TR49B_HUMAN
ID TR49B_HUMAN Reviewed; 452 AA.
AC A6NDI0;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Putative tripartite motif-containing protein 49B;
DE AltName: Full=RING finger protein 18B;
GN Name=TRIM49B; Synonyms=RNF18B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 39-223.
RX PubMed=22144910; DOI=10.1371/journal.pgen.1002388;
RA Han K., Lou D.I., Sawyer S.L.;
RT "Identification of a genomic reservoir for new TRIM genes in primate
RT genomes.";
RL PLoS Genet. 7:E1002388-E1002388(2011).
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family. {ECO:0000305}.
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DR EMBL; AC084851; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; JF968463; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS55762.1; -.
DR RefSeq; NP_001193555.1; NM_001206626.1.
DR AlphaFoldDB; A6NDI0; -.
DR SMR; A6NDI0; -.
DR STRING; 9606.ENSP00000481457; -.
DR iPTMnet; A6NDI0; -.
DR PhosphoSitePlus; A6NDI0; -.
DR BioMuta; TRIM49B; -.
DR jPOST; A6NDI0; -.
DR MassIVE; A6NDI0; -.
DR PaxDb; A6NDI0; -.
DR PeptideAtlas; A6NDI0; -.
DR PRIDE; A6NDI0; -.
DR Antibodypedia; 77057; 3 antibodies from 3 providers.
DR DNASU; 283116; -.
DR Ensembl; ENST00000332682.9; ENSP00000330216.7; ENSG00000182053.13.
DR Ensembl; ENST00000622138.4; ENSP00000481457.1; ENSG00000182053.13.
DR GeneID; 283116; -.
DR KEGG; hsa:283116; -.
DR MANE-Select; ENST00000332682.9; ENSP00000330216.7; NM_001206626.2; NP_001193555.1.
DR UCSC; uc021qix.2; human.
DR CTD; 283116; -.
DR DisGeNET; 283116; -.
DR GeneCards; TRIM49B; -.
DR HGNC; HGNC:42955; TRIM49B.
DR HPA; ENSG00000182053; Not detected.
DR neXtProt; NX_A6NDI0; -.
DR OpenTargets; ENSG00000182053; -.
DR VEuPathDB; HostDB:ENSG00000182053; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000165665; -.
DR HOGENOM; CLU_013137_0_3_1; -.
DR InParanoid; A6NDI0; -.
DR OMA; NFFCEVI; -.
DR OrthoDB; 565446at2759; -.
DR PhylomeDB; A6NDI0; -.
DR TreeFam; TF338674; -.
DR BioGRID-ORCS; 283116; 11 hits in 1007 CRISPR screens.
DR GenomeRNAi; 283116; -.
DR Pharos; A6NDI0; Tdark.
DR PRO; PR:A6NDI0; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; A6NDI0; protein.
DR Bgee; ENSG00000182053; Expressed in muscle tissue and 6 other tissues.
DR Genevisible; A6NDI0; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..452
FT /note="Putative tripartite motif-containing protein 49B"
FT /id="PRO_0000328997"
FT DOMAIN 269..452
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT ZN_FING 15..56
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 88..129
FT /note="B box-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 93
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 96
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 115
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 121
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT VARIANT 398
FT /note="L -> M (in dbSNP:rs2696914)"
FT /id="VAR_042601"
SQ SEQUENCE 452 AA; 52747 MW; F6A703FD7A1E10BE CRC64;
MNSGILQVFQ RELICPICMN YFIDPVTIDC GHSFCRPCFY LNWKDSPFLV QCSECTKSTG
QINLKTNIHF KKMASLARKV SLWLFLSSEE QMCGTHRETK KMFCEVDRSL LCLLCSSSQE
HRDHRHCPIE SAAEEHQEKL LQKMQSLWEK ACENHRNLNV ETTRTRCWKD YVNLRLEAIR
AEYQKMPAFH HEEEKHNLEM LKKKGKDIFH RLHLSKAKMA HRREILRGMY EELNEMCHKP
DVELLQAFGD ILHRSESVLL HMPQPLNPEL SAGPITGLRD RLNQFRVHIT LHHEEANSDI
FLCEILRSMC IGCDHQDVPY FTATPRSFLA WGAQTFTSGK YYWEVHVGDS WNWAFGVCNM
YWKEKNQNEK IDGEDGLFLL GCVKNDIQRS LFTTSPLLLQ YIPRPTSRVG LFLDCEAKTV
SFVDVNQSSL IYTIPNCSFS PPLRPIFCCI HF
