TR64B_HUMAN
ID TR64B_HUMAN Reviewed; 449 AA.
AC A6NI03;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 3.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Putative tripartite motif-containing protein 64B;
GN Name=TRIM64B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AP005435; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS53693.1; -.
DR RefSeq; NP_001157869.1; NM_001164397.1.
DR RefSeq; XP_011541256.1; XM_011542954.2.
DR AlphaFoldDB; A6NI03; -.
DR SMR; A6NI03; -.
DR iPTMnet; A6NI03; -.
DR PhosphoSitePlus; A6NI03; -.
DR BioMuta; TRIM64B; -.
DR EPD; A6NI03; -.
DR PaxDb; A6NI03; -.
DR PeptideAtlas; A6NI03; -.
DR PRIDE; A6NI03; -.
DR Antibodypedia; 67810; 5 antibodies from 5 providers.
DR DNASU; 642446; -.
DR Ensembl; ENST00000329862.6; ENSP00000332969.6; ENSG00000189253.7.
DR GeneID; 642446; -.
DR KEGG; hsa:642446; -.
DR MANE-Select; ENST00000329862.7; ENSP00000332969.6; NM_001164397.3; NP_001157869.1.
DR UCSC; uc021qoo.2; human.
DR CTD; 642446; -.
DR GeneCards; TRIM64B; -.
DR HGNC; HGNC:37147; TRIM64B.
DR HPA; ENSG00000189253; Tissue enriched (placenta).
DR neXtProt; NX_A6NI03; -.
DR OpenTargets; ENSG00000189253; -.
DR PharmGKB; PA165543724; -.
DR VEuPathDB; HostDB:ENSG00000189253; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000163440; -.
DR HOGENOM; CLU_013137_0_3_1; -.
DR InParanoid; A6NI03; -.
DR OMA; SICMNYY; -.
DR OrthoDB; 704031at2759; -.
DR PhylomeDB; A6NI03; -.
DR TreeFam; TF338674; -.
DR BioGRID-ORCS; 642446; 22 hits in 1016 CRISPR screens.
DR GenomeRNAi; 642446; -.
DR Pharos; A6NI03; Tdark.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; A6NI03; protein.
DR Bgee; ENSG00000189253; Expressed in placenta and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 5: Uncertain;
KW Coiled coil; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..449
FT /note="Putative tripartite motif-containing protein 64B"
FT /id="PRO_0000340247"
FT DOMAIN 268..449
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT ZN_FING 15..56
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 87..128
FT /note="B box-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT COILED 189..225
FT /evidence="ECO:0000255"
FT BINDING 92
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 95
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 114
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 120
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
SQ SEQUENCE 449 AA; 51557 MW; AF0D870C0130A02E CRC64;
MDSDDLQVFQ NELICCICVN YFIDPVTIDC GHSFCRPCLC LCSEEGRAPM RCPSCRKTSE
KPNFNTNLVL KKLSSLARQT RPQNINSSDN ICVLHEETKE LFCEADKRLL CGPCSESPEH
MAHSHSPIGW AAEECREKLI KEMDYLWEIN QETRNNLNQE TSTFHSLKDY VSVRKRIITI
QYQKMPIFLD EEEQRHLQAL EREAEELFQQ LQDSQVRMTQ HLERMKDMYR ELWETCHMPD
VVLLQDVRNV SARTDLAQMQ KPQPVNPELT SWCITGVLDM LNNFRVDSAL STEMIPCYIS
LSEDVRYVIF GDDHLSAPTD PQGVDSFAVW GAQAFTSGKH YWEVDVTLSS NWILGVCRDS
RTADANFVID SDERFFLISS KRSNHYSLST NSPPLIQYVQ RPLGRVGVFL DYDNGSVSFF
DVSKGSLIYG FPPSSFSSPL RPFFCFGCT
