TRA1_DICDI
ID TRA1_DICDI Reviewed; 4582 AA.
AC Q54T85;
DT 26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 2.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Probable transcription-associated protein 1;
GN Name=tra1; ORFNames=DDB_G0281947;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16596165; DOI=10.1371/journal.pgen.0020038;
RA Goldberg J.M., Manning G., Liu A., Fey P., Pilcher K.E., Xu Y., Smith J.L.;
RT "The dictyostelium kinome -- analysis of the protein kinases from a simple
RT model organism.";
RL PLoS Genet. 2:E38-E38(2006).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. TRA1 subfamily.
CC {ECO:0000305}.
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DR EMBL; AAFI02000043; EAL66533.2; -; Genomic_DNA.
DR RefSeq; XP_640504.5; XM_635412.3.
DR STRING; 44689.DDB0229338; -.
DR PaxDb; Q54T85; -.
DR GeneID; 8623319; -.
DR KEGG; ddi:DDB_G0281947; -.
DR dictyBase; DDB_G0281947; tra1.
DR eggNOG; KOG0889; Eukaryota.
DR HOGENOM; CLU_000129_1_0_1; -.
DR InParanoid; Q54T85; -.
DR OMA; NEWNQMQ; -.
DR PhylomeDB; Q54T85; -.
DR PRO; PR:Q54T85; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; ISS:dictyBase.
DR GO; GO:0005634; C:nucleus; ISS:dictyBase.
DR GO; GO:0000124; C:SAGA complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; ISS:dictyBase.
DR GO; GO:0004402; F:histone acetyltransferase activity; ISS:dictyBase.
DR GO; GO:0004672; F:protein kinase activity; ISS:dictyBase.
DR GO; GO:0003712; F:transcription coregulator activity; ISS:dictyBase.
DR GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR GO; GO:0016573; P:histone acetylation; ISS:dictyBase.
DR GO; GO:0006468; P:protein phosphorylation; ISS:dictyBase.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR033317; TRA1/TRRAP.
DR PANTHER; PTHR11139:SF1; PTHR11139:SF1; 5.
DR Pfam; PF02259; FAT; 1.
DR SUPFAM; SSF48371; SSF48371; 3.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW Coiled coil; Reference proteome.
FT CHAIN 1..4582
FT /note="Probable transcription-associated protein 1"
FT /id="PRO_0000376004"
FT DOMAIN 3185..3815
FT /note="FAT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00534"
FT DOMAIN 4171..4541
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT DOMAIN 4538..4582
FT /note="FATC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00534,
FT ECO:0000255|PROSITE-ProRule:PRU00535"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 219..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 794..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1152..1195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1483..1570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2341..2410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2537..2567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2637..2662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2741..2789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3491..3517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3821..3928
