TR49D_HUMAN
ID TR49D_HUMAN Reviewed; 452 AA.
AC C9J1S8; I1YAP9;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 03-NOV-2009, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Tripartite motif-containing protein 49D {ECO:0000305};
DE AltName: Full=Tripartite motif-containing protein 49-like protein;
DE AltName: Full=Tripartite motif-containing protein 49D1 {ECO:0000312|HGNC:HGNC:43973};
DE AltName: Full=Tripartite motif-containing protein 49D2 {ECO:0000312|HGNC:HGNC:37217};
GN Name=TRIM49D1 {ECO:0000312|HGNC:HGNC:43973}; Synonyms=TRIM49L, TRIM49L1;
GN and
GN Name=TRIM49D2 {ECO:0000312|HGNC:HGNC:37217}; Synonyms=TRIM49D2P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 155-229.
RA Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.;
RT "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in
RT human.";
RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 222-303.
RX PubMed=22144910; DOI=10.1371/journal.pgen.1002388;
RA Han K., Lou D.I., Sawyer S.L.;
RT "Identification of a genomic reservoir for new TRIM genes in primate
RT genomes.";
RL PLoS Genet. 7:E1002388-E1002388(2011).
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family. {ECO:0000305}.
CC -!- CAUTION: The two loci are in opposite orientation. {ECO:0000305}.
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DR EMBL; AP004607; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DW009626; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; JF968447; AFI99090.1; -; mRNA.
DR EMBL; JF968448; AFI99091.1; -; mRNA.
DR CCDS; CCDS60930.1; -.
DR RefSeq; NP_001098992.1; NM_001105522.1.
DR RefSeq; NP_001193556.1; NM_001206627.1.
DR RefSeq; XP_011541118.1; XM_011542816.2.
DR AlphaFoldDB; C9J1S8; -.
DR SMR; C9J1S8; -.
DR iPTMnet; C9J1S8; -.
DR PhosphoSitePlus; C9J1S8; -.
DR BioMuta; TRIM49D2; -.
DR MassIVE; C9J1S8; -.
DR PeptideAtlas; C9J1S8; -.
DR PRIDE; C9J1S8; -.
DR DNASU; 399939; -.
DR Ensembl; ENST00000420869.3; ENSP00000474678.1; ENSG00000223417.9.
DR Ensembl; ENST00000526396.3; ENSP00000485325.1; ENSG00000233802.8.
DR Ensembl; ENST00000530311.6; ENSP00000474850.1; ENSG00000223417.9.
DR Ensembl; ENST00000623787.3; ENSP00000485097.1; ENSG00000233802.8.
DR GeneID; 399939; -.
DR GeneID; 729384; -.
DR KEGG; hsa:399939; -.
DR KEGG; hsa:729384; -.
DR MANE-Select; ENST00000420869.3; ENSP00000474678.1; NM_001384911.1; NP_001371840.1.
DR MANE-Select; ENST00000623787.3; ENSP00000485097.1; NM_001105522.1; NP_001098992.1.
DR UCSC; uc009yvu.4; human.
DR CTD; 399939; -.
DR CTD; 729384; -.
DR GeneCards; TRIM49D1; -.
DR GeneCards; TRIM49D2; -.
DR HGNC; HGNC:43973; TRIM49D1.
DR HGNC; HGNC:37217; TRIM49D2.
DR HPA; ENSG00000223417; Not detected.
DR HPA; ENSG00000233802; Not detected.
DR neXtProt; NX_C9J1S8; -.
DR OpenTargets; ENSG00000223417; -.
DR PharmGKB; PA165543723; -.
DR VEuPathDB; HostDB:ENSG00000223417; -.
DR VEuPathDB; HostDB:ENSG00000233802; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000163213; -.
DR HOGENOM; CLU_013137_0_3_1; -.
DR InParanoid; C9J1S8; -.
DR OMA; VICEKHQ; -.
DR OrthoDB; 565446at2759; -.
DR PhylomeDB; C9J1S8; -.
DR BioGRID-ORCS; 399939; 284 hits in 988 CRISPR screens.
DR BioGRID-ORCS; 729384; 13 hits in 115 CRISPR screens.
DR ChiTaRS; TRIM49D2; human.
DR Pharos; C9J1S8; Tdark.
DR PRO; PR:C9J1S8; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; C9J1S8; protein.
DR Bgee; ENSG00000223417; Expressed in monocyte and 9 other tissues.
DR ExpressionAtlas; C9J1S8; baseline and differential.
DR Genevisible; C9J1S8; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF00622; SPRY; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..452
FT /note="Tripartite motif-containing protein 49D"
FT /id="PRO_0000395402"
FT DOMAIN 269..452
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT ZN_FING 15..56
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 88..129
FT /note="B box-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 93
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 96
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 115
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 121
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT CONFLICT 207
FT /note="D -> E (in Ref. 2; DW009626)"
FT /evidence="ECO:0000305"
FT CONFLICT 213
FT /note="H -> K (in Ref. 2; DW009626)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 452 AA; 52496 MW; 68364723E20D0DA5 CRC64;
MNSGISQVFQ RELTCPICLN YFIDPVTIDC GHSFCRPCFY LNWQDIPILT QCFECLKTTQ
QRNLKTNIRL KKMASRARKA SLWLFLSSEE QMCGTHRETK KIFCEVDRSL LCLLCSSSLE
HRYHRHCPAE WAAEEHREKL LKKMQSLWEK VCENQRNLNV ETTRISHWKD YVNVRLEAIR
AEYQKMPAFH HEEEKHNLEM LKKKGKDIFH RLHLSKAKMA HRREILRGTY AELMKMCHKP
DVELLQAFGD ILHRSESVLL HMPQPLNLEL RAGPITGLRD RLNQFRVDIT LPHNEANSHI
FRRGDLRSIC IGCDRQNAPH ITATPTSFLA WGAQTFTSGK YYWEVHVGDS WNWAFGVCNK
YWKGTNQNGN IHGEEGLFSL GCVKNDIQCS LFTTSPLTLQ YVPRPTNHVG LFLDCEARTV
SFVDVNQSSP IHTIPNCSFS PPLRPIFCCV HL
