TRAD1_BOVIN
ID TRAD1_BOVIN Reviewed; 580 AA.
AC Q58D05; Q08E03;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=TRAF-type zinc finger domain-containing protein 1;
GN Name=TRAFD1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=Hereford; TISSUE=Fetal skin;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative feedback regulator that controls excessive innate
CC immune responses. Regulates both Toll-like receptor 4 (TLR4) and
CC DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway
CC by direct interaction with TRAF6 and attenuation of NF-kappa-B
CC activation. May negatively regulate the RLH pathway downstream from
CC MAVS and upstream of NF-kappa-B and IRF3 (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with MAVS, TICAM1, TRAF1, TRAF2, TRAF3 and TRAF6.
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q58D05-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q58D05-2; Sequence=VSP_023293;
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DR EMBL; BT021792; AAX46639.1; -; mRNA.
DR EMBL; BC123486; AAI23487.1; -; mRNA.
DR RefSeq; NP_001014908.1; NM_001014908.1. [Q58D05-1]
DR AlphaFoldDB; Q58D05; -.
DR STRING; 9913.ENSBTAP00000011542; -.
DR PRIDE; Q58D05; -.
DR Ensembl; ENSBTAT00000011542; ENSBTAP00000011542; ENSBTAG00000008761. [Q58D05-2]
DR GeneID; 512642; -.
DR KEGG; bta:512642; -.
DR CTD; 10906; -.
DR VEuPathDB; HostDB:ENSBTAG00000008761; -.
DR GeneTree; ENSGT00530000063869; -.
DR InParanoid; Q58D05; -.
DR OMA; AHQSSEC; -.
DR OrthoDB; 1113262at2759; -.
DR Proteomes; UP000009136; Chromosome 17.
DR Bgee; ENSBTAG00000008761; Expressed in myometrium and 108 other tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045824; P:negative regulation of innate immune response; ISS:UniProtKB.
DR Gene3D; 3.30.40.10; -; 2.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
PE 2: Evidence at transcript level;
KW Acetylation; Alternative splicing; Metal-binding; Phosphoprotein;
KW Reference proteome; Zinc; Zinc-finger.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:O14545"
FT CHAIN 2..580
FT /note="TRAF-type zinc finger domain-containing protein 1"
FT /id="PRO_0000278456"
FT ZN_FING 27..103
FT /note="TRAF-type"
FT REGION 197..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..236
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 392..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..566
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:O14545"
FT MOD_RES 190
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O14545"
FT MOD_RES 326
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O14545"
FT MOD_RES 414
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O14545"
FT MOD_RES 429
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O14545"
FT MOD_RES 469
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O14545"
FT VAR_SEQ 563
FT /note="K -> KQ (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_023293"
FT CONFLICT 496
FT /note="H -> R (in Ref. 2; AAI23487)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 580 AA; 64847 MW; DEC030958070A9D6 CRC64;
MAEFLNDQDT RLCDNCKKEI PVFNFTIHEI HCQRNIGVCP VCKEPFPKCD METHMATEHC
QVTCKCNKKL EKRQLKKHEE TECPLRLALC QHCDLELSVL KLKDHEDYCG ARTELCGTCG
RNVLVKDLKT HPEVCGRDVE EKRVEAAMPP NAYDESWGPD RIWIASQLRQ IEALDPPMRL
PRRPLRAFES DLFQSRTTNQ RSMTAQFPIQ NNLLEEQERQ ERNRSRQTPK ERGEDSANLD
FMLALSLQNE GQAPTLAEQD FWRVIYEADQ SREGPSALND IRGAVDETML PCEFCEELYP
EELLIDHQTS CNPSCALPPL SVGSTSPRGV EDPDAIFQKL MRESAGGQFE SLMGFSSSAP
VEDSVVIPCE FCGVQLEEEV LFHHQDQCDQ RPATANNHVS EGIPSQDLQP RETSPELPKR
RVRHQGDLSS GYMNDLKQEM AKGPTYPLPS SRPPNNTTAP PNRLSTSTSG PRPGCQPSPP
RALKLNNLDS QGVRGHSRNS HNGALAPGHV PAAYPARSLY PENLVPSFPR GPSGRYGASS
RSEGGRNPRV TPTAASYRSR TAKAKTPKQQ GAGDAEEEEE