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4177..4183
FT /note="G-loop"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT REGION 4312..4337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4400..4408
FT /note="Catalytic loop"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT REGION 4429..4451
FT /note="Activation loop"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT COILED 2944..2991
FT /evidence="ECO:0000255"
FT COMPBIAS 1..16
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..570
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2341..2402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2537..2554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3491..3509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3821..3913
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4582 AA; 515215 MW; FD1EAC1BA288654B CRC64;
MSTNPPQPPP SSTIASNPPQ PIATPMSTTN PSQPTITSSS AASSSSSSSS GNPVNFESYA
RRCFELNNNN EQTQLLALVT EIRDNIELVH TVEYPTFLNF LFPVFYNILR QGAVQFNDGP
EQKIRNTILD ILNKLPNNEL LRPHILVLLQ LSMYLLEVDN EENALVCLRI IIELHKNYRN
ALESEIQPFL NIVLKLYTDL PSTIEKTFSS SSSASLSTTT TAISPTTTTT TTPATATTPA
TTTATGNTIT TPPPATPPST TATAISPTSS TTTTTTATTA AAATIATTTA TTTITPPLPP
YMIKSIESFK ILTECPIVVI LLFQLYNSYM SSNVPKFIPL IIETLSLQAP ANSTVTHHSQ
YVDFIAAQVK TLYLLAYVLK WHIEQIKQYS DRFPRSVIQL LQNCPAHSSA IRKELLVTLR
HILSSDFKSK FIVYLDLLLD EKIILGTSRT SYESLRSMAY GSLADFIHNM RNELNINQIS
KVVAIYSRHL HDQTNPVSIQ IMSVKLIISL MDVIQRKQDP PEYKSRSIIY KVIESFINKF
SSLKRSIPKL LADQQKEKEK ELKDPQSLKD KLDGLSSANT TTSSTGEIII LDPVKDTRTL
IKTMTSSLRN IFWSLSACPI NKPGTGITTG AGATTTTTTN TNNTIIPPVR IALPSIEESL
LFIKLFKSTV KCFPIYGGCN PSPQEEKEMI ENFTASFMML DQRTFQEVST FILPFLYQRS
LNNPSLLLIP QGFLSVTQMN PTGVQINRVF LEVLTPFLYE KIRNLQPTDK PDICMIKLIK
LIFNAIQPNN NSGVGGSGGS NSSGGGGGGG SNSSNNSTNS NTTTNIDSTC VQQVLSSMIL
ILLKLITESK QIDSIQYLLL LKTIFKSCTR PDQSKEITLL FPIILETLND LLLSSSHSTM
IPAVQQLLIE LSLSIPVQIA TLLPSLHLLV KPLMLALDSS SSELLSTTFR ILELIVDNAT
GDFLLFTFRD NKSEFLQILS KHLRPAPYFY GPHAIRILGK MAGKSRSFSV LSPILSIDST
SNSRSIPSSN KNNNNNNYYY NGSCSNSENY SKVFKLLLPC ETGDDKTKSI PLDKSIQSIK
NILLYQLDDS YLQSNAYSLL KYYISLYLSS QDFLINQQSL LNELLNNLKQ SNNNNNNNSS
TVNLNIIELD NENENENDNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNIKTFKT
KEEYLNEIKN FKDLVYCLFL SITNDHLKEK FDSLKFLNNF IYHFVLYLST FKFNYSIISM
KELDPKIFLE ALVDVMSMSS HNIINQSNIE DLQTISTSKF NKAHITSLLD MIFNCSNQIF
SENSNSKKNN ELMTSSTDVK DGEKVEMETE DSLKKDEMSA AATSEIKKET NVVVENEQDK
DTVLISPIFK YLVKLFIKCC YDKDFSVKGA GLIGIEYIIE NVKLSWIQPF QHLILKSLLF
VCEDLSYSGY QPTIDYASEI IINLIKLCVP NLNIVPDSME IDQSTTTAST TETAATTTTT
ETATPMVTES TAIVTEPTAT TPTATPTSTP TSTSTPTPTP IPTATTSSTT TAPTTTTTTT
TNLSSSSTIN QKPHCKLNQL KLKDRELLKL ILEILMERIT SWSGHTRSLA QRMLTMISVE
ITKIPMSQLI EDLKMTVQKL LPKTPLKSLS ISLQTGVIDG LTFCLSQKPS PLIEIGADTV
RVLQECLNVA GDESSPTQQS QIKSSSAKSI SATNNLRVCG VEMVATAMTC PDFLQFECLE
FKNRIIRMFF KVVTARNKEM AMAAKRGLAN SIQQQRLHRD LLQTCLRPVL SNITDPKSLS
VPFLQGLSRL LELLSNCFNA ALGEKLFEYL KKFEEAGKLS YLANKYRDSE EVKICASIID
IFHLLPPAAK LLDSTIILTI RLEQSLCKEV TSPYREPLIR FLAKYPQRTI EIFMGQLPQF
