ID   TR51G_HUMAN             Reviewed;         452 AA.
AC   A0A3B3IT33;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   05-DEC-2018, sequence version 1.
DT   03-AUG-2022, entry version 19.
DE   RecName: Full=Putative tripartite motif-containing protein 51G {ECO:0000305};
DE   AltName: Full=Tripartite motif-containing 51G pseudogene {ECO:0000312|HGNC:HGNC:43972};
GN   Name=TRIM51G {ECO:0000312|HGNC:HGNC:43972};
GN   Synonyms=TRIM51GP {ECO:0000312|HGNC:HGNC:43972};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
CC   -!- SIMILARITY: Belongs to the TRIM/RBCC family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AC027369; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A3B3IT33; -.
DR   SMR; A0A3B3IT33; -.
DR   PeptideAtlas; A0A3B3IT33; -.
DR   Ensembl; ENST00000534741.2; ENSP00000497050.1; ENSG00000220948.5.
DR   Ensembl; ENST00000649162.1; ENSP00000497716.1; ENSG00000220948.5.
DR   MANE-Select; ENST00000534741.3; ENSP00000497050.1; NM_001396075.1; NP_001383004.1.
DR   GeneCards; TRIM51GP; -.
DR   HGNC; HGNC:43972; TRIM51G.
DR   OpenTargets; ENSG00000220948; -.
DR   VEuPathDB; HostDB:ENSG00000220948; -.
DR   GeneTree; ENSGT00940000163419; -.
DR   OMA; PVICCSH; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR   GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR   Gene3D; 2.60.120.920; -; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR003879; Butyrophylin_SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR000315; Znf_B-box.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF00622; SPRY; 1.
DR   PRINTS; PR01407; BUTYPHLNCDUF.
DR   SMART; SM00336; BBOX; 1.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50119; ZF_BBOX; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   5: Uncertain;
KW   Coiled coil; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..452
FT                   /note="Putative tripartite motif-containing protein 51G"
FT                   /id="PRO_0000454707"
FT   DOMAIN          269..452
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT   ZN_FING         15..56
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   ZN_FING         88..129
FT                   /note="B box-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   BINDING         93
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   BINDING         96
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   BINDING         115
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT   BINDING         121
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
SQ   SEQUENCE   452 AA;  53047 MW;  C921DCF85128A84A CRC64;
     MNSGILQVFQ RELICPICMN YFIDPVTIDC GHSFCRPCFY LNWQDMAVLA QCSKCKKTTR
     QRNLKTNICL KNMASIARKA SLRQFLSSEE QICGTHRETK EMFCEVDKSL LCLLCSNSQE
     HRNHRHCPTE WAAEERREEL LRKMQSLWRK MCENHRNLNM ATNRIRCWKD YVSLRIEAIR
     AEYHKMVAFF HEEEQRHLER LQKEGEDIFQ QLNESKARME HSRELLRGMY EDLRQMCHKA
     VVELFQSFGD ILQRYESLLL QVSEPVNPEF SAGPIIGLMD RLKGFRVYLT LQHARASSHI
     FLHGDLRSMK VGCDPQHDPN ITDKSECFLQ WGADFFISGK FYWEFNMGHS WNWAFGVCNN
     YWKEKRQNDM IDGEVGLFLL GCVKEDTHCS LFTTSPLVMQ YVPRPTDTVG LFLDCEGRTV
     SFVDVDRSSL IYTIPNCSFS PPLWPIICCS HF