ID   TRAC_PENCR              Reviewed;         417 AA.
AC   A0A481WNP6;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   05-JUN-2019, sequence version 1.
DT   03-AUG-2022, entry version 12.
DE   RecName: Full=C6 finger transcription factor traC {ECO:0000303|PubMed:30811183};
DE   AltName: Full=Terrestric acid biosynthesis cluster protein C {ECO:0000303|PubMed:30811183};
GN   Name=traC {ECO:0000303|PubMed:30811183};
OS   Penicillium crustosum (Blue mold fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=36656;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=PRB-2;
RX   PubMed=30811183; DOI=10.1021/jacs.9b00110;
RA   Fan J., Liao G., Kindinger F., Ludwig-Radtke L., Yin W.B., Li S.M.;
RT   "Peniphenone and penilactone formation in Penicillium crustosum via 1,4-
RT   Michael additions of ortho-quinone methide from hydroxyclavatol to gamma-
RT   butyrolactones from Crustosic Acid.";
RL   J. Am. Chem. Soc. 141:4225-4229(2019).
CC   -!- FUNCTION: C6 finger transcription factor; part of the tra gene cluster
CC       that produces terrestric acid (PubMed:30811183). The clavatol
CC       biosynthesis cluster cla and the terrestric acid cluster tra are both
CC       involved in the production of peniphenones and penilactones
CC       (PubMed:30811183). {ECO:0000269|PubMed:30811183}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; MK360919; QBK15051.1; -; Genomic_DNA.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..417
FT                   /note="C6 finger transcription factor traC"
FT                   /id="PRO_0000455057"
FT   DNA_BIND        44..73
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          75..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          104..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        104..118
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   417 AA;  45717 MW;  B0CA051913EDA8BA CRC64;
     MNFSEQFTGR SEPGRKANRT SNNNTNSTTN VATVTTDDSN RPACDRCKGQ KLRCIWENGS
     NTCRRCTRAR AVCQQPRPRP FGRPRCSTKS KHHVAQNQAN TKIWVSSTTQ QPQENDAEMP
     MATSDDHDPT SFLSSTAVDL PRYLGLASFP TDPSLQIAIS PPHGVHGNSF NLETGLLGNF
     SDAQFKNPAT FYQPQGFINA ANPATPAPVP VPASAPVSAD GASLFEFDPD DISGDSEHSH
     CHWLKQLGDL NVAIYQHPLH PKPAGVSTPG VSTGFSAEQV SLSSLQIGRL LHMTSRLGRL
     TEEIDSADHV QPKNDGSAES DSFGGIKLAI NDRSTLFVVL SCYVRLEETF AQALATVVEI
     RRRGPLSDDT YQLMPRLTVD GWSLECCQTM QIDFVIYICE QTLVRIRRSI TSLHADM