NLIFRLILKH QPLSKPIVEE LANTYSIWLE AHLKSPSADI RFHTLSMVSI IRKQLPNWLP
ENRKVLDILI EYWRPLSHMI QSASNPLDIS NQTLRETKII VKCFLQYCKA HSEETDLYFY
MLSVLTLRAS MDFNFLRDYY QHDLAPSSTI EQKKKIIQTF LIFFKDQTIP SDNKVQAIQN
LITPILTNYF HQTDRNSSSG GGIIEDSLFI QLTKQTLETE VKASYDDTLL IELLQLETLL
VKNLSSVLVD CRKELIKFAW NHLKNEDLTC KQSAYILACG FIEAYETPHK IVLQVYVPLL
RAYQPESKHL VKQALDILMP CFKTRLPGGD PKNSTWVKWT KKIIVEEGHT TAQLVHIIQL
IVRHPQLFYP SRSQFVPHII LLLPKIALGS NLTAENKKLS IDIADTIIIW EKMRMSNLQQ
SIKTSSSSLP TTTTTTTSSN KPTDSSSLPP NTPIAEGSIT TPSQGGVATP NVSDSTPTPG
IHHGATNIDD EYRPPLSAIE HISLFLIRMA SNWYHINEKC SELLRQTLVI WPETNIKFSV
FEKPMNTDQP QMISTCLSML NLIAEYQVNT FIPNNVVALQ QSLLQALNSD NAKISSLLGS
LFKKILAAFP LPTNNTTTTT PVSSTTTTEQ SSDSSSLPPP PPVQVTKPIP NEMVSFYTFI
GTQFEMILGA FDKNYNLSIL SNIKVFSDHS ESFIDPYISL IVKVLIRLTR NYLSQDSDGG
TGSLANKPLS SSGSTSQTGG ASQTATSASN VVLKKSNSEI ISGLCKTYGF LKTKTTKLNS
DQRNAFIQSL LVLIERSNDV ELLSEIIKVV DYLISISPSP SPSTTPVVTE TTIPSTTTTT
TTAATTTTTT TPSTTTTAAT TTTAPTTTET TTTAATTTIT PFLTIKEKIN FLIKLGRVDQ
LSNAELSLSY YKLVLSFYSE SNSSSKQELS QLEPCFMMGL RNTVDQGMRK SLFNILHKSI
GTTPYQRLNY IIGVQQWDIL GTTYWIKHAL DLLLAILPND KFVKISNFCS KLPTSLKFAN
RNGNDINQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQHHQQE QPMEIDENLV
VEQSSSVNKG NEEFKKSLKL HTQWLESLKN EESLKFSEFN ENLRELIFID SHLVNDLWCH
LFSDMWSDLT KEEQFKLSKS LTLLLSKDYT KKVPLVSKPI IPPTSIPISK PIITTTTSTS
SSTSTTTPIT TIPLINNSQL ITIVTLTQQQ TNPIIVPSLR EPNVIKTWME TLGMCKPIPK
VPIEVISFLG ENYNCWYYAI RMIEQQLIDR QKLLDSTDIN WDYLSYLYGA IGEKDLLYGI
YRKRYQCDET KLGLLLEQFY MFQSSQEVFL SAMNKYSAVG CKPTPRSENL LWEDHWLECA
KRLNQWNFVH EFSKEKNMYD LTIESAWKIP QWNSVKENMK KMMSQGDTSI RKILQGYFLT
NEKRYHEVDP AIVTSNQLIL DKWVSLPERS FRSHTNSLVE MQQVVELQES VHILKEISNI
TLSQQPADLS RSFLTSNYIK SIFNIWRERL PNKDEDLLIW FELMAWRQQV FNIIGTPSMN
GGIGANPVTP TNTTTTITNP DGTTTTTTTP LPPPQQPINQ IEFASPRYMV LEMAWTMNKY
SHIVRKHNII EVCLNSLSKM FDLQIELHDI FLNLKEQIKC YLQLPTHYDT GISIINSTNL
DFFTPMQKGE FLQLKGEFLN RLGRYDEANQ SFASSVSQYE NSAKNWISWA HFCDNQFTNH
SSSSITPSST PTTYDIKTQW AESAISCYIQ GIKCDPKYGS RYVPRIFWLL YLNGSGEVPQ
QIQTQQQQQQ AAAQGGLPPQ PRKLTPAQSV FQSFLNSWTI LPQWIWLNYM PQLISGAANL
LNFPGYGFLC WQMIGKICYL FPNSSYYHFR KLVLEMKSNA SKFTTSPPTT TTTATTTTTA
TTTITTATTT STPTQTTPTQ NTTTPIKEES STTTATTTPA VPSTSTPTST SAPAPISTST
NTPPNATTTT PQANTTSPPP PSSTFSPLKM TETLSLGLHQ YHSCLINEID MMLGSFSILS
GSIPAVYQFN GSLNQILLEA FKLNKIEDSI YNSIRSLYKH YFVNEIKYQN SKEFLEAYKS
EFKVDFIEFN LDDIVSDTIK KESDQETNVV EGTTNVSKEL ETTSEKQQQQ QQQLPTISIL
LLIEKLIKWI DRKPDNSLIT VVNTDQSTNY YGIDTMICLE SICPQLVNFK PSILEIPGQY
NTNRDPNIEN NVKVEKVGMF AKLIKHSNGM VCPRITLYGG NGKAYQFLIE SSPSLINGIT
NSNNNNVARV YERKNQLLGS INSMLIKNRE TRRRGLTLNS YPTVVPIKNS LTMIQNIGND
SIKQLAEVWY THSNQSNLFK PMLKYKEMLL NSNLHTELLS KKDQDGDLEF TNITEDNNIS
SSSSSSSSSG SNSGENSPII DSSKLVVFRE MSKEIGDELM INYIQSTLLP TNYQDQYEFK
LNFSNQFGLH SLLQYILFSD IGDIDPSKIY LTKSTGSVYY NDWSLKLTNR KLGFDLLQDN
PYNQQQLLRL SPNIRNYLGP LYLEGSYLSS MISTCICLSD LKDQLVNSIN LFIFDEYMCM
NNVEPLQQSE QNKDRNIHYE FIDKTTATVH QMLENRIDSL TPSSQPDKTC FISPIVKKVN
QLIQNSLSSN ISQLDQLSCP WL
