.;
RT   "Mimivirus giant particles incorporate a large fraction of anonymous and
RT   unique gene products.";
RL   J. Virol. 80:11678-11685(2006).
CC   -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}. Virion {ECO:0000269|PubMed:16971431}.
CC   -!- SIMILARITY: Belongs to the thioredoxin family. {ECO:0000305}.
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DR   EMBL; AY653733; AAV50709.1; -; Genomic_DNA.
DR   RefSeq; YP_003986950.1; NC_014649.1.
DR   SMR; Q5UQN5; -.
DR   GeneID; 9925067; -.
DR   KEGG; vg:9925067; -.
DR   Proteomes; UP000001134; Genome.
DR   GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   Pfam; PF00085; Thioredoxin; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond; Host membrane; Membrane; Redox-active center;
KW   Reference proteome; Transmembrane; Transmembrane helix; Virion.
FT   CHAIN           1..164
FT                   /note="Thioredoxin domain-containing protein R443"
FT                   /id="PRO_0000243952"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          36..163
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT   DISULFID        84..87
FT                   /note="Redox-active"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
SQ   SEQUENCE   164 AA;  19438 MW;  0324D612D858A690 CRC64;
     MRKLSWQHIV LIVLAIILIL WIISLLLCRK PVRPTYQVPI IQPMQVIQPH QNDIDPAWQT
     TYSPNNTDNQ NQQYVLYYFN NPSCPHCKNF SSTWDMLKNN FRSINNLSLK EISTDKQENE
     HLVFYYNIRR VPTIILVTPD KNLEYSGNKS LEDLTQFIRS NMNQ