TRABD_HUMAN
ID TRABD_HUMAN Reviewed; 376 AA.
AC Q9H4I3; Q19CC5; Q96ED8; Q9H7N1; Q9UGX6; Q9UGX7;
DT 03-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=TraB domain-containing protein;
DE AltName: Full=Protein TTG2;
GN Name=TRABD; Synonyms=TTG2; ORFNames=PP2447;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Xiao L., Cheng J., Hong Y., Zhang L.;
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12529303; DOI=10.1101/gr.695703;
RA Collins J.E., Goward M.E., Cole C.G., Smink L.J., Huckle E.J., Knowles S.,
RA Bye J.M., Beare D.M., Dunham I.;
RT "Reevaluating human gene annotation: a second-generation analysis of
RT chromosome 22.";
RL Genome Res. 13:27-36(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 39-376.
RC TISSUE=Spleen;
RX PubMed=11214971; DOI=10.1093/dnares/7.6.357;
RA Hattori A., Okumura K., Nagase T., Kikuno R., Hirosawa M., Ohara O.;
RT "Characterization of long cDNA clones from human adult spleen.";
RL DNA Res. 7:357-366(2000).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [8]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-65, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [10]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9H4I3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H4I3-2; Sequence=VSP_002441;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB15737.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; DQ529300; ABF71986.1; -; Genomic_RNA.
DR EMBL; AL449244; CAC15001.1; -; mRNA.
DR EMBL; AL022328; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471138; EAW73500.1; -; Genomic_DNA.
DR EMBL; BC012445; AAH12445.1; -; mRNA.
DR EMBL; AK024447; BAB15737.1; ALT_FRAME; mRNA.
DR CCDS; CCDS14086.1; -. [Q9H4I3-1]
DR RefSeq; NP_001307413.1; NM_001320484.1.
DR RefSeq; NP_001307414.1; NM_001320485.1. [Q9H4I3-1]
DR RefSeq; NP_001307416.1; NM_001320487.1. [Q9H4I3-1]
DR RefSeq; NP_001307417.1; NM_001320488.1.
DR RefSeq; NP_079480.2; NM_025204.3. [Q9H4I3-1]
DR RefSeq; XP_016884433.1; XM_017028944.1. [Q9H4I3-1]
DR AlphaFoldDB; Q9H4I3; -.
DR BioGRID; 123218; 85.
DR IntAct; Q9H4I3; 26.
DR MINT; Q9H4I3; -.
DR STRING; 9606.ENSP00000305664; -.
DR iPTMnet; Q9H4I3; -.
DR PhosphoSitePlus; Q9H4I3; -.
DR BioMuta; TRABD; -.
DR DMDM; 20141036; -.
DR EPD; Q9H4I3; -.
DR jPOST; Q9H4I3; -.
DR MassIVE; Q9H4I3; -.
DR MaxQB; Q9H4I3; -.
DR PaxDb; Q9H4I3; -.
DR PeptideAtlas; Q9H4I3; -.
DR PRIDE; Q9H4I3; -.
DR ProteomicsDB; 80843; -. [Q9H4I3-1]
DR ProteomicsDB; 80844; -. [Q9H4I3-2]
DR Antibodypedia; 14181; 53 antibodies from 16 providers.
DR DNASU; 80305; -.
DR Ensembl; ENST00000303434.8; ENSP00000305664.4; ENSG00000170638.10. [Q9H4I3-1]
DR Ensembl; ENST00000380909.9; ENSP00000370295.4; ENSG00000170638.10. [Q9H4I3-1]
DR Ensembl; ENST00000395827.5; ENSP00000379171.1; ENSG00000170638.10. [Q9H4I3-1]
DR GeneID; 80305; -.
DR KEGG; hsa:80305; -.
DR MANE-Select; ENST00000380909.9; ENSP00000370295.4; NM_001320485.2; NP_001307414.1.
DR UCSC; uc003bjs.2; human. [Q9H4I3-1]
DR CTD; 80305; -.
DR DisGeNET; 80305; -.
DR GeneCards; TRABD; -.
DR HGNC; HGNC:28805; TRABD.
DR HPA; ENSG00000170638; Low tissue specificity.
DR neXtProt; NX_Q9H4I3; -.
DR OpenTargets; ENSG00000170638; -.
DR PharmGKB; PA145147893; -.
DR VEuPathDB; HostDB:ENSG00000170638; -.
DR eggNOG; KOG2860; Eukaryota.
DR GeneTree; ENSGT00390000009067; -.
DR HOGENOM; CLU_034593_0_1_1; -.
DR InParanoid; Q9H4I3; -.
DR OMA; WMGRRTV; -.
DR OrthoDB; 876990at2759; -.
DR PhylomeDB; Q9H4I3; -.
DR TreeFam; TF314184; -.
DR PathwayCommons; Q9H4I3; -.
DR SignaLink; Q9H4I3; -.
DR BioGRID-ORCS; 80305; 15 hits in 1070 CRISPR screens.
DR ChiTaRS; TRABD; human.
DR GenomeRNAi; 80305; -.
DR Pharos; Q9H4I3; Tdark.
DR PRO; PR:Q9H4I3; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q9H4I3; protein.
DR Bgee; ENSG00000170638; Expressed in granulocyte and 177 other tissues.
DR ExpressionAtlas; Q9H4I3; baseline and differential.
DR Genevisible; Q9H4I3; HS.
DR CDD; cd14726; TraB_PrgY-like; 1.
DR InterPro; IPR002816; TraB/PrgY/GumN_fam.
DR InterPro; IPR046345; TraB_PrgY-like.
DR PANTHER; PTHR21530; PTHR21530; 1.
DR Pfam; PF01963; TraB_PrgY_gumN; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..376
FT /note="TraB domain-containing protein"
FT /id="PRO_0000050825"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT MOD_RES 65
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 30..75
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_002441"
SQ SEQUENCE 376 AA; 42321 MW; A55D853EC0E9C5CA CRC64;
MDGEEQQPPH EANVEPVVPS EASEPVPRVL SGDPQNLSDV DAFNLLLEMK LKRRRQRPNL
PRTVTQLVAE DGSRVYVVGT AHFSDDSKRD VVKTIREVQP DVVVVELCQY RVSMLKMDES
TLLREAQELS LEKLQQAVRQ NGLMSGLMQM LLLKVSAHIT EQLGMAPGGE FREAFKEASK
VPFCKFHLGD RPIPVTFKRA IAALSFWQKV RLAWGLCFLS DPISKDDVER CKQKDLLEQM
MAEMIGEFPD LHRTIVSERD VYLTYMLRQA ARRLELPRAS DAEPRKCVPS VVVGVVGMGH
VPGIEKNWST DLNIQEIMTV PPPSVSGRVS RLAVKAAFFG LLGYSLYWMG RRTASLVLSL
PAAQYCLQRV TEARHK
