TR49C_HUMAN
ID TR49C_HUMAN Reviewed; 452 AA.
AC P0CI26; A0AVR7; A0AVR9; Q6DJV1; Q9NS80;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-NOV-2010, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Tripartite motif-containing protein 49C;
DE AltName: Full=Tripartite motif-containing protein 49-like protein 2;
GN Name=TRIM49C; Synonyms=TRIM49L2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC P0CI26; P61024: CKS1B; NbExp=3; IntAct=EBI-12889036, EBI-456371;
CC P0CI26; P0CW20: LIMS4; NbExp=3; IntAct=EBI-12889036, EBI-10196832;
CC P0CI26; Q9H8M7: MINDY3; NbExp=3; IntAct=EBI-12889036, EBI-724928;
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DR EMBL; AP004607; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC126470; AAI26471.1; -; mRNA.
DR CCDS; CCDS53694.1; -.
DR RefSeq; NP_001182163.1; NM_001195234.1.
DR AlphaFoldDB; P0CI26; -.
DR SMR; P0CI26; -.
DR BioGRID; 568114; 4.
DR IntAct; P0CI26; 3.
DR STRING; 9606.ENSP00000388299; -.
DR iPTMnet; P0CI26; -.
DR PhosphoSitePlus; P0CI26; -.
DR BioMuta; TRIM49C; -.
DR DMDM; 310947306; -.
DR MassIVE; P0CI26; -.
DR PaxDb; P0CI26; -.
DR PeptideAtlas; P0CI26; -.
DR PRIDE; P0CI26; -.
DR Antibodypedia; 50557; 14 antibodies from 7 providers.
DR DNASU; 642612; -.
DR Ensembl; ENST00000448984.1; ENSP00000388299.1; ENSG00000204449.3.
DR GeneID; 642612; -.
DR KEGG; hsa:642612; -.
DR MANE-Select; ENST00000448984.1; ENSP00000388299.1; NM_001195234.1; NP_001182163.1.
DR UCSC; uc010rua.2; human.
DR CTD; 642612; -.
DR GeneCards; TRIM49C; -.
DR HGNC; HGNC:38877; TRIM49C.
DR HPA; ENSG00000204449; Not detected.
DR neXtProt; NX_P0CI26; -.
DR OpenTargets; ENSG00000204449; -.
DR VEuPathDB; HostDB:ENSG00000204449; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000165665; -.
DR HOGENOM; CLU_013137_0_3_1; -.
DR InParanoid; P0CI26; -.
DR OMA; QWALGIY; -.
DR OrthoDB; 565446at2759; -.
DR PhylomeDB; P0CI26; -.
DR TreeFam; TF338674; -.
DR PathwayCommons; P0CI26; -.
DR SignaLink; P0CI26; -.
DR BioGRID-ORCS; 642612; 179 hits in 601 CRISPR screens.
DR GenomeRNAi; 642612; -.
DR Pharos; P0CI26; Tdark.
DR PRO; PR:P0CI26; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; P0CI26; protein.
DR Bgee; ENSG00000204449; Expressed in cerebral cortex and 4 other tissues.
DR Genevisible; P0CI26; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 1: Evidence at protein level;
KW Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..452
FT /note="Tripartite motif-containing protein 49C"
FT /id="PRO_0000399992"
FT DOMAIN 269..452
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT ZN_FING 15..56
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 88..129
FT /note="B box-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 93
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 96
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 115
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 121
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
SQ SEQUENCE 452 AA; 52933 MW; 50895E81A46DEA3F CRC64;
MNSGILQVFQ GELICPLCMN YFIDPVTIDC GHSFCRPCFY LNWQDIPFLV QCSECTKSTE
QINLKTNIHL KKMASLARKV SLWLFLSSEE QMCGTHRETK KIFCEVDRSL LCLLCSSSQE
HRYHRHRPIE WAAEEHREKL LQKMQSLWEK ACENHRNLNV ETTRTRCWKD YVNLRLEAIR
AEYQKMPAFH HEEEKHNLEM LKKKGKEIFH RLHLSKAKMA HRMEILRGMY EELNEMCHKP
DVELLQAFGD ILHRSESVLL HMPQPLNPEL SAGPITGLRD RLNQFRVHIT LHHEEANSDI
FLYEILRSMC IGCDHQDVPY FTATPRSFLA WGVQTFTSGK YYWEVHVGDS WNWAFGVCNM
YRKEKNQNEK IDGKEGLFLL GCIKNDIQCS LFTTSPLMLQ YIPKPTSRVG LFLDCEAKTV
SFVDVNQSSL IYTIPNCSFS PPLRPIFCCI HF
