TR64C_HUMAN
ID TR64C_HUMAN Reviewed; 450 AA.
AC A6NLI5; A0A087WYH8;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 4.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Tripartite motif-containing protein 64C;
GN Name=TRIM64C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
CC -!- SIMILARITY: Belongs to the TRIM/RBCC family. {ECO:0000305}.
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DR EMBL; AC084851; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS73287.1; -.
DR RefSeq; NP_001193560.1; NM_001206631.1.
DR AlphaFoldDB; A6NLI5; -.
DR SMR; A6NLI5; -.
DR IntAct; A6NLI5; 1.
DR BioMuta; TRIM64C; -.
DR PaxDb; A6NLI5; -.
DR PeptideAtlas; A6NLI5; -.
DR PRIDE; A6NLI5; -.
DR ProteomicsDB; 1479; -.
DR Antibodypedia; 63167; 2 antibodies from 2 providers.
DR DNASU; 646754; -.
DR Ensembl; ENST00000617704.1; ENSP00000481815.1; ENSG00000214891.9.
DR GeneID; 646754; -.
DR KEGG; hsa:646754; -.
DR MANE-Select; ENST00000617704.1; ENSP00000481815.1; NM_001206631.1; NP_001193560.1.
DR CTD; 646754; -.
DR GeneCards; TRIM64C; -.
DR HGNC; HGNC:37148; TRIM64C.
DR HPA; ENSG00000214891; Not detected.
DR neXtProt; NX_A6NLI5; -.
DR VEuPathDB; HostDB:ENSG00000214891; -.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000163440; -.
DR InParanoid; A6NLI5; -.
DR OMA; RELTGMC; -.
DR OrthoDB; 704031at2759; -.
DR PhylomeDB; A6NLI5; -.
DR PathwayCommons; A6NLI5; -.
DR SignaLink; A6NLI5; -.
DR BioGRID-ORCS; 646754; 4 hits in 247 CRISPR screens.
DR GenomeRNAi; 646754; -.
DR Pharos; A6NLI5; Tdark.
DR PRO; PR:A6NLI5; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; A6NLI5; protein.
DR Bgee; ENSG00000214891; Expressed in multicellular organism and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF00622; SPRY; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Coiled coil; Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..450
FT /note="Tripartite motif-containing protein 64C"
FT /id="PRO_0000340248"
FT DOMAIN 269..450
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT ZN_FING 15..56
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 87..128
FT /note="B box-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT COILED 191..218
FT /evidence="ECO:0000255"
FT BINDING 92
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 95
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 114
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 120
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
SQ SEQUENCE 450 AA; 51540 MW; 8541F4CEAC0D1744 CRC64;
MDSDTLRVFQ NELICCICVN YFIDPVTTDC VHSFCRPCLC LCSEEGRAPM RCPLCRKISE
KPNFNTNVAL KKLASLARQT RPQNINSSDN ICVLHEETKE LFCEADKRLL CGPCSESPEH
MAHSHSPIGW AAEECRVQKL IKEMDYLWKI NQETQNNLNQ ETSKFCSLVD YVSLRKVIIT
IQYQKMHIFL DEEEQRHLQA LEREAKELFQ QLQDSQVRMT QHLEGMKDMY RELWETYHMP
DVELLQDVGN ISARTDLAQM PKPQPVNPEL TSWCITGVLD MLNNFRVDNA LSTEMTPCYI
SLSEDVRRVI FGDDHRSAPM DPQGVESFAV WCAQAFTSGK HYWEVDVTHS SNWILGVCRD
SRTADTNIVI DSDKTFFSIS SKTSNHYSLS TNSPPLIQYV QRPLGWVGVF LDYDNGSVSF
FDVSKGSLIY GFPPSSFSSP LRPFFCFGCT